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Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits

  • Authors:
    • Kefei Chen
    • Feihu Dai
    • Guangxu Li
    • Jirong Dong
    • Yuhai Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Wuxi Clinical College of Anhui Medical University, Craniocerebral Injury Cure Center of People's Liberation Army, The 101st Hospital of People's Liberation Army, Wuxi, Jiangsu 214044, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2104-2110
    |
    Published online on: July 17, 2019
       https://doi.org/10.3892/etm.2019.7785
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Abstract

The present study aimed to investigate the use of computerized tomography (CT) perfusion for evaluating cerebral hemodynamics following traumatic brain injury (TBI) in rabbits. The animals were randomly assigned into four groups (n=10 animals/group): i) Control, ii) TBI, iii) TBI + common decompression and iv) TBI + controlled decompression groups. A TBI model was established in rabbits using epidural balloon inflation. In the groups receiving intervention, animals were provided common decompression or controlled decompression treatments. Conventional CT and CT perfusion scanning were performed, with cerebral hemodynamic indices, including regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and mean transit time (MTT) being measured. Blood‑brain barrier (BBB) permeability was evaluated using Evans blue staining. Compared with those in the control group, rCBF and rCBV values of the bilateral temporal lobes and basal ganglion in the TBI, TBI + common decompression and TBI + controlled decompression groups were significantly lower, whereas the MTT values were markedly prolonged and Evans blue dye content was greatly increased (P<0.01). Controlled decompression was demonstrated to be more potent than common decompression for preventing TBI‑induced decline in rCBF and rCBV values in the bilateral temporal lobes and basal ganglion, as well as reversing TBI‑induced extension of MTT in the bilateral temporal lobes (P<0.01 vs. TBI group). However, neither common nor controlled decompression could reduce TBI‑induced increase in BBB permeability. In conclusion, these findings indicate that CT perfusion may be used to monitor cerebral hemodynamics following TBI in rabbits. Controlled decompression was deduced to be more potent than common decompression for preventing abnormalities in cerebral hemodynamics after TBI.
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Copy and paste a formatted citation
Spandidos Publications style
Chen K, Dai F, Li G, Dong J and Wang Y: Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits. Exp Ther Med 18: 2104-2110, 2019.
APA
Chen, K., Dai, F., Li, G., Dong, J., & Wang, Y. (2019). Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits. Experimental and Therapeutic Medicine, 18, 2104-2110. https://doi.org/10.3892/etm.2019.7785
MLA
Chen, K., Dai, F., Li, G., Dong, J., Wang, Y."Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits". Experimental and Therapeutic Medicine 18.3 (2019): 2104-2110.
Chicago
Chen, K., Dai, F., Li, G., Dong, J., Wang, Y."Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits". Experimental and Therapeutic Medicine 18, no. 3 (2019): 2104-2110. https://doi.org/10.3892/etm.2019.7785
Copy and paste a formatted citation
x
Spandidos Publications style
Chen K, Dai F, Li G, Dong J and Wang Y: Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits. Exp Ther Med 18: 2104-2110, 2019.
APA
Chen, K., Dai, F., Li, G., Dong, J., & Wang, Y. (2019). Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits. Experimental and Therapeutic Medicine, 18, 2104-2110. https://doi.org/10.3892/etm.2019.7785
MLA
Chen, K., Dai, F., Li, G., Dong, J., Wang, Y."Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits". Experimental and Therapeutic Medicine 18.3 (2019): 2104-2110.
Chicago
Chen, K., Dai, F., Li, G., Dong, J., Wang, Y."Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits". Experimental and Therapeutic Medicine 18, no. 3 (2019): 2104-2110. https://doi.org/10.3892/etm.2019.7785
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