Venous thromboembolism in cancer patients: Still looking for answers (Review)

  • Authors:
    • Roua Anamaria Iorga
    • Ovidiu Gabriel Bratu
    • Radu Dragos Marcu
    • Traian Constantin
    • Dan Liviu Dorel Mischianu
    • Bogdan Socea
    • Mihnea‑Alexandru Gaman
    • Camelia Cristina Diaconu
  • View Affiliations

  • Published online on: September 18, 2019     https://doi.org/10.3892/etm.2019.8019
  • Pages: 5026-5032
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Patients with cancer‑associated venous thromboembolism (VTE) represent a real challenge in clinical practice. Patients with cancer have a greater risk both of VTE and bleeding. There are only a few studies regarding the therapeutic approach of VTE in patients with cancer, especially after cancer surgery, and on thromboprophylaxis during chemotherapy. Many of the anticoagulation therapy recommendations for cancer patients are extrapolated from trials that are not conducted in cancer cohorts. It is essential to assess the efficacy and safety of VTE prophylaxis in this particular subgroup, which bears higher risks both of VTE recurrence and major hemorrhagic events. The introduction of direct oral anticoagulants in everyday practice represented a major evolution of the anticoagulant treatment. Direct anticoagulants could represent a more appealing alternative to low‑molecular‑weight heparin in paraneoplastic venous thrombosis, due to the patient comfort, easy administration of the drug and emerging studies that prove similar efficacy and safety as the standard treatment. However, there is limited data on the treatment with direct oral anticoagulants in patients with paraneoplastic venous thromboembolism.

Related Articles

Journal Cover

December 2019
Volume 18 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Iorga, R.A., Bratu, O.G., Marcu, R.D., Constantin, T., Mischianu, D.L., Socea, B. ... Diaconu, C.C. (2019). Venous thromboembolism in cancer patients: Still looking for answers (Review). Experimental and Therapeutic Medicine, 18, 5026-5032. https://doi.org/10.3892/etm.2019.8019
MLA
Iorga, R. A., Bratu, O. G., Marcu, R. D., Constantin, T., Mischianu, D. L., Socea, B., Gaman, M., Diaconu, C. C."Venous thromboembolism in cancer patients: Still looking for answers (Review)". Experimental and Therapeutic Medicine 18.6 (2019): 5026-5032.
Chicago
Iorga, R. A., Bratu, O. G., Marcu, R. D., Constantin, T., Mischianu, D. L., Socea, B., Gaman, M., Diaconu, C. C."Venous thromboembolism in cancer patients: Still looking for answers (Review)". Experimental and Therapeutic Medicine 18, no. 6 (2019): 5026-5032. https://doi.org/10.3892/etm.2019.8019