Open Access

Pemphigus vulgaris - approach and management (Review)

  • Authors:
    • Ioana Adriana Popescu
    • Laura Statescu
    • Dan Vata
    • Elena Porumb-Andrese
    • Adriana Ionela Patrascu
    • Ioana-Alina Grajdeanu
    • Laura Gheuca Solovastru
  • View Affiliations

  • Published online on: August 30, 2019     https://doi.org/10.3892/etm.2019.7964
  • Pages: 5056-5060
  • Copyright: © Popescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The place of pemphigus vulgaris (PV) among autoimmune bullous dermatoses is well known. In pemphigus, IgG autoantibodies are directed against desmogleins 1 and 3, which are part of the cadherin family of cell-cell adhesion molecules. These structures are responsible for maintaining the intercellular adherence in stratified squamous epithelia, such as the skin and oral mucosa. The incidence of autoimmune bullous dermatoses is steadily increasing, being associated with a high degree of morbidity. The pathophysiology of these dermatoses is very well understood, complemented by recent genetic studies. The gold standard for the diagnosis of pemphigus vulgaris is the detection of autoantibodies or complement component 3 by direct immunofluorescence microscopy of a perilesional biopsy. Early diagnosis and initiation of treatment are necessary in order to achieve a favorable prognosis. Although the first line of treatment is corticotherapy, there are no clear guidelines on dosing regimens, and long-term adverse effects are important. Corticosteroid-sparing adjuvant therapies have been employed in the treatment of PV, aiming to reduce the necessary cumulative dose of corticosteroids. In addition, therapies with anti-CD20 antibodies are used, but antigen-specific immune suppression-based treatments represent the future.

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December 2019
Volume 18 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Popescu, I.A., Statescu, L., Vata, D., Porumb-Andrese, E., Patrascu, A.I., Grajdeanu, I., & Solovastru, L.G. (2019). Pemphigus vulgaris - approach and management (Review). Experimental and Therapeutic Medicine, 18, 5056-5060. https://doi.org/10.3892/etm.2019.7964
MLA
Popescu, I. A., Statescu, L., Vata, D., Porumb-Andrese, E., Patrascu, A. I., Grajdeanu, I., Solovastru, L. G."Pemphigus vulgaris - approach and management (Review)". Experimental and Therapeutic Medicine 18.6 (2019): 5056-5060.
Chicago
Popescu, I. A., Statescu, L., Vata, D., Porumb-Andrese, E., Patrascu, A. I., Grajdeanu, I., Solovastru, L. G."Pemphigus vulgaris - approach and management (Review)". Experimental and Therapeutic Medicine 18, no. 6 (2019): 5056-5060. https://doi.org/10.3892/etm.2019.7964