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Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs

  • Authors:
    • Yong Liang
    • Chunsheng Li
    • Bo Liu
    • Qiang Zhang
    • Xiaoli Yuan
    • Yun Zhang
    • Jiyang Ling
    • Lianxing Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Beijing Chao‑Yang Hospital Affiliated to Capital Medical University, Beijing 100020, P.R. China, Department of Emergency, Beijing Tong‑Ren Hospital Affiliated to Capital Medical University, Beijing 100043, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4347-4355
    |
    Published online on: October 8, 2019
       https://doi.org/10.3892/etm.2019.8087
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Abstract

The present study aimed to explore the protective effects of extracorporeal membrane oxygenation (ECMO) on intestinal mucosal injury following cardiopulmonary resuscitation (CPR), and to assess the potential mechanisms involved. A total of 24 healthy adult domestic pigs were selected as the study subjects. A ventricular fibrillation model was induced through programmed electric stimulation. Subsequently, the animals were randomly divided into conventional CPR and CPR+ECMO groups (n=12 per group). The mortality and hemodynamic parameters of the two groups were compared. The expression levels of inflammatory cytokines in the serum and intestinal mucosa were detected by ELISAs. The intestinal mucosa was subjected to hematoxylin and eosin, and immunohistochemical staining, followed by electron microscopy, to assess the degree of apoptosis and necrosis. The animals in both groups recovered from the programmed ventricular fibrillation. In the CPR group, two animals died at 2 h and two more animals died a further 2 h later, resulting in a 33.3% mortality rate, whereas no cases of mortality were observed in the CPR+ECMO group. Compared with the animals in the CPR group, the hemodynamic parameters of the animals in the CPR+ECMO group revealed significantly improved outcomes. Multiple inflammatory factors (tumor necrosis factor α, interleukin‑1 and interleukin‑6), myeloperoxidase and malondialdehyde levels were decreased, whereas Na/Ca‑ATPase and superoxide dismutase levels were elevated in the intestinal mucosa of animals in the CPR+ECMO group compared with those in the CPR group. Additionally, pathological staining demonstrated that the intestinal mucosa tissue in the CPR+ECMO group exhibited less apoptosis, necrosis and inflammatory cell infiltration, which was further supported by a decrease in Bax expression and an increase in Bcl‑2 expression. Overall, ECMO after CPR reduced the intestinal mucosal barrier injury after spontaneous circulation recovery, and the mechanism involved decreased inflammation and apoptosis.
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1 

Mentzelopoulos SD and Zakynthinos SG: Post-cardiac arrest syndrome: Pathological processes, biomarkers and vasopressor support, and potential therapeutic targets. Resuscitation. 121:A12–A14. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Callaway CW, Donnino MW, Fink EL, Geocadin RG, Golan E, Kern KB, Leary M, Meurer WJ, Peberdy MA, Thompson TM and Zimmerman JL: Part 8: Post-cardiac arrest care: 2015 American heart association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 132 (18 Suppl 2). S465–S482. 2015.

3 

Perman SM, Grossestreuer AV, Wiebe DJ, Carr BG, Abella BS and Gaieski DF: The utility of therapeutic hypothermia for post-cardiac arrest syndrome patients with an initial nonshockable rhythm. Circulation. 132:2146–2151. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Jahandiez V, Cour M, Bochaton T, Abrial M, Loufouat J, Gharib A, Varennes A, Ovize M and Argaud L: Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition. Basic Res Cardiol. 112:352017. View Article : Google Scholar : PubMed/NCBI

5 

Bacon MK, Gray SB, Schwartz SM and Cooper DS: Extracorporeal membrane oxygenation (ECMO) support in special patient populations-the bidirectional glenn and fontan circulations. Front Pediatr. 6:2992018. View Article : Google Scholar : PubMed/NCBI

6 

Wu XY, Zhuang ZQ, Zheng RQ and Liu SQ: Extracorporeal membrane oxygenation as salvage therapy for acute massive pulmonary embolism after surgery for tibiofibular fractures. Chin Med J (Engl). 131:2611–2613. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Hernandez Conte AT, Ng D, Ramzy D, Dilibero D, LaBounty TM, Gaultier C and Behringer EC: Extracorporeal membrane oxygenation in a 29-year-old man with Pneumocystis jirovecii respiratory failure and AIDS. Tex Heart Inst J. 45:254–259. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Kim H, Paek JH, Song JH, Lee H, Jhee JH, Park S, Yun HR, Kee YK, Han SH, Yoo TH, et al: Permissive fluid volume in adult patients undergoing extracorporeal membrane oxygenation treatment. Crit Care. 22:2702018. View Article : Google Scholar : PubMed/NCBI

9 

Panda BR, Prabhu A, Provenzano S and Karl T: Use of extracorporeal life support for emergency coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 16:897–899. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Tan BK: Extracorporeal membrane oxygenation in cardiac arrest. Singapore Med J. 58:446–448. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Conrad SA and Rycus PT: Extracorporeal membrane oxygenation for refractory cardiac arrest. Ann Card Anaesth. 20 (Suppl 1):S4–S10. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Pan H, Chen D, Liu B, Xie X, Zhang J and Yang G: Effects of sodium hydrosulfide on intestinal mucosal injury in a rat model of cardiac arrest and cardiopulmonary resuscitation. Life Sci. 93:24–29. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Meek S and Morris F: ABC of clinical electrocardiography. Introduction. I-Leads, rate, rhythm, and cardiac axis. BMJ. 324:415–418. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Maudet L, Carron PN and Trueb L: Cardiopulmonary resuscitation: The essential of 2015 guidelines. Rev Med Suisse. 12:313–317. 2016.(In French). PubMed/NCBI

15 

Hang CC, Li CS, Wu CJ and Yang J: Acute kidney injury after cardiac arrest of ventricular fibrillation and asphyxiation swine model. Am J Emerg Med. 32:208–215. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Wu CJ, Li CS, Zhang Y and Yang J: Application of positron emission tomography in the detection of myocardial metabolism in pig ventricular fibrillation and asphyxiation cardiac arrest models after resuscitation. Biomed Environ Sci. 27:531–536. 2014.PubMed/NCBI

17 

Gawlinski A: Measuring cardiac output: Intermittent bolus thermodilution method. Crit Care Nurse. 20:118–120, 122–114. 2000.PubMed/NCBI

18 

Chen Y, Huang Y, Lu X, Wang G and Chi P: Antitumor effects of the silencing of programmed cell death ligand 1 in colorectal cancer via immunoregulation. Oncol Rep. 40:3370–3380. 2018.PubMed/NCBI

19 

MacFie J: Enteral versus parenteral nutrition: The significance of bacterial translocation and gut-barrier function. Nutrition. 16:606–611. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Schroeder DC, Maul AC, Mahabir E, Koxholt I, Yan X, Padosch SA, Herff H, Bultmann-Mellin I, Sterner-Kock A, Annecke T, et al: Evaluation of small intestinal damage in a rat model of 6 Minutes cardiac arrest. BMC Anesthesiol. 18:612018. View Article : Google Scholar : PubMed/NCBI

21 

Wurm R, Cho A, Arfsten H, van Tulder R, Wallmüller C, Steininger P, Sterz F, Tendl K, Balassy C, Distelmaier K, et al: Non-occlusive mesenteric ischaemia in out of hospital cardiac arrest survivors. Eur Heart J Acute Cardiovasc Care. 7:450–458. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Korth U, Krieter H, Denz C, Janke C, Ellinger K, Bertsch T, Henn C and Klein J: Intestinal ischaemia during cardiac arrest and resuscitation: Comparative analysis of extracellular metabolites by microdialysis. Resuscitation. 58:209–217. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Patil KD, Halperin HR and Becker LB: Cardiac arrest: Resuscitation and reperfusion. Circ Res. 116:2041–2049. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Parks DA and Granger DN: Contributions of ischemia and reperfusion to mucosal lesion formation. Am J Physiol. 250:G749–G753. 1986.PubMed/NCBI

25 

Millar JE, Fanning JP, McDonald CI, McAuley DF and Fraser JF: The inflammatory response to extracorporeal membrane oxygenation (ECMO): A review of the pathophysiology. Crit Care. 20:3872016. View Article : Google Scholar : PubMed/NCBI

26 

Tu Y, Jin Q, Sun R and Li Q: Extracorporeal membrane oxygenation support for a multitrauma patient with ARDS: A case report and literature review. Exp Ther Med. 15:2062–2065. 2018.PubMed/NCBI

27 

Tillmann BW, Klingel ML, Iansavichene AE, Ball IM and Nagpal AD: Extracorporeal membrane oxygenation (ECMO) as a treatment strategy for severe acute respiratory distress syndrome (ARDS) in the low tidal volume era: A systematic review. J Crit Care. 41:64–71. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Liu Q, Kong AL, Chen R, Qian C, Liu SW, Sun BG, Wang LX, Song LS and Hong J: Propofol and arrhythmias: Two sides of the coin. Acta Pharmacol Sin. 32:817–823. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Warpechowski P, dos Santos AT, Pereira PJ and de Lima GG: Effects of propofol on the cardiac conduction system. Rev Bras Anestesiol. 60:438–444. 2010.(In English, Portuguese). View Article : Google Scholar : PubMed/NCBI

30 

Van Hauwermeiren F, Vandenbroucke RE, Grine L, Lodens S, Van Wonterghem E, De Rycke R, De Geest N, Hassan B and Libert C: TNFR1-induced lethal inflammation is mediated by goblet and Paneth cell dysfunction. Mucosal Immunol. 8:828–840. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Xiong W, Xu S, Li H and Liang K: Moderate hypothermia ameliorates enterocyte mitochondrial dysfunction in severe shock and reperfusion. J Surg Res. 200:250–259. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Stub D, Bernard S, Duffy SJ and Kaye DM: Post cardiac arrest syndrome: A review of therapeutic strategies. Circulation. 123:1428–1435. 2011. View Article : Google Scholar : PubMed/NCBI

33 

de Oliveira THC, Souza DG, Teixeira MM and Amaral FA: Tissue dependent role of PTX3 during ischemia-reperfusion injury. Front Immunol. 10:14612019. View Article : Google Scholar : PubMed/NCBI

34 

Lowe PP, Gyongyosi B, Satishchandran A, Iracheta-Vellve A, Ambade A, Kodys K, Catalano D, Ward DV and Szabo G: Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. PLoS One. 12:e01745442017. View Article : Google Scholar : PubMed/NCBI

35 

D'Elia RV, Harrison K, Oyston PC, Lukaszewski RA and Clark GC: Targeting the ‘cytokine storm’ for therapeutic benefit. Clin Vaccine Immunol. 20:319–327. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Zhu G, Wang X, Wu S, Li X and Li Q: Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. Phytother Res. 28:179–186. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Martens EC, Neumann M and Desai MS: Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier. Nat Rev Microbiol. 16:457–470. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liang Y, Li C, Liu B, Zhang Q, Yuan X, Zhang Y, Ling J and Zhao L: Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs. Exp Ther Med 18: 4347-4355, 2019.
APA
Liang, Y., Li, C., Liu, B., Zhang, Q., Yuan, X., Zhang, Y. ... Zhao, L. (2019). Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs. Experimental and Therapeutic Medicine, 18, 4347-4355. https://doi.org/10.3892/etm.2019.8087
MLA
Liang, Y., Li, C., Liu, B., Zhang, Q., Yuan, X., Zhang, Y., Ling, J., Zhao, L."Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs". Experimental and Therapeutic Medicine 18.6 (2019): 4347-4355.
Chicago
Liang, Y., Li, C., Liu, B., Zhang, Q., Yuan, X., Zhang, Y., Ling, J., Zhao, L."Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4347-4355. https://doi.org/10.3892/etm.2019.8087
Copy and paste a formatted citation
x
Spandidos Publications style
Liang Y, Li C, Liu B, Zhang Q, Yuan X, Zhang Y, Ling J and Zhao L: Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs. Exp Ther Med 18: 4347-4355, 2019.
APA
Liang, Y., Li, C., Liu, B., Zhang, Q., Yuan, X., Zhang, Y. ... Zhao, L. (2019). Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs. Experimental and Therapeutic Medicine, 18, 4347-4355. https://doi.org/10.3892/etm.2019.8087
MLA
Liang, Y., Li, C., Liu, B., Zhang, Q., Yuan, X., Zhang, Y., Ling, J., Zhao, L."Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs". Experimental and Therapeutic Medicine 18.6 (2019): 4347-4355.
Chicago
Liang, Y., Li, C., Liu, B., Zhang, Q., Yuan, X., Zhang, Y., Ling, J., Zhao, L."Protective effect of extracorporeal membrane oxygenation on intestinal mucosal injury after cardiopulmonary resuscitation in pigs". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4347-4355. https://doi.org/10.3892/etm.2019.8087
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