Open Access

Predictive value of procalcitonin in chronic allograft dysfunction in kidney transplant recipients

  • Authors:
    • Jing Yao
    • Lijuan Jiang
    • Dong Xue
    • Yanbei Sun
  • View Affiliations

  • Published online on: October 21, 2019     https://doi.org/10.3892/etm.2019.8113
  • Pages: 4603-4608
  • Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study was designed to determine the potential role of circulating procalcitonin (PCT) in predicting chronic allograft dysfunction (CAD) in kidney transplant recipients (KTRs). A total of 87 KTRs were retrospectively analyzed and divided into a CAD and a non‑CAD (normal renal function) group. Clinical features and inflammatory markers were compared between the groups, including PCT, white blood cell count, C‑reactive protein, neutrophil percentage (N%) and lipoprotein(a) [Lp(a)], and the receiver operating characteristic (ROC) curve for CAD prediction was plotted. Univariate and multivariate logistic regression analyses were used to analyze the relevant risk factors for CAD. The results indicated that i) the values of these indicators in the CAD group, including the male ratio, years after transplantation, PCT, N% and Lp(a), were significantly higher than those in the non‑CAD group, while the body mass index, aspartate aminotransferase, high‑density lipoprotein and low‑density lipoprotein were significantly lower; ii) PCT and Lp(a) were able to predict CAD with an area under the ROC curve of 0.893 and 0.770, respectively; iii) multivariate logistic regression analysis of factors influencing CAD in KTRs suggested that elevated PCT was an independent risk factor. In KTRs, PCT was identified as a potential biomarker for predicting CAD.

Related Articles

Journal Cover

December 2019
Volume 18 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Yao, J., Jiang, L., Xue, D., & Sun, Y. (2019). Predictive value of procalcitonin in chronic allograft dysfunction in kidney transplant recipients. Experimental and Therapeutic Medicine, 18, 4603-4608. https://doi.org/10.3892/etm.2019.8113
MLA
Yao, J., Jiang, L., Xue, D., Sun, Y."Predictive value of procalcitonin in chronic allograft dysfunction in kidney transplant recipients". Experimental and Therapeutic Medicine 18.6 (2019): 4603-4608.
Chicago
Yao, J., Jiang, L., Xue, D., Sun, Y."Predictive value of procalcitonin in chronic allograft dysfunction in kidney transplant recipients". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4603-4608. https://doi.org/10.3892/etm.2019.8113