Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy

  • Authors:
    • Luyifei Li
    • Ling Jing
    • Jiyi Zhao
    • Jiachen Lv
    • Wen Yang
    • Weimin Li
    • Lijun Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Internal Critical Illness, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China, Department of The Fourth Cardiovascular, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China, Department of Colorectal Surgery, The Tumor Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China, Department of The First Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China, Department of The Fifth Cardiovascular, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4313-4321
    |
    Published online on: October 7, 2019
       https://doi.org/10.3892/etm.2019.8079
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate variations in the Ras homolog gene family, member A (RhoA)‑Rho‑associated protein kinase 2 (ROCK2)‑myosin light chain (MYL) pathway in a rat model of alcoholic cardiomyopathy (ACM) and the role of angiotensin‑converting enzyme inhibitor drugs. Rat models of ACM were established via alcoholic gavage + free access to alcohol. The structural and functional changes of the heart were analyzed by hematoxylin‑eosin staining, Masson's trichrome staining, immunohistochemistry staining, western blotting and fluorescence quantitative polymerase chain reaction. A total of 16 weeks later, a decreased ejection fraction and left ventricular fractional shortening in the alcohol group compared with the control group were demonstrated resulting in an increased left ventricular end diastolic diameter. These adverse effects were ameliorated following treatment with valsartan. In addition, the alcohol group revealed a disorganized arrangement of myocardial filaments, which was improved upon treatment with valsartan. RhoA and ROCK2 protein expression significantly increased in myocardial cells in the alcohol compared with the control group. Following drug intervention with valsartan, expression of RhoA and ROCK2 proteins were inhibited in the alcohol group. Furthermore, significantly elevated RhoA and ROCK2 and decreased MYL protein and mRNA expression in the alcohol group was demonstrated compared with the control group. Administration of valsartan reversed the expression profile of RhoA, ROCK and MYL in ACM. Expression of RhoA and ROCK were elevated with downregulation of MYL resulting in heart failure. However, the angiotensin receptor antagonist diminished the expression of RhoA and ROCK and enhanced the expression of MYL. The results of the present study suggest a curative effect of valsartan in ACM.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Piano MR: Alcoholic cardiomyopathy: Incidence, clinical characteristics, and pathophysiology. Chest. 121:1638–1650. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Skotzko CE, Vrinceanu A, Krueger L and Freudenberger R: Alcohol use and congestive heart failure: Incidence, importance, and approaches to improved history taking. Heart Fail Rev. 14:51–55. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Berger J and Moller DE: The mechanisms of action of PPARs. Annu Rev Med. 53:409–435. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW and Kelly DP: A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content. Proc Natl Acad Sci USA. 100:1226–1231. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Barger PM, Brandt JM, Leone TC, Weinheimer CJ and Kelly DP: Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. J Clin Invest. 105:1723–1730. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Berger J and Moller DE: The mechanisms of action of PPARs. Annu Rev Med. 53:409–435. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Mishra PK, Tyagi N, Kundu S and Tyagi SC: MicroRNAs are involved in homocysteine-induced cardiac remodeling. Cell Biochem Biophys. 55:153–162. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Hultberg B, Berglund M, Andersson A and Frank A: Elevated plasma homocysteine in alcoholics. Alcohol Clin Exp Res. 17:687–689. 1993. View Article : Google Scholar : PubMed/NCBI

9 

Stickel F, Choi SW, Kim YI, Bagley PJ, Seitz HK, Russell RM, Selhub J and Mason JB: Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcohol Clin Exp Res. 24:259–264. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Dettmeyer R, Reith K and Madea B: Alcoholic cardiomyopathy versus chronic myocarditis-immunohistological investigations with LCA, CD3, CD68 and tenascin. Forensic Sci Int. 126:57–62. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Yang QF and Li YH: Roles of PPARs on regulating myocardial energy and lipid homeostasis. J Mol Med (Berl). 85:697–706. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Pellieux C, Montessuit C, Papageorgiou I and Lerch R: Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes. Pflugers Arch. 455:443–454. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Loichot C, Jesel L, Tesse A, Tabernero A, Schoonjans K, Roul G, Carpusca I, Auwerx J and Andriantsitohaina R: Deletion of peroxisome proliferator-activated receptor-alpha induces an alteration of cardiac functions. Am J Physiol Heart Circ Physiol. 291:H161–H166. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Melendez J, Welch S, Schaefer E, Moravec CS, Avraham S, Avraham H and Sussman MA: Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling. J Biol Chem. 277:45203–45210. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Preedy VR, Patel VB, Reilly ME, Richardson PJ, Falkous G and Mantle D: Oxidants, antioxidants and alcohol: Implications for skeletal and cardiac muscle. Front Biosci. 4:e58–e66. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Elamin E, Masclee A, Dekker J and Jonkers D: Ethanol disrupts intestinal epithelial tight junction integrity through intracellular calcium-mediated Rho/ROCK activation. Am J Physiol Gastrointest Liver Physiol. 306:G677–G685. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Wei B, Shang YX, Li M, Jiang J and Zhang H: Cytoskeleton changes of airway smooth muscle cells in juvenile rats with airway remodeling in asthma and the RhoA/ROCK signaling pathway mechanism. Genet Mol Res. 13:559–569. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Li Z, Liang J, Wu WK, Yu X, Yu J, Weng X and Shen J: Leptin activates RhoA/ROCK pathway to induce cytoskeleton remodeling in nucleus pulposus cells. Int J Mol Sci. 15:1176–1188. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Shimokawa H and Satoh K: Light and dark of reactive oxygen species for vascular function: 2014 ASVB (Asian Society of Vascular Biology). J Cardiovasc Pharmacol. 65:412–418. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Satoh K, Godo S, Saito H, Enkhjargal B and Shimokawa H: Dual roles of vascular-derived reactive oxygen species-with a special reference to hydrogen peroxide and cyclophilin A. J Mol Cell Cardiol. 73:50–56. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Higashi M, Shimokawa H, Hattori T, Hiroki J, Mukai Y, Morikawa K, Ichiki T, Takahashi S and Takeshita A: Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: Effect on endothelial NAD(P)H oxidase system. Circ Res. 93:767–775. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Fiarresga A, Cacela D, Galrinho A, Ramos R, de Sousa L, Bernardes L, Patrício L and Cruz Ferreira R: Alcohol septal ablation in obstructive hypertrophic cardiomyopathy: Four years of experience at a reference center. Rev Port Cardiol. 33:1–10. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Veselka J, Lawrenz T, Stellbrink C, Zemanek D, Branny M, Januska J, Sitar J, Dimitrow P, Krejci J, Dabrowski M, et al: Early outcomes of alcohol septal ablation for hypertrophic obstructive cardiomyopathy: A European multicenter and multinational study. Catheter Cardiovasc Interv. 84:101–107. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Pridemore WA, Chamlin MB, Kaylen MT and Andreev E: The effects of the 2006 Russian alcohol policy on alcohol-related mortality: An interrupted time series analysis. Alcohol Clin Exp Res. 38:257–266. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Kycina P and Murin J: Alcoholic cardiomyopathy and cardiovascular events-an insight from the Liptov region. Bratisl Med J. 114:337–341. 2013. View Article : Google Scholar

27 

Lessey-Morillon EC, Osborne LD, Monaghan-Benson E, Guilluy C, O'Brien ET, Superfine R and Burridge K: The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration. J Immunol. 192:3390–3398. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Duan X, Liu J, Dai XX, Liu HL, Cui XS, Kim NH, Wang ZB, Wang Q and Sun SC: Rho-GTPase effector ROCK phosphorylates cofilin in actin-meditated cytokinesis during mouse oocyte meiosis. Biol Reprod. 90:372014. View Article : Google Scholar : PubMed/NCBI

29 

Gabrielli L, Winter JL, Godoy I, McNab P, Padilla I, Cordova S, Rigotti P, Novoa U, Mora I, García L, Ocaranza MP and Jalil JE: Increased rho-kinase activity in hypertensive patients with left ventricular hypertrophy. Am J Hypertens. 27:838–845. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Hensel N, Stockbrügger I, Rademacher S, Broughton N, Brinkmann H, Grothe C and Claus P: Bilateral crosstalk of rho- and extracellular-signal-regulated-kinase (ERK) pathways is confined to an unidirectional mode in spinal muscular atrophy (SMA). Cell Signal. 26:540–548. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Morgan-Fisher M, Couchman JR and Yoneda A: Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion. J Biol Chem. 288:31229–31240. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Sasaki T, Oga T, Nakagaki K, Sakai K, Sumida K, Hoshino K, Miyawaki I, Saito K, Suto F and Ichinohe N: Developmental genetic profiles of glutamate receptor system, neuromodulator system, protector of normal tissue and mitochondria, and reelin in marmoset cortex: Potential molecular mechanisms of pruning phase of spines in primate synaptic formation process during the end of infancy and prepuberty (II). Biochem Biophys Res Commun. 444:307–310. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Gaio V, Nunes B, Fernandes A, Mendonça F, Horta Correia F, Beleza A, Gil AP, Bourbon M, Vicente A, Dias CM and Barreto da Silva M: Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: Results from the pilot study of the European health examination survey in portugal. Diabetol Metab Syndr. 6:232014. View Article : Google Scholar : PubMed/NCBI

34 

Liu PY and Liao JK: A method for measuring Rho kinase activity in tissues and cells. Methods Enzymol. 439:181–189. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Mertsch S and Thanos S: Opposing signaling of ROCK1 and ROCK2 determines the switching of substrate specificity and the mode of migration of glioblastoma cells. Mol Neurobiol. 49:900–915. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Shimizu T, Fukumoto Y, Tanaka S, Satoh K, Ikeda S and Shimokawa H: Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice. Arterioscler Thromb Vasc Biol. 33:2780–2791. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Laeno AM, Tamashiro DA and Alarcon VB: Rho-associated kinase activity is required for proper morphogenesis of the inner cell mass in the mouse blastocyst. Biol Reprod. 89:1222013. View Article : Google Scholar : PubMed/NCBI

38 

Al-Shboul O: The role of the RhoA/ROCK pathway in gender-dependent differences in gastric smooth muscle contraction. J Physiol Sci. 66:85–92. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Nzegwu MA, Okafor OC, Olusina DB, Ike V and Mbah AU: Dilated alcoholic cardiomyopathy and incidental lymphoma occuring in a 56 year old man who was being managed for hypertensive heart disease in Enugu Nigeria-a rare finding. Niger J Med. 20:494–497. 2011.PubMed/NCBI

40 

Jing L, Zhou LJ, Zhang FM, Li WM and Sang Y: Tenascin-x facilitates myocardial fibrosis and cardiac remodeling through transforming growth factor-β1 and peroxisome proliferator-activated receptor γ in alcoholic cardiomyopathy. Chin Med J (Engl). 124:390–395. 2011.PubMed/NCBI

41 

Tan Y, Li XK, Prabhu SD, Brittian KR, Chen Q, Yin X, McClain CJ, Zhou Z and Cai L: Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner. J Am Coll Cardiol. 59:1477–1486. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Ferrario CM: Cardiac remodelling and RAS inhibition. Ther Adv Cardiovasc Dis. 10:162–171. 2016. View Article : Google Scholar : PubMed/NCBI

43 

McArthur L, Chilton L, Smith GL and Nicklin SA: Electrical consequences of cardiac myocyte: Fibroblast coupling. Biochem Soc Trans. 43:513–518. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Chen Z, Liu S, Xia Y and Wu K: MiR-31 regulates Rho-associated kinase-myosin light chain (ROCK-MLC) pathway and inhibits gastric cancer invasion: Roles of RhoA. Med Sci Monit. 22:4679–4691. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Sabater-Molina M, Pérez-Sánchez I, Hernández Del Rincón JP and Gimeno JR: Genetics of hypertrophic cardiomyopathy: A review of current state. Clin Genet. 93:3–14. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Lopez NC, Ebensperger G, Herrera EA, Reyes RV, Calaf G, Cabello G, Moraga FA, Beñaldo FA, Diaz M, Parer JT and Llanos AJ: Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs. Am J Physiol Regul Integr Comp Physiol. 310:R1053–R1063. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Bhadriraju K, Yang M, Alom Ruiz S, Pirone D, Tan J and Chen CS: Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res. 313:3616–3623. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li L, Jing L, Zhao J, Lv J, Yang W, Li W and Zhou L: Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy. Exp Ther Med 18: 4313-4321, 2019.
APA
Li, L., Jing, L., Zhao, J., Lv, J., Yang, W., Li, W., & Zhou, L. (2019). Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy. Experimental and Therapeutic Medicine, 18, 4313-4321. https://doi.org/10.3892/etm.2019.8079
MLA
Li, L., Jing, L., Zhao, J., Lv, J., Yang, W., Li, W., Zhou, L."Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy". Experimental and Therapeutic Medicine 18.6 (2019): 4313-4321.
Chicago
Li, L., Jing, L., Zhao, J., Lv, J., Yang, W., Li, W., Zhou, L."Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4313-4321. https://doi.org/10.3892/etm.2019.8079
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Jing L, Zhao J, Lv J, Yang W, Li W and Zhou L: Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy. Exp Ther Med 18: 4313-4321, 2019.
APA
Li, L., Jing, L., Zhao, J., Lv, J., Yang, W., Li, W., & Zhou, L. (2019). Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy. Experimental and Therapeutic Medicine, 18, 4313-4321. https://doi.org/10.3892/etm.2019.8079
MLA
Li, L., Jing, L., Zhao, J., Lv, J., Yang, W., Li, W., Zhou, L."Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy". Experimental and Therapeutic Medicine 18.6 (2019): 4313-4321.
Chicago
Li, L., Jing, L., Zhao, J., Lv, J., Yang, W., Li, W., Zhou, L."Valsartan inhibits RhoA‑ROCK2‑MYL pathway in rat model of alcoholic cardiomyopathy". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4313-4321. https://doi.org/10.3892/etm.2019.8079
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team