Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits

Chen,Kefei; Dai,Feihu; Li,Guangxu; Dong,Jirong; Wang,Yuhai

doi:10.3892/etm.2019.7785

Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits

Authors:
- Kefei Chen
- Feihu Dai
- Guangxu Li
- Jirong Dong
- Yuhai Wang
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Affiliations: Department of Neurosurgery, Wuxi Clinical College of Anhui Medical University, Craniocerebral Injury Cure Center of People's Liberation Army, The 101st Hospital of People's Liberation Army, Wuxi, Jiangsu 214044, P.R. China
Published online on: July 17, 2019 https://doi.org/10.3892/etm.2019.7785
Pages: 2104-2110
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to investigate the use of computerized tomography (CT) perfusion for evaluating cerebral hemodynamics following traumatic brain injury (TBI) in rabbits. The animals were randomly assigned into four groups (n=10 animals/group): i) Control, ii) TBI, iii) TBI + common decompression and iv) TBI + controlled decompression groups. A TBI model was established in rabbits using epidural balloon inflation. In the groups receiving intervention, animals were provided common decompression or controlled decompression treatments. Conventional CT and CT perfusion scanning were performed, with cerebral hemodynamic indices, including regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and mean transit time (MTT) being measured. Blood‑brain barrier (BBB) permeability was evaluated using Evans blue staining. Compared with those in the control group, rCBF and rCBV values of the bilateral temporal lobes and basal ganglion in the TBI, TBI + common decompression and TBI + controlled decompression groups were significantly lower, whereas the MTT values were markedly prolonged and Evans blue dye content was greatly increased (P<0.01). Controlled decompression was demonstrated to be more potent than common decompression for preventing TBI‑induced decline in rCBF and rCBV values in the bilateral temporal lobes and basal ganglion, as well as reversing TBI‑induced extension of MTT in the bilateral temporal lobes (P<0.01 vs. TBI group). However, neither common nor controlled decompression could reduce TBI‑induced increase in BBB permeability. In conclusion, these findings indicate that CT perfusion may be used to monitor cerebral hemodynamics following TBI in rabbits. Controlled decompression was deduced to be more potent than common decompression for preventing abnormalities in cerebral hemodynamics after TBI.

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