A novel quantitative method for estimating bone mineral density using B‑mode ultrasound and radiofrequency signals‑a pilot study on patients with rheumatoid arthritis

Bojincă,Violeta‑Claudia; Popescu,Claudiu  C.; Decianu,Raluca‑Daniela; Dobrescu,Andrei; Bălănescu,Șerban  Mihai; Bălănescu,Andra‑Rodica; Bojincă,Mihai

doi:10.3892/etm.2019.7746

A novel quantitative method for estimating bone mineral density using B‑mode ultrasound and radiofrequency signals‑a pilot study on patients with rheumatoid arthritis

Authors:
- Violeta‑Claudia Bojincă
- Claudiu C. Popescu
- Raluca‑Daniela Decianu
- Andrei Dobrescu
- Șerban Mihai Bălănescu
- Andra‑Rodica Bălănescu
- Mihai Bojincă
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Affiliations: Internal Medicine and Rheumatology Department, Sfânta Maria Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest 011172, Romania, Ion Stoia Clinical Centre for Rheumatic Diseases, Carol Davila University of Medicine and Pharmacy, Bucharest 031167, Romania, Cardiology Department, Elias University Emergency Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest 011461, Romania, Rheumatology Department, Dr I. Cantacuzino Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest 030167, Romania
Published online on: July 8, 2019 https://doi.org/10.3892/etm.2019.7746
Pages: 1661-1668
Copyright: © Bojincă et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The objective of the present study was to evaluate whether an innovative quantitative ultrasound (QUS) technique, Radiofrequency Echographic Multi Spectromety, which combines B‑mode ultrasound and radiofrequency signals, is reliable in typical Romanian patients compared to previous results obtained using dual‑energy X‑ray absorptiometry (DXA). The study prospectively included previously unscreened post‑menopausal females with rheumatoid arthritis (RA) and age‑matched healthy controls. Bone mineral density (BMD) measurements were performed with an EchoS machine (Echolight®), which combines B‑mode ultrasound and radiofrequency signals. The study included 106 RA patients, with a median disease duration of 3.2 (0.5‑22) years and 119 controls. RA patients had a significantly lower body weight, body mass index (BMI) and basal metabolic rate (BMR) than the controls, while the prevalence of obesity and body fat differed insignificantly. RA patients had a significantly lower spine and hip BMD, higher fracture risk and higher prevalence of osteoporosis. Compared to RA patients without osteoporosis, those with osteoporosis were significantly older and had a longer menopause duration, but they had a significantly lower BMI, body fat, BMR and prevalence of obesity. Among the controls and RA patients, the median spine and hip BMD became significantly higher as the BMI increased from underweight to obesity. In conclusion, osteoporosis is prevalent among RA patients, as a part of a complex transformation of body mass composition, involving BMI and fat mass. The novel QUS scanning technique was able to replicate the results of the established DXA measurement of BMD and is potentially suitable for screening wide populations for osteoporosis.

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