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A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma

  • Authors:
    • Lizhong Zeng
    • Wei Wang
    • Yang Chen
    • Xin Lv
    • Jingyan Yuan
    • Ruiying Sun
    • Shuanying Yang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi 710000, P.R. China
    Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4852-4864
    |
    Published online on: October 25, 2019
       https://doi.org/10.3892/etm.2019.8138
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Abstract

An increasing number of studies have indicated that the abnormal expression of certain long non‑coding RNAs (lncRNAs) is linked to the overall survival (OS) of patients with lung adenocarcinoma (LUAD). The aim of the present study was to establish an lncRNA signature to predict the survival of patients with LUAD. The gene expression profiles and associated clinical information of patients with LUAD were downloaded from The Cancer Genome Atlas database. The cohort was randomly sub‑divided into training and verification cohorts. Univariate Cox regression analysis was performed on differentially expressed lncRNAs in the training cohort to select candidate lncRNAs closely associated with survival. Next, a risk score (RS) model consisting of 5 lncRNAs was established by multivariate Cox regression analysis on candidate lncRNAs. Using the median RS obtained from the training cohort as a cut‑off point, patients were classified into high‑ and low‑risk groups. Kaplan‑Meier survival analysis revealed a significant difference in OS between high‑ and low‑risk groups. The survival prediction ability of the 5‑lncRNA signature was further tested in the verification and total cohorts. The results proved that the 5‑lncRNA signature had good reliability and stability in survival prediction for patients with LUAD. The univariate Cox regression analysis for the 5‑lncRNA signature in each cohort indicated that the 5‑lncRNA signature was closely associated with survival. Multivariate Cox regression analysis and stratification analysis proved that the prognostic signature was an independent predictor of survival for patients with LUAD. In addition, functional enrichment analysis indicated that the 5 prognostic lncRNAs may be involved in the tumorigenesis of LUAD through cancer‑associated pathways and biological processes. Taken together, the present study provided a 5‑lncRNA signature that may serve as an independent survival predictor for patients with LUAD.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Sholl LM: The molecular pathology of lung cancer. Surg Pathol Clin. 9:353–378. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Mao Y, Yang D, He J and Krasna MJ: Epidemiology of lung cancer. Surg Oncol Clin N Am. 25:439–445. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Puri T: Targeted therapy in nonsmall cell lung cancer. Indian J Cancer. 54:83–88. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Jathar S, Kumar V, Srivastava J and Tripathi V: Technological developments in lncRNA biology. Adv Exp Med Biol. 1008:283–323. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Jarroux J, Morillon A and Pinskaya M: History, discovery, and classification of lncRNAs. Adv Exp Med Biol. 1008:1–46. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Bhan A, Soleimani M and Mandal SS: Long noncoding RNA and cancer: A New Paradigm. Cancer Res. 77:3965–3981. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Liu Y, Sharma S and Watabe K: Roles of lncRNA in breast cancer. Front Biosci (Schol Ed). 7:94–108. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Thin KZ, Liu X, Feng X, Raveendran S and Tu JC: LncRNA- DANCR: A valuable cancer related long non-coding RNA for human cancers. Pathol Res Pract. 214:801–805. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Gibb EA, Brown CJ and Lam WL: The functional role of long non-coding RNA in human carcinomas. Mol Cancer. 10:382011. View Article : Google Scholar : PubMed/NCBI

12 

Balas MM and Johnson AM: Exploring the mechanisms behind long noncoding RNAs and cancer. Noncoding RNA Res. 3:108–117. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Qi G, Kong W, Mou X and Wang S: A new method for excavating feature lncRNA in lung adenocarcinoma based on pathway crosstalk analysis. J Cell Biochem. 120:9034–9046. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Peng W, Wang J, Shan B, Peng Z, Dong Y, Shi W, He D, Cheng Y, Zhao W, Zhang C, et al: Diagnostic and prognostic potential of circulating long non-coding RNAs in non small cell lung cancer. Cell Physiol Biochem. 49:816–827. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Dai SP, Jin J and Li WM: Diagnostic efficacy of long non-coding RNA in lung cancer: A systematic review and meta-analysis. Postgrad Med J. 94:578–587. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Pan X, Zheng G and Gao C: LncRNA PVT1: A novel therapeutic target for cancers. Clin Lab. 64:655–662. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Song P, Jiang B, Liu Z, Ding J, Liu S and Guan W: A three- lncRNA expression signature associated with the prognosis of gastric cancer patients. Cancer Med. 6:1154–1164. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Bao Z, Zhang W and Dong D: A potential prognostic lncRNA signature for predicting survival in patients with bladder urothelial carcinoma. Oncotarget. 8:10485–10497. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Gu JX, Zhang X, Miao RC, Xiang XH, Fu YN, Zhang JY, Liu C and Qu K: Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma. World J Gastroenterol. 25:220–232. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Luo D, Deng B, Weng M, Luo Z and Nie X: A prognostic 4-lncRNA expression signature for lung squamous cell carcinoma. Artif Cells Nanomed Biotechnol. 46:1207–1214. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Lu T, Wang Y, Chen D, Liu J and Jiao W: Potential clinical application of lncRNAs in non-small cell lung cancer. Onco Targets Ther. 11:8045–8052. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Miao R, Ge C, Zhang X, He Y, Ma X, Xiang X, Gu J, Fu Y, Qu K, Liu C, et al: Combined eight-long noncoding RNA signature: A new risk score predicting prognosis in elderly non-small cell lung cancer patients. Aging (Albany NY). 11:467–479. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Li X, Li B, Ran P and Wang L: Identification of ceRNA network based on a RNA-seq shows prognostic lncRNA biomarkers in human lung adenocarcinoma. Oncol Lett. 16:5697–5708. 2018.PubMed/NCBI

24 

Kumar P, Khadirnaikar S and Shukla SK: A novel LncRNA- based prognostic score reveals TP53-dependent subtype of lung adenocarcinoma with poor survival. J Cell Physiol. Feb 10–2019.doi: 10.1002/jcp.28260 (Epub ahead of print). View Article : Google Scholar

25 

Songyang Y, Zhu W, Liu C, Li LL, Hu W, Zhou Q, Zhang H, Li W and Li D: Large-scale gene expression analysis reveals robust gene signatures for prognosis prediction in lung adenocarcinoma. PeerJ. 7:e69802019. View Article : Google Scholar : PubMed/NCBI

26 

Li YY, Yang C, Zhou P, Zhang S, Yao Y and Li D: Genome-scale analysis to identify prognostic markers and predict the survival of lung adenocarcinoma. J Cell Biochem. 119:8909–8921. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Huang PH: Asymptotics of AIC, BIC, and RMSEA for model selection in structural equation modeling. Psychometrika. 82:407–426. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Sing T, Sander O, Beerenwinkel N and Lengauer T: ROCR: Visualizing classifier performance in R. Bioinformatics. 21:3940–3941. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Huang DW, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID bioinformatics resources: Expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 35:W169–W175. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Wu J, Mao X, Cai T, Luo J and Wei L: KOBAS server: A web-based platform for automated annotation and pathway identification. Nucleic Acids Res. 34:W720–W724. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Merico D, Isserlin R, Stueker O, Emili A and Bader GD: Enrichment map: A network-based method for gene-set enrichment visualization and interpretation. PLoS One. 5:e139842010. View Article : Google Scholar : PubMed/NCBI

33 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Ito K and Murphy D: Application of ggplot2 to pharmacometric graphics. CPT Pharmacometrics Syst Pharmacol. 2:e792013. View Article : Google Scholar : PubMed/NCBI

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Forrest ME and Khalil AM: Review: Regulation of the cancer epigenome by long non-coding RNAs. Cancer Lett. 407:106–112. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Yang G, Lu X and Yuan L: LncRNA: A link between RNA and cancer. Biochim Biophys Acta. 1839:1097–1109. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Schmitz SU, Grote P and Herrmann BG: Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci. 73:2491–2509. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Zhang H, Chen Z, Wang X, Huang Z, He Z and Chen Y: Long non-coding RNA: A new player in cancer. J Hematol Oncol. 6:372013. View Article : Google Scholar : PubMed/NCBI

40 

Chen W, You J, Zheng Q and Zhu YY: Downregulation of lncRNA OGFRP1 inhibits hepatocellular carcinoma progression by AKT/mTOR and Wnt/β-catenin signaling pathways. Cancer Manag Res. 10:1817–1826. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Lv Y, Chen S, Wu J, Lin R, Zhou L, Chen G, Chen H and Ke Y: Upregulation of long non-coding RNA OGFRP1 facilitates endometrial cancer by regulating miR-124-3p/SIRT1 axis and by activating PI3K/AKT/GSK-3beta pathway. Artif Cells Nanomed Biotechnol. 47:2083–2090. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Tang LX, Chen GH, Li H, He P, Zhang Y and Xu XW: Long non-coding RNA OGFRP1 regulates LYPD3 expression by sponging miR-124-3p and promotes non-small cell lung cancer progression. Biochem Biophys Res Commun. 505:578–585. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Ferré F, Colantoni A and Helmer-Citterich M: Revealing protein-lncRNA interaction. Brief Bioinform. 17:106–116. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Joerger AC and Fersht AR: The p53 pathway: Origins, inactivation in cancer, and emerging therapeutic approaches. Annu Rev Biochem. 85:375–404. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Williams GH and Stoeber K: The cell cycle and cancer. J Pathol. 226:352–364. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zeng L, Wang W, Chen Y, Lv X, Yuan J, Sun R and Yang S: A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma . Exp Ther Med 18: 4852-4864, 2019.
APA
Zeng, L., Wang, W., Chen, Y., Lv, X., Yuan, J., Sun, R., & Yang, S. (2019). A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma . Experimental and Therapeutic Medicine, 18, 4852-4864. https://doi.org/10.3892/etm.2019.8138
MLA
Zeng, L., Wang, W., Chen, Y., Lv, X., Yuan, J., Sun, R., Yang, S."A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma ". Experimental and Therapeutic Medicine 18.6 (2019): 4852-4864.
Chicago
Zeng, L., Wang, W., Chen, Y., Lv, X., Yuan, J., Sun, R., Yang, S."A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma ". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4852-4864. https://doi.org/10.3892/etm.2019.8138
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng L, Wang W, Chen Y, Lv X, Yuan J, Sun R and Yang S: A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma . Exp Ther Med 18: 4852-4864, 2019.
APA
Zeng, L., Wang, W., Chen, Y., Lv, X., Yuan, J., Sun, R., & Yang, S. (2019). A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma . Experimental and Therapeutic Medicine, 18, 4852-4864. https://doi.org/10.3892/etm.2019.8138
MLA
Zeng, L., Wang, W., Chen, Y., Lv, X., Yuan, J., Sun, R., Yang, S."A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma ". Experimental and Therapeutic Medicine 18.6 (2019): 4852-4864.
Chicago
Zeng, L., Wang, W., Chen, Y., Lv, X., Yuan, J., Sun, R., Yang, S."A five‑long non‑coding RNA signature with the ability to predict overall survival of patients with lung adenocarcinoma ". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4852-4864. https://doi.org/10.3892/etm.2019.8138
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