Open Access

Bisphenol A‑induced oxidative damage in the hepatic and cardiac tissues of rats: The modulatory role of sesame lignans

  • Authors:
    • Saber M. Eweda
    • Al Sayeda A. Newairy
    • Heba M. Abdou
    • Assmaa S. Gaber
  • View Affiliations

  • Published online on: November 13, 2019     https://doi.org/10.3892/etm.2019.8193
  • Pages: 33-44
  • Copyright: © Eweda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bisphenol A (BPA) is an environmental pollutant that is widely produced throughout the world. It is primarily used in the manufacture of polycarbonate plastics, epoxy resins, paints and dental materials. BPA has been reported to promote hepatotoxicity and cardiotoxicity. The antioxidant activity of sesame lignans is well established. The current study assessed the protective efficiency of sesame lignans against BPA‑induced hepatotoxicity and cardiotoxicity. Rats were divided into 4 groups: A control group, a BPA‑treated group, a sesame lignans‑treated group and a sesame lignans and BPA‑treated group. Rats were orally administered their respective doses daily [30 mg/kg body weight (BW) BPA and/or 20 mg/kg BW sesame lignans] for 6 weeks. Liver function tests were performed using serum of all groups. Lipid profile and antioxidant status were also measured in liver tissue of the studied groups. The results were confirmed by histopathological examination of liver and heart tissues. The oral administration of BPA was revealed to elicit significant decreases in the activities of hepatic glutathione peroxidase, glutathione reductase, superoxide dismutase and glutathione. It also significantly increased levels of malondialdehyde. Furthermore, BPA‑treatment resulted in lipid accumulation, elevated activities of alanine aminotransferase, creatine kinase MB and lactate dehydrogenase, and histological changes of liver and heart tissues. However, the co‑administration of sesame lignans and BPA attenuated hepatotoxicity, cardiotoxicity and BPA‑induced histological changes. The results of the current study indicated that sesame lignans may be helpful in the development of novel natural drugs to treat hepatic and cardiovascular disorders.
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January-2020
Volume 19 Issue 1

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Spandidos Publications style
Eweda SM, Newairy AS, Abdou HM and Gaber AS: Bisphenol A‑induced oxidative damage in the hepatic and cardiac tissues of rats: The modulatory role of sesame lignans. Exp Ther Med 19: 33-44, 2020
APA
Eweda, S.M., Newairy, A.S., Abdou, H.M., & Gaber, A.S. (2020). Bisphenol A‑induced oxidative damage in the hepatic and cardiac tissues of rats: The modulatory role of sesame lignans. Experimental and Therapeutic Medicine, 19, 33-44. https://doi.org/10.3892/etm.2019.8193
MLA
Eweda, S. M., Newairy, A. S., Abdou, H. M., Gaber, A. S."Bisphenol A‑induced oxidative damage in the hepatic and cardiac tissues of rats: The modulatory role of sesame lignans". Experimental and Therapeutic Medicine 19.1 (2020): 33-44.
Chicago
Eweda, S. M., Newairy, A. S., Abdou, H. M., Gaber, A. S."Bisphenol A‑induced oxidative damage in the hepatic and cardiac tissues of rats: The modulatory role of sesame lignans". Experimental and Therapeutic Medicine 19, no. 1 (2020): 33-44. https://doi.org/10.3892/etm.2019.8193