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Article

The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy

  • Authors:
    • Yong‑Xin Hu
    • Ren‑Dong Zheng
    • Yao‑Fu Fan
    • Li Sun
    • Xin Hu
    • Chao Liu
  • View Affiliations / Copyright

    Affiliations: Laboratory of Endocrinology and Metabolism, The Third Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210013, P.R. China, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China
  • Pages: 333-338
    |
    Published online on: November 8, 2019
       https://doi.org/10.3892/etm.2019.8179
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Abstract

The aim of the present study was to analyze the effects of methylprednisolone pulse therapy (MPPT) courses on bone metabolism in patients with Graves' ophthalmopathy (GO). A retrospective analysis of 45 patients with moderate‑to‑severe active GO who received 1 or 2 courses of MPPT was performed. Of these, 16 patients underwent 2 courses of treatment. Bone metabolic markers and the density of the lumbar spine (L1‑4), femoral neck and total hip were measured using a dual‑energy X‑ray bone density instrument, and the differences in bone metabolism prior to and after treatment were determined for each group and compared. The results indicated that serum I collagen N‑terminal peptide (P1NP) and serum β‑collagen crosslinked C‑terminal peptide (CTX) were markedly decreased after the first pulse of treatment. In those patients who received a second course of MPPT, CTX levels were significantly decreased, but P1NP was not significantly different from the baseline value. CTX and P1NP levels remained unchanged between the first and second course of MPPT; similarly, there were no changes from baseline in 25(OH) vitamin D3 and bone mineral density after the first and second course of MPPT. However, the level of 25(OH) vitamin D3 was significantly elevated after the second course compared with the first course. In conclusion, the side effects of MPPT on bone metabolism were marginal and a second course of MPPT did not worsen bone metabolism. These MPPT regimens may therefore be considered to be a safe and effective treatment option for patients with moderate‑to‑severe active GO.
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Copy and paste a formatted citation
Spandidos Publications style
Hu YX, Zheng RD, Fan YF, Sun L, Hu X and Liu C: The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy. Exp Ther Med 19: 333-338, 2020.
APA
Hu, Y., Zheng, R., Fan, Y., Sun, L., Hu, X., & Liu, C. (2020). The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy. Experimental and Therapeutic Medicine, 19, 333-338. https://doi.org/10.3892/etm.2019.8179
MLA
Hu, Y., Zheng, R., Fan, Y., Sun, L., Hu, X., Liu, C."The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy". Experimental and Therapeutic Medicine 19.1 (2020): 333-338.
Chicago
Hu, Y., Zheng, R., Fan, Y., Sun, L., Hu, X., Liu, C."The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy". Experimental and Therapeutic Medicine 19, no. 1 (2020): 333-338. https://doi.org/10.3892/etm.2019.8179
Copy and paste a formatted citation
x
Spandidos Publications style
Hu YX, Zheng RD, Fan YF, Sun L, Hu X and Liu C: The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy. Exp Ther Med 19: 333-338, 2020.
APA
Hu, Y., Zheng, R., Fan, Y., Sun, L., Hu, X., & Liu, C. (2020). The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy. Experimental and Therapeutic Medicine, 19, 333-338. https://doi.org/10.3892/etm.2019.8179
MLA
Hu, Y., Zheng, R., Fan, Y., Sun, L., Hu, X., Liu, C."The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy". Experimental and Therapeutic Medicine 19.1 (2020): 333-338.
Chicago
Hu, Y., Zheng, R., Fan, Y., Sun, L., Hu, X., Liu, C."The effects of bone metabolism in different methylprednisolone pulse treatments for Graves' ophthalmopathy". Experimental and Therapeutic Medicine 19, no. 1 (2020): 333-338. https://doi.org/10.3892/etm.2019.8179
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