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Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas

  • Authors:
    • Jia Ding
    • Yuwen Chen
    • Yuan Gao
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Unit, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, P.R. China, Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4340-4346
    |
    Published online on: October 9, 2019
       https://doi.org/10.3892/etm.2019.8091
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Abstract

Effects of propofol, midazolam and dexmedetomidine on patients with sepsis in intensive care unit (ICU) and on arterial blood gas (ABG) were studied. In total 429 ICU patients with sepsis, admitted to Renji Hospital, School of Medicine, Shanghai Jiaotong University from May 2015 to January 2019, were selected as research subjects for a prospective analysis. All patients received basic treatment, such as anti‑infection treatment, correction of shock and improvement of microcirculation. One hundred and fifty‑two patients who were treated with propofol for sedation served as group A, 146 patients who were treated with midazolam for sedation served as group B, and 131 patients who were treated with dexmedetomidine for sedation served as group C. The three groups of patients were compared in terms of diastolic blood pressure (DBP), systolic blood pressure (SBP), heart rate (HR), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), cardiac troponin T (cTnT) and creatine kinase‑MB (CK‑MB) before and after treatment. APACHE Ⅱ score was used to evaluate the sedative effects. The wake‑up time of the patients, the length of ICU stay and the adverse reactions were recorded. There was no significant difference among groups A, B and C in terms of HR, SBP, DBP, PaO2, PaCO2, cTnT, CK‑MB and APACHE Ⅱ score before treatment, and SBP, DBP, cTnT and HR after treatment (P>0.050). After treatment, there was no significant difference between groups A and B with respect to CK‑MB and APACHE Ⅱ score (P>0.050). The wake‑up time in group A was significantly longer than that in groups B and C (P<0.001). In conclusion, propofol, midazolam and dexmedetomidine are effective and safe in the sedative treatment of ICU patients with sepsis, but dexmedetomidine has the best effect on protecting blood pressure and cardiac functions, which is worthy of use in the clinic.
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1 

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al: The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 315:801–810. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC and Reinhart K; International Forum of Acute Care Trialists, : International Forum of Acute Care Trialists: Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 193:259–272. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Fleischmann C, Thomas-Rueddel DO, Hartmann M, Hartog CS, Welte T, Heublein S, Dennler U and Reinhart K: Hospital incidence and mortality rates of sepsis: An analysis of hospital episode (DRG) statistics in Germany from 2007 to 2013. Dtsch Arztebl Int. 113:159–166. 2016.PubMed/NCBI

4 

Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, Kadri SS, Angus DC, Danner RL, Fiore AE, et al CDC Prevention Epicenter Program, : Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009–2014. JAMA. 318:1241–1249. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Polat G, Ugan RA, Cadirci E and Halici Z: Sepsis and septic shock: Current treatment strategies and new approaches. Eurasian J Med. 49:53–58. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Kadri SS, Rhee C, Strich JR, Morales MK, Hohmann S, Menchaca J, Suffredini AF, Danner RL and Klompas M: Estimating ten-year trends in septic shock incidence and mortality in United States Academic Medical Centers using clinical data. Chest. 151:278–285. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Marik PE, Khangoora V, Rivera R, Hooper MH and Catravas J: Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: A retrospective before-after study. Chest. 151:1229–1238. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Stoller J, Halpin L, Weis M, Aplin B, Qu W, Georgescu C and Nazzal M: Epidemiology of severe sepsis: 2008–2012. J Crit Care. 31:58–62. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Anderson BJ, Reilly JP, Shashaty MGS, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, et al: Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis. J Crit Care. 36:18–23. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Steingrub JS, Lagu T, Rothberg MB, Nathanson BH, Raghunathan K and Lindenauer PK: Treatment with neuromuscular blocking agents and the risk of in-hospital mortality among mechanically ventilated patients with severe sepsis. Crit Care Med. 42:90–96. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Marler J, Mohrien K, Kimmons LA, Vandigo JE, Oliphant CS, Boucher AN and Jones GM: Effects of propofol on vasopressor use in patients with sepsis and severe sepsis: A pilot study. J Crit Care. 35:155–160. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Kawazoe Y, Miyamoto K, Morimoto T, Yamamoto T, Fuke A, Hashimoto A, Koami H, Beppu S, Katayama Y, Itoh M, et al Dexmedetomidine for Sepsis in Intensive Care Unit Randomized Evaluation (DESIRE) Trial Investigators, : Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: A randomized clinical trial. JAMA. 317:1321–1328. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Fernando SM, Rochwerg B and Seely AJE: Clinical implications of the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). CMAJ. 190:E1058–E1059. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Yamamura H, Kawazoe Y and Morimoto T: Dexmedetomidine in patients with sepsis requiring mechanical ventilation-reply. JAMA. 318:480. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, Rubenfeld G, Kahn JM, Shankar-Hari M, Singer M, et al: Assessment of clinical criteria for sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 315:762–774. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Godinjak A, Iglica A, Rama A, Tančica I, Jusufović S, Ajanović A and Kukuljac A: Predictive value of SAPS II and APACHE II scoring systems for patient outcome in a medical intensive care unit. Acta Med Acad. 45:97–103. 2016.PubMed/NCBI

17 

van Vught LA, Klein Klouwenberg PM, Spitoni C, Scicluna BP, Wiewel MA, Horn J, Schultz MJ, Nürnberg P, Bonten MJ, Cremer OL, et al MARS Consortium, : Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis. JAMA. 315:1469–1479. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Braun D: A retrospective review of the sepsis definition after publication of sepsis-3. Am J Med. 132:382–384. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Kim KS, Suh GJ, Kim K, Kwon WY, Shin J, Jo YH, Lee JH and Lee H: Quick Sepsis-related Organ Failure Assessment score is not sensitive enough to predict 28-day mortality in emergency department patients with sepsis: A retrospective review. Clin Exp Emerg Med. 6:77–83. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Vaez H, Rameshrad M, Najafi M, Barar J, Barzegari A and Garjani A: Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart. Eur J Pharmacol. 772:115–123. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Abdelmalik PA and Rakocevic G: Propofol as a risk factor for ICU-acquired weakness in septic patients with acute respiratory failure. Can J Neurol Sci. 44:295–303. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Zamani MM, Keshavarz-Fathi M, Fakhri-Bafghi MS, Hirbod-Mobarakeh A, Rezaei N, Bahrami A and Nader ND: Survival benefits of dexmedetomidine used for sedating septic patients in intensive care setting: A systematic review. J Crit Care. 32:93–100. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Chen Y, Zhang X, Zhang B, He G, Zhou L and Xie Y: Dexme-detomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2-STAT3 pathway. Drug Des Devel Ther. 11:2787–2799. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Sonneville R, de Montmollin E, Poujade J, Garrouste-Orgeas M, Souweine B, Darmon M, Mariotte E, Argaud L, Barbier F, Goldgran-Toledano D, et al: Potentially modifiable factors contributing to sepsis-associated encephalopathy. Intensive Care Med. 43:1075–1084. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Ren X, Ma H and Zuo Z: Dexmedetomidine postconditioning reduces brain injury after brain hypoxia-ischemia in neonatal rats. J Neuroimmune Pharmacol. 11:238–247. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Barnes J, Hunter J, Harris S, Shankar-Hari M, Diouf E, Jammer I, Kalkman C, Klein AA, Corcoran T, Dieleman S, et al StEP- COMPAC group, : Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: Infection and sepsis. Br J Anaesth. 122:500–508. 2019. View Article : Google Scholar : PubMed/NCBI

27 

McGregor BA, Murphy KM, Albano DL and Ceballos RM: Stress, cortisol, and B lymphocytes: A novel approach to understanding academic stress and immune function. Stress. 19:185–191. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, Angus DC, Rubenfeld GD and Singer M; Sepsis Definitions Task Force, : Developing a new definition and assessing new clinical criteria for septic shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 315:775–787. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ding J, Chen Y and Gao Y: Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas. Exp Ther Med 18: 4340-4346, 2019.
APA
Ding, J., Chen, Y., & Gao, Y. (2019). Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas. Experimental and Therapeutic Medicine, 18, 4340-4346. https://doi.org/10.3892/etm.2019.8091
MLA
Ding, J., Chen, Y., Gao, Y."Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas". Experimental and Therapeutic Medicine 18.6 (2019): 4340-4346.
Chicago
Ding, J., Chen, Y., Gao, Y."Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4340-4346. https://doi.org/10.3892/etm.2019.8091
Copy and paste a formatted citation
x
Spandidos Publications style
Ding J, Chen Y and Gao Y: Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas. Exp Ther Med 18: 4340-4346, 2019.
APA
Ding, J., Chen, Y., & Gao, Y. (2019). Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas. Experimental and Therapeutic Medicine, 18, 4340-4346. https://doi.org/10.3892/etm.2019.8091
MLA
Ding, J., Chen, Y., Gao, Y."Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas". Experimental and Therapeutic Medicine 18.6 (2019): 4340-4346.
Chicago
Ding, J., Chen, Y., Gao, Y."Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4340-4346. https://doi.org/10.3892/etm.2019.8091
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