Clinical outcomes of treatment with cage‑shaped demineralized bone plus local bone grafts vs. autogenous iliac crest bone grafts in instrumented single‑level lumbar fusion: A retrospective cohort study

Zhao,Chen‑Guang; Qin,Jie; Wang,Xin; Xu,Gang; Jia,Yong; Guan,Yu‑Cheng; Mou,Xiang; Yuan,Hua

doi:10.3892/etm.2019.8171

Clinical outcomes of treatment with cage‑shaped demineralized bone plus local bone grafts vs. autogenous iliac crest bone grafts in instrumented single‑level lumbar fusion: A retrospective cohort study

Authors:
- Chen‑Guang Zhao
- Jie Qin
- Xin Wang
- Gang Xu
- Yong Jia
- Yu‑Cheng Guan
- Xiang Mou
- Hua Yuan
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Affiliations: Department of Rehabilitation Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Rehabilitation Center, Lintong Sanatorium of The PLA, Xi'an, Shaanxi 710060, P.R. China, Orthopedic Center, General Hospital of Xinjiang Military Region, Urumqi, Xinjiang 830000, P.R. China
Published online on: November 7, 2019 https://doi.org/10.3892/etm.2019.8171
Pages: 393-399

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Abstract

The aim of the present study was to compare the clinical outcomes of cage‑shaped demineralized bone plus local bone grafts (CDBLG) with those of autogenous iliac crest bone grafts (ICBG) implanted for the treatment of single‑level lumbar intervertebral disc degenerative diseases. A total of 69 cases of degenerative spinal disorder treated between January 2011 and December 2013 were retrospectively analyzed. Of these, 44 were treated with CDBLG and 25 with autogenous ICBG. All fusions were instrumented single level. Fusion was assessed after 6, 12 and 24 months by X‑ray and CT scans post‑operatively. Clinical outcomes were determined during follow‑up and assessments included the Oswestry Disability Index, Visual Analogue Scale for back and leg pain and the Short Form‑36 general health survey physical component summary. The results indicated that the overall fusion rate at 24 months post‑operatively was higher in the ICBG group compared with that in the CDBLG group, although not significantly (P>0.05). All other outcome measures were significantly improved in the two groups after the surgery (P<0.05), but no significant differences were observed between the two groups (P>0.05). Blood loss and mean duration of surgery in the CDBLG group were significantly lower compared with those in the ICBG group (P<0.05). In conclusion, CDBLG achieved a similar fusion rate and clinical outcome as ICBG but was associated with significantly reduced blood loss and mean duration of surgery. In conclusion, the present study provided CDBLG bone graft as an alternative option for single‑level fusion.

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