Optimal timing of contrast‑enhanced computed tomography in an evaluation of severe acute pancreatitis‑associated complications

Huang,Huali; Chen,Wenjing; Tang,Guodu; Liang,Zhihai; Qin,Mengbin; Qin,Minzhen; Tang,Yongfeng; Qin,Heping; Chang,Renjie

doi:10.3892/etm.2019.7700

Optimal timing of contrast‑enhanced computed tomography in an evaluation of severe acute pancreatitis‑associated complications

Authors:
- Huali Huang
- Wenjing Chen
- Guodu Tang
- Zhihai Liang
- Mengbin Qin
- Minzhen Qin
- Yongfeng Tang
- Heping Qin
- Renjie Chang
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Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Gastroenterology of The First People's Hospital of Nanning City, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530022, P.R. China, Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530007, P.R. China
Published online on: June 21, 2019 https://doi.org/10.3892/etm.2019.7700
Pages: 1029-1038
Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Dynamic contrast‑enhanced computed tomography (CECT) has been used previously to evaluate severe acute pancreatitis (SAP)‑associated complications. However, optimal time points of CECT have not yet been established. The present study aimed to determine optimal timings for CECT to be undertaken for patients with SAP. The results of CECT from 309 patients with SAP, who were classified into either infected or non‑infected SAP groups, were retrospectively analyzed. The severity and alterations in the periods within 72 h to >4 weeks of SAP onset were also assessed. In the analysis of the disease severity and changes, acute peripancreatic ﬂuid collection was detected, where the number of areas increased within 1 week of SAP onset but decreased within 4 weeks and longer. However, no significant differences were observed between the infected and non‑infected groups. The acute necrotic collection (ANC) areas were ≤30% of the area of the pancreas, with significantly more ANC areas and pancreatic necrosis in the infected SAP group compared with the non‑infected SAP group at a time interval of >4 weeks. The exudation of pleural effusion (PE) was elevated within 1 week, but decreased within 2 weeks and longer. The difference in the alteration of the exudation of PE was not statistically different between the two groups. In conclusion, the results suggest that the period between 72 h and 1 week of SAP onset is optimal timing of CECT to assess SAP‑associated complications, particularly for infected SAP patients.

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