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Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations

  • Authors:
    • Dongdong Wang
    • Xiao Chen
    • Hong Xu
    • Zhiping Li
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Children's Hospital of Fudan University, Shanghai 201102, P.R. China, Department of Nephrology and Rheumatology, Children's Hospital of Fudan University, Shanghai 201102, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4653-4660
    |
    Published online on: October 25, 2019
       https://doi.org/10.3892/etm.2019.8129
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Abstract

Pediatric patients with systemic‑onset juvenile idiopathic arthritis (SOJIA) may be treated with tacrolimus. However, the therapeutic range for tacrolimus is narrow with considerable inter‑ and intra‑individual variability, making it difficult to formulate an ideal dosage regimen for personalized treatment. The purpose of the present study was to set up a population pharmacokinetics (PPK) model of tacrolimus treatment for SOJIA to determine the optimal initial dosage. Patients with SOJIA were analyzed using non‑linear mixed‑effects modeling. Different regimens were analyzed using Monte Carlo simulation with concentration profiles. A first‑order absorption and elimination one‑compartment model was selected as the most appropriate model for SOJIA. Based on initial dosage recommendations, the regimen of 0.5 mg every 24 h (q24h) appeared to be most suitable for subjects with a body weight of 5 kg, while the 0.5 mg q12h regimen was most suitable for subjects with a body weight of 15‑25 kg, the 1/0.5 mg q24h regimen was appropriate for the 26‑35 kg group and the 1 mg q12h regimen was suitable for the subjects with a body weight of 36‑50 kg. To the best of our knowledge, the present study established the first PPK model of tacrolimus treatment that may be used for the selection of the initial dose based on body weight of pediatric patients with SOJIA.
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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Chen X, Xu H and Li Z: Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations. Exp Ther Med 18: 4653-4660, 2019.
APA
Wang, D., Chen, X., Xu, H., & Li, Z. (2019). Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations. Experimental and Therapeutic Medicine, 18, 4653-4660. https://doi.org/10.3892/etm.2019.8129
MLA
Wang, D., Chen, X., Xu, H., Li, Z."Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations". Experimental and Therapeutic Medicine 18.6 (2019): 4653-4660.
Chicago
Wang, D., Chen, X., Xu, H., Li, Z."Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4653-4660. https://doi.org/10.3892/etm.2019.8129
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Chen X, Xu H and Li Z: Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations. Exp Ther Med 18: 4653-4660, 2019.
APA
Wang, D., Chen, X., Xu, H., & Li, Z. (2019). Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations. Experimental and Therapeutic Medicine, 18, 4653-4660. https://doi.org/10.3892/etm.2019.8129
MLA
Wang, D., Chen, X., Xu, H., Li, Z."Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations". Experimental and Therapeutic Medicine 18.6 (2019): 4653-4660.
Chicago
Wang, D., Chen, X., Xu, H., Li, Z."Population pharmacokinetics of tacrolimus in pediatric patients with systemic‑onset juvenile idiopathic arthritis: Initial dosage recommendations". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4653-4660. https://doi.org/10.3892/etm.2019.8129
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