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Article

Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells

  • Authors:
    • Jae Young Shin
    • Denis Nchang Che
    • Byoung Ok Cho
    • Hyun Ju Kang
    • Jisu Kim
    • Seon Il Jang
  • View Affiliations / Copyright

    Affiliations: Department of Health Management, Jeonju University, Jeonju, Jeollabuk 55069, Republic of Korea, Research Institute, ATO Q&A Co., Ltd., Jeonju, Jeollabuk 54840, Republic of Korea
  • Pages: 1914-1920
    |
    Published online on: July 1, 2019
       https://doi.org/10.3892/etm.2019.7721
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Abstract

Commiphora myrrha (Myrrh) is widely recognized for its anti‑inflammatory and antimicrobial properties, which are utilized for the treatment of oral ulcers, gingivitis, sinusitis, glomerulonephritis, brucellosis and a variety of skin disorders. The current study aimed to assess whether myrrh modulates itch‑associated interleukin (IL)‑31 cytokine production and histamine release in stimulated human mast cells (HMC‑1). To realize this, molecular biology techniques including real‑time quantitiative PCR, western blotting and ELISA were employed. The results indicated that Myrrh successfully suppressed phorbol myristate acetate and calcium ionophore‑stimulated mRNA expression, and reduced the production of IL‑31 in HMC‑1 cells. In addition, myrrh served as a suppressor of extracellular signal‑regulated kinase and NF‑κB activation, indicating its mechanism in the prevention of HMC‑1 cell IL‑31 production. Myrrh also prevented the release of histamine in HMC‑1 cells. Whilst the present study awaits in vivo support, the pharmacological actions of myrrh provide new indications as to its potential applicability for itch treatment, which cannot be treated with histamine receptor blockers alone.
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1 

Yosipovitch G and Papoiu AD: What causes itch in atopic dermatitis? Curr Allergy Asthma Rep. 8:306–311. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Sanders KM, Nattkemper LA and Yosipovitch G: Advances in understanding itching and scratching: A new era of targeted treatments. F1000Res. 5:F1000 Faculty Rev-2042. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Mollanazar NK, Smith PK and Yosipovitch G: Mediators of chronic pruritus in atopic dermatitis: Getting the itch out? Clin Rev Allergy Immunol. 51:263–292. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Tani E, Shiosaka S, Sato M, Ishikawa T and Tohyama M: Histamine acts directly on calcitonin gene-related peptide- and substance P-containing trigeminal ganglion neurons as assessed by calcium influx and immunocytochemistry. Neurosci Lett. 115:171–176. 1990. View Article : Google Scholar : PubMed/NCBI

5 

Dunford PJ, Williams KN, Desai PJ, Karlsson L, McQueen D and Thurmond RL: Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. J Allergy Clin Immunol. 119:176–183. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Simons FE, Simons KJ, Becker AB and Haydey RP: Pharmacokinetics and antipruritic effects of hydroxyzine in children with atopic dermatitis. J Pediatr. 104:123–127. 1984. View Article : Google Scholar : PubMed/NCBI

7 

Stempelj M and Ferjan I: Signaling pathway in nerve growth factor induced histamine release from rat mast cells. Inflamm Res. 54:344–349. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Metcalfe DD, Peavy RD and Gilfillan AM: Mechanisms of mast cell signaling in anaphylaxis. J Allergy Clin Immunol. 124:639–646; quiz 647–648. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Nemeth K, Wilson T, Rada B, Parmelee A, Mayer B, Buzas E, Falus A, Key S, Masszi T, Karpati S and Mezey E: Characterization and function of histamine receptors in human bone marrow stromal cells. Stem Cells. 30:222–231. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Nordlind K, Chin LB, Ahmed AA, Brakenhoff J, Theodorsson E and Liden S: Immunohistochemical localization of interleukin-6-like immunoreactivity to peripheral nerve-like structures in normal and inflamed human skin. Arch Dermatol Res. 288:431–435. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Stevens SR, Hanifin JM, Hamilton T, Tofte SJ and Cooper KD: Long-term effectiveness and safety of recombinant human interferon gamma therapy for atopic dermatitis despite unchanged serum IgE levels. Arch Dermatol. 134:799–804. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Q, Putheti P, Zhou Q, Liu Q and Gao W: Structures and biological functions of IL-31 and IL-31 receptors. Cytokine Growth Factor Rev. 19:347–356. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Takaoka A, Arai I, Sugimoto M, Yamaguchi A, Tanaka M and Nakaike S: Expression of IL-31 gene transcripts in NC/Nga mice with atopic dermatitis. Eur J Pharmacol. 516:180–181. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Weidinger S, Beck LA, Bieber T, Kabashima K and Irvine AD: Atopic dermatitis. Nat Rev Dis Primers. 4:12018. View Article : Google Scholar : PubMed/NCBI

15 

Lee CH: Progress of pruritus research in atopic dermatitis. Biomol Ther. 18:246–256. 2010. View Article : Google Scholar

16 

Rukwied R, Lischetzki G, McGlone F, Heyer G and Schmelz M: Mast cell mediators other than histamine induce pruritus in atopic dermatitis patients: A dermal microdialysis study. Br J Dermatol. 142:1114–1120. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Başer KHC, Demirci B, Dekebo A and Dagne E: Essential oils of some Boswellia spp., Myrrh and Opopanax. Flavour Fragr J. 18:153–156. 2003. View Article : Google Scholar

18 

Ljaljević Grbić M, Unković N, Dimkić I, Janaćković P, Gavrilović M, Stanojević O, Stupar M, Vujisić L, Jelikić A, Stanković S and Vukojević J: Frankincense and myrrh essential oils and burn incense fume against micro-inhabitants of sacral ambients. Wisdom of the ancients? J Ethnopharmacol. 219:1–14. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Mohamed AA, Ali SI, El-Baz FK, Hegazy AK and Kord MA: Chemical composition of essential oil and in vitro antioxidant and antimicrobial activities of crude extracts of Commiphora myrrha resin. Industr Crops Prod. 57:10–16. 2014. View Article : Google Scholar

20 

Albrecht U, Muller V, Schneider B and Stange R: Efficacy and safety of a herbal medicinal product containing myrrh, chamomile and coffee charcoal for the treatment of gastrointestinal disorders: A non-interventional study. BMJ Open Gastroenterol. 1:e0000152015. View Article : Google Scholar : PubMed/NCBI

21 

Langhorst J, Varnhagen I, Schneider SB, Albrecht U, Rueffer A, Stange R, Michalsen A and Dobos GJ: Randomised clinical trial: A herbal preparation of myrrh, chamomile and coffee charcoal compared with mesalazine in maintaining remission in ulcerative colitis-a double-blind, double-dummy study. Aliment Pharmacol Ther. 38:490–500. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Shameem I: Phytochemical & therapeutic potentials of Murr Makki (Commiphora myrrha): A review. Indian J Appl Res. 8:102–104. 2018.

23 

Hanus LO, Rezanka T, Dembitsky VM and Moussaieff A: Myrrh-Commiphora chemistry. Biomed Papers Med Faculty Univ Palacky, Olomouc, Czechoslovakia. 149:3–27. 2005. View Article : Google Scholar

24 

Baek SJ and Kim DH: The Study on anti-obesity of Myrrh ethanol extract. Korea J Herbol. 31:11–18. 2016. View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Jamshidi-Kia F, Lorigooini Z and Amini-Khoei H: Medicinal plants: Past history and future perspective. J Herbmed Pharmacol. 7:1–7. 2018. View Article : Google Scholar

27 

Panche AN, Diwan AD and Chandra SR: Flavonoids: An overview. J Nutr Sci. 5:e472016. View Article : Google Scholar : PubMed/NCBI

28 

Kim MS, Bae GS, Park KC, Koo BS, Kim BJ, Lee HJ, Seo SW, Shin YK, Jung WS, Cho JH, et al: Myrrh inhibits LPS-induced inflammatory response and protects from cecal ligation and puncture-induced sepsis. Evid Based Complement Alternat Med. 2012:2787182012.PubMed/NCBI

29 

Tipton DA, Lyle B, Babich H and Dabbous MKh: In vitro cytotoxic and anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells. Toxicol In Vitro. 17:301–310. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Fatani AJ, Alrojayee FS, Parmar MY, Abuohashish HM, Ahmed MM and Al-Rejaie SS: Myrrh attenuates oxidative and inflammatory processes in acetic acid-induced ulcerative colitis. Exp Ther Med. 12:730–738. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Kawakami Y, Hartman SE, Holland PM, Cooper JA and Kawakami T: Multiple signaling pathways for the activation of JNK in mast cells: Involvement of Bruton's tyrosine kinase, protein kinase C and JNK kinases, SEK1 and MKK7. J Immunol. 161:1795–1802. 1998.PubMed/NCBI

32 

Park HJ, Lee HJ, Choi MS, Son DJ, Song HS, Song MJ, Lee JM, Han SB, Kim Y and Hong JT: JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin. J Inflamm (Lond). 5:72008. View Article : Google Scholar : PubMed/NCBI

33 

Craig R, Larkin A, Mingo AM, Thuerauf DJ, Andrews C, McDonough PM and Glembotski CC: p38 MAPK and NF-kappa B collaborate to induce interleukin-6 gene expression and release. Evidence for a cytoprotective autocrine signaling pathway in a cardiac myocyte model system. J Biol Chem. 275:23814–23824. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Che DN, Cho BO, Shin JY, Kang HJ, Kim YS and Jang SI: Fisetin inhibits IL-31 production in stimulated human mast cells: Possibilities of fisetin being exploited to treat histamine-independent pruritus. Life Sci. 201:121–129. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Maier E, Werner D, Duschl A, Bohle B and Horejs-Hoeck J: Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way. J Immunol. 193:645–654. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Wang Y, Zhou B, Lu J, Chen Q, Ti H, Huang W, Li J, Yang Z, Jiang Z and Wang X: Inhibition of influenza virus via a sesquiterpene fraction isolated from Laggera pterodonta by targeting the NF-κB and p38 pathways. BMC Complement Altern Med. 17:252017. View Article : Google Scholar : PubMed/NCBI

37 

Salminen A, Lehtonen M, Suuronen T, Kaarniranta K and Huuskonen J: Terpenoids: Natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential. Cell Mol Life Sci. 65:2979–2999. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Deepak V, Kasonga A, Kruger MC and Coetzee M: Inhibitory effects of eugenol on RANKL-induced osteoclast formation via attenuation of NF-κB and MAPK pathways. Connect Tissue Res. 56:195–203. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Karunaweera N, Raju R, Gyengesi E and Münch G: Plant polyphenols as inhibitors of NF-κB induced cytokine production-a potential anti-inflammatory treatment for Alzheimer's disease? Front Mol Neurosci. 8:242015. View Article : Google Scholar : PubMed/NCBI

40 

Je IG, Kim HH, Park PH, Kwon TK, Seo SY, Shin TY and Kim SH: SG-HQ2 inhibits mast cell-mediated allergic inflammation through suppression of histamine release and pro-inflammatory cytokines. Exp Biol Med (Maywood). 240:631–638. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Nomicos EY: Myrrh: Medical marvel or myth of the Magi? Holist Nurs Pract. 21:308–323. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shin JY, Che DN, Cho BO, Kang HJ, Kim J and Jang SI: Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells. Exp Ther Med 18: 1914-1920, 2019.
APA
Shin, J.Y., Che, D.N., Cho, B.O., Kang, H.J., Kim, J., & Jang, S.I. (2019). Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells. Experimental and Therapeutic Medicine, 18, 1914-1920. https://doi.org/10.3892/etm.2019.7721
MLA
Shin, J. Y., Che, D. N., Cho, B. O., Kang, H. J., Kim, J., Jang, S. I."Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells". Experimental and Therapeutic Medicine 18.3 (2019): 1914-1920.
Chicago
Shin, J. Y., Che, D. N., Cho, B. O., Kang, H. J., Kim, J., Jang, S. I."Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells". Experimental and Therapeutic Medicine 18, no. 3 (2019): 1914-1920. https://doi.org/10.3892/etm.2019.7721
Copy and paste a formatted citation
x
Spandidos Publications style
Shin JY, Che DN, Cho BO, Kang HJ, Kim J and Jang SI: Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells. Exp Ther Med 18: 1914-1920, 2019.
APA
Shin, J.Y., Che, D.N., Cho, B.O., Kang, H.J., Kim, J., & Jang, S.I. (2019). Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells. Experimental and Therapeutic Medicine, 18, 1914-1920. https://doi.org/10.3892/etm.2019.7721
MLA
Shin, J. Y., Che, D. N., Cho, B. O., Kang, H. J., Kim, J., Jang, S. I."Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells". Experimental and Therapeutic Medicine 18.3 (2019): 1914-1920.
Chicago
Shin, J. Y., Che, D. N., Cho, B. O., Kang, H. J., Kim, J., Jang, S. I."Commiphora myrrha inhibits itch‑associated histamine and IL‑31 production in stimulated mast cells". Experimental and Therapeutic Medicine 18, no. 3 (2019): 1914-1920. https://doi.org/10.3892/etm.2019.7721
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