Effects of hip replacement combined with alendronate sodium on postoperative healing of osteoporotic femoral neck fracture and levels of CTX‑1 and BALP in patients

Ouyang,Xiao; Ding,Yunzhi; Yu,Li; Xin,Feng; Yang,Xiaowei; Sha,Peng; Tong,Songming; Cheng,Qi; Xu,Yi   Qi

doi:10.3892/etm.2019.8158

Effects of hip replacement combined with alendronate sodium on postoperative healing of osteoporotic femoral neck fracture and levels of CTX‑1 and BALP in patients

Authors:
- Xiao Ouyang
- Yunzhi Ding
- Li Yu
- Feng Xin
- Xiaowei Yang
- Peng Sha
- Songming Tong
- Qi Cheng
- Yi Qi Xu
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Affiliations: Department of Orthopedic Surgery, Affiliated Xuzhou Hospital of Jiangsu University, Xuzhou Third Hospital, Xuzhou, Jiangsu 221005, P.R. China
Published online on: November 1, 2019 https://doi.org/10.3892/etm.2019.8158
Pages: 4583-4590
Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study aimed to explore the improvement of hip replacement combined with alendronate sodium on the condition of patients with osteoporotic femoral neck fracture and factors affecting the efficacy of patients. In total, 140 patients with femoral neck fracture from July 2015 to October 2017 in the Affiliated Xuzhou Hospital of Jiangsu University were collected. Of these, 61 patients were treated with hip replacement as the control group and 79 patients were treated with alendronate sodium as the observation group on the basis of the control group. ELISA was used to detect levels of carboxy‑terminal opeptide of type I collagen (CTX‑I) and bone alkaline phosphatase (BALP) in serum of patients before and after treatment. Harris score was used to compare the clinical efficacy of patients after treatment. Changes in the expression of CTX‑I and BALP before and after treatment were compared between the two groups, and the correlation between CTX‑I and BALP levels and Harris score was analyzed. According to the clinical efficacy of patients, the two groups were divided into the significant effect group and poor effect group. Risk factors affecting the efficacy of patients were analyzed, and the ROC of subjects with risk factors was drawn. After treatment, the expression of BALP in serum increased significantly compared with that before treatment, and the expression of CTX‑I decreased significantly. After treatment, the expression of BALP in serum in the observation group was significantly higher than that in the control group (P<0.05). Multivariate analysis revealed that age, time of operation, CTX‑I after treatment and BALP after treatment were independent risk factors affecting the efficacy of patients. In conclusion, hip replacement combined with alendronate sodium can effectively improve the clinical efficacy of patients, and age, time of operation, CTX‑I after treatment and BALP after treatment are found to be independent risk factors affecting the postoperative efficacy of patients.

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