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Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats

  • Authors:
    • Shuiqin Li
    • Yan Ou
    • Chaonan Li
    • Wei Wei
    • Lei Lei
    • Qiaojun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation Medicine, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710077, P.R. China, Department of Nephrology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4682-4688
    |
    Published online on: October 30, 2019
       https://doi.org/10.3892/etm.2019.8147
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Abstract

Acute spinal cord injury (SCI) has a high rate of disability and mortality. Although secondary SCI results in local tissue hypoxia and the release of inflammatory mediators, it is both controllable and reversible. Therefore, timely rehabilitation treatment is beneficial for the partial recovery of patients with SCI. The present study aimed to investigate the use of methylprednisolone combined with high‑frequency electrotherapy as a method of rehabilitation treatment in rats with SCI. The rat SCI model was prepared using the modified Allen's method with the animals randomly divided into the following 4 groups (n=10 for each group): SCI; methylprednisolone (300 mg/kg); high‑frequency electrotherapy; and combination treatment with electrotherapy combined with methylprednisolone (300 mg/kg). The Basso, Beattie and Bresnahan (BBB) score, somatosensory evoked potential (SEP) and motor evoked potential (MEP) were used to assess spinal function. Brain‑derived neurotrophic factor (BDNF) and NF‑κB expression levels were detected using reverse transcription‑quantitative PCR and western blotting. Tumor necrosis factor (TNF)‑α and IL‑2 expression levels were determined by ELISA, and caspase 3 activity was also assessed. In all treatment groups, BDNF mRNA and protein expression levels were significantly increased, whilst those of NF‑κB were reduced. Additionally, an elevated BBB score, improved SEPs and MEPs, inhibited caspase 3 activity and downregulated TNF‑α and IL‑2 expression levels were observed, compared with the SCI group (P<0.05). However, the combination group exhibited more significant effects on SCI. In conclusion, methylprednisolone combined with high frequency electrotherapy may improve the symptoms of SCI by increasing the expression level of BDNF, reducing that of NF‑κB, and suppressing the secretion of inflammatory factors.
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View References

1 

Burkovskiy I, Zhou J and Lehmann C: Experimental cannabinoid 2 receptor inhibition in CNS injury-induced immunodeficiency syndrome. Microcirculation. 23:283–292. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Cheah M, Andrews MR, Chew DJ, Moloney EB, Verhaagen J, Fässler R and Fawcett JW: Expression of an activated integrin promotes long-distance sensory axon regeneration in the spinal cord. J Neurosci. 36:7283–7297. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Fang H, Zhang JC, Yang M, Li HF, Zhang JP, Zhang FX, Wang QY, Wang RR and Liu J: Perfusion of gastrodin in abdominal aorta for alleviating spinal cord ischemia reperfusion injury. Asian Pac J Trop Med. 9:688–693. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Qin W, Li X, Peng Y, Harlow LM, Ren Y, Wu Y, Li J, Qin Y, Sun J, Zheng S, et al: Sclerostin antibody preserves the morphology and structure of osteocytes and blocks the severe skeletal deterioration after motor-complete spinal cord injury in rats. J Bone Miner Res. 31:14822016. View Article : Google Scholar : PubMed/NCBI

5 

Rao SN and Pearse DD: Pearse, regulating axonal responses to injury: The intersection between signaling pathways involved in axon myelination and the inhibition of axon regeneration. Front Mol Neurosci. 9:332016. View Article : Google Scholar : PubMed/NCBI

6 

Harsha KJ and Parameswaran K: Permanent spinal cord injury during lumbar spinal anesthesia: A report of two cases. Neurol India. 64:808–811. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Nunnerley J, Gupta S, Snell D and King M: Training wheelchair navigation in immersive virtual environments for patients with spinal cord injury-end-user input to design an effective system. Disabil Rehabil Assist Technol. 12:417–423. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Sachdeva R, Farrell K, McMullen MK, Twiss JL and Houle JD: Dynamic changes in local protein synthetic machinery in regenerating central nervous system axons after spinal cord injury. Neural Plast. 2016:40872542016. View Article : Google Scholar : PubMed/NCBI

9 

Haik MN, Alburquerque-Sendín F, Moreira RF, Pires ED and Camargo PR: Effectiveness of physical therapy treatment of clearly defined subacromial pain: A systematic review of randomised controlled trials. Br J Sports Med. 50:1124–1134. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Page MJ, Green S, Mrocki MA, Surace SJ, Deitch J, McBain B, Lyttle N and Buchbinder R: Electrotherapy modalities for rotator cuff disease. Cochrane Database Syst Rev CD012225. 2016. View Article : Google Scholar

11 

D'Angelo R, Morreale A, Donadio V, Boriani S, Maraldi N, Plazzi G and Liguori R: Neuropathic pain following spinal cord injury: What we know about mechanisms, assessment and management. Eur Rev Med Pharmacol Sci. 17:3257–3261. 2013.PubMed/NCBI

12 

Braughler JM and Hall ED: Effects of multi-dose methylprednisolone sodium succinate administration on injured cat spinal cord neurofilament degradation and energy metabolism. J Neurosurg. 61:290–295. 1984. View Article : Google Scholar : PubMed/NCBI

13 

Bi X, Lv H, Chen BL, Li X and Wang XQ: Effects of transcutaneous electrical nerve stimulation on pain in patients with spinal cord injury: A randomized controlled trial. J Phys Ther Sci. 27:23–25. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Phillips AA, Matin N, Frias B, Zheng MM, Jia M, West C, Dorrance AM, Laher I and Krassioukov AV: Rigid and remodelled: Cerebrovascular structure and function after experimental high-thoracic spinal cord transection. J Physiol. 594:1677–1688. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Rabchevsky AG, Fugaccia I, Sullivan PG, Blades DA and Scheff SW: Efficacy of methylprednisolone therapy for the injured rat spinal cord. J Neurosci Res. 68:7–18. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Hextrum S and Bennett S: A Critical examination of subgroup analyses: The national acute spinal cord injury studies and beyond. Front Neurol. 9:112018. View Article : Google Scholar : PubMed/NCBI

18 

Abnoosian A and Maguire G: Case report of an interaction of a vagal nerve stimulation system with a microwave current from a body fat analyzer. Ann Clin Psychiatry. 20:229–230. 2008. View Article : Google Scholar : PubMed/NCBI

19 

von Bary C, Mazzitelli D, Voss B, Kübler F, Schmeller ML, Ndrepepa G and Zrenner B: Evaluation of epicardial microwave lesions in the pig model using an electroanatomic mapping system. J Interv Card Electrophysiol. 22:5–11. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Man L, Lv X, Du XD, Yin G, Zhu X, Zhang Y, Soares JC, Yang XN, Chen X and Zhang XY: Cognitive impairments and low BDNF serum levels in first-episode drug-naive patients with schizophrenia. Psychiatry Res. 263:1–6. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Sapkota S and Dixon RA: A network of genetic effects on non-demented cognitive aging: Alzheimer's genetic risk (CLU + CR1 + PICALM) intensifies cognitive aging genetic risk (COMT + BDNF) selectively for APOe4 carriers. J Alzheimers Dis. 62:887–900. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Chen BH, Park JH, Lee TK, Song M, Kim H, Lee JC, Kim YM, Lee CH, Hwang IK, Kang IJ, et al: Melatonin attenuates scopolamine-induced cognitive impairment via protecting against demyelination through BDNF-TrkB signaling in the mouse dentate gyrus. Chem Biol Interact. 285:8–13. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Hanada M, Tsutsumi K, Arima H, Shinjo R, Sugiura Y, Imagama S, Ishiguro N and Matsuyama Y: Evaluation of the effect of tranilast on rats with spinal cord injury. J Neurol Sci. 346:209–215. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Liu YH, Liu GH, Mei JJ and Wang J: The preventive effects of hyperoside on lung cancer in vitro by inducing apoptosis and inhibiting proliferation through caspase-3 and P53 signaling pathway. Biomed Pharmacother. 83:381–391. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li S, Ou Y, Li C, Wei W, Lei L and Zhang Q: Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats. Exp Ther Med 18: 4682-4688, 2019.
APA
Li, S., Ou, Y., Li, C., Wei, W., Lei, L., & Zhang, Q. (2019). Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats. Experimental and Therapeutic Medicine, 18, 4682-4688. https://doi.org/10.3892/etm.2019.8147
MLA
Li, S., Ou, Y., Li, C., Wei, W., Lei, L., Zhang, Q."Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats". Experimental and Therapeutic Medicine 18.6 (2019): 4682-4688.
Chicago
Li, S., Ou, Y., Li, C., Wei, W., Lei, L., Zhang, Q."Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4682-4688. https://doi.org/10.3892/etm.2019.8147
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Ou Y, Li C, Wei W, Lei L and Zhang Q: Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats. Exp Ther Med 18: 4682-4688, 2019.
APA
Li, S., Ou, Y., Li, C., Wei, W., Lei, L., & Zhang, Q. (2019). Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats. Experimental and Therapeutic Medicine, 18, 4682-4688. https://doi.org/10.3892/etm.2019.8147
MLA
Li, S., Ou, Y., Li, C., Wei, W., Lei, L., Zhang, Q."Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats". Experimental and Therapeutic Medicine 18.6 (2019): 4682-4688.
Chicago
Li, S., Ou, Y., Li, C., Wei, W., Lei, L., Zhang, Q."Therapeutic effect of methylprednisolone combined with high frequency electrotherapy on acute spinal cord injury in rats". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4682-4688. https://doi.org/10.3892/etm.2019.8147
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