Open Access

Fructus Viticis methanolic extract attenuates trigeminal hyperalgesia in migraine by regulating injury signal transmission

  • Authors:
    • Wen Wen
    • Huan Chen
    • Kun Fu
    • Jiangping Wei
    • Lixia Qin
    • Ting Pan
    • Shijun Xu
  • View Affiliations

  • Published online on: November 15, 2019     https://doi.org/10.3892/etm.2019.8201
  • Pages: 85-94
  • Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Migraine, characterized by hyperalgesia of the trigeminovascular system, is a severe condition that leads to severe reductions in the quality of life. Upon external stimulation, the levels of various neurotransmitters, including aspartic acid (Asp), glutamic acid (Glu), γ‑amino butyric acid (GABA), norepinephrine (NE) and 5‑hydroxytryptamine (5‑HT), are significantly altered; this directly or indirectly promotes trigeminal hypersensitivity. Fructus Viticis is a Traditional Chinese Medicine with analgesic properties to provide efficient relief of migraine. In the present study, the underlying mechanisms of the analgesic effect of Fructus Viticis methanolic extract were assessed in rats with nitroglycerin‑induced migraine. The plasma levels of the neurotransmitters calcitonin gene‑related peptide (CGRP) and substance P (SP), as well as the amount of c‑fos immunoreactive cells (c‑fos IR cells) in the brain, were detected. The analgesic effect was obvious, as Fructus Viticis methanolic extract ameliorated migraine‑like behaviours in nitroglycerin‑induced rats. The levels of 5‑HT, GABA and NE in the brain of migraine model rats was lower compared with that of control rats, whereas opposite observations were made in the contents of excitatory amino acids. Pre‑treatment with Fructus Viticis methanolic extract elevated the levels of 5‑HT, GABA and NE, and also lowered the levels of excitatory amino acids, including Glu and Asp. In addition, treatment with Fructus Viticis methanolic extract lowered the plasma levels of CGRP and SP and decreased the c‑fos IR cells in the brainstem. The present study provided a further scientific basis for the anti‑migraine effects of Fructus Viticis.
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January-2020
Volume 19 Issue 1

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Online ISSN:1792-1015

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Spandidos Publications style
Wen W, Chen H, Fu K, Wei J, Qin L, Pan T and Xu S: Fructus Viticis methanolic extract attenuates trigeminal hyperalgesia in migraine by regulating injury signal transmission. Exp Ther Med 19: 85-94, 2020
APA
Wen, W., Chen, H., Fu, K., Wei, J., Qin, L., Pan, T., & Xu, S. (2020). Fructus Viticis methanolic extract attenuates trigeminal hyperalgesia in migraine by regulating injury signal transmission. Experimental and Therapeutic Medicine, 19, 85-94. https://doi.org/10.3892/etm.2019.8201
MLA
Wen, W., Chen, H., Fu, K., Wei, J., Qin, L., Pan, T., Xu, S."Fructus Viticis methanolic extract attenuates trigeminal hyperalgesia in migraine by regulating injury signal transmission". Experimental and Therapeutic Medicine 19.1 (2020): 85-94.
Chicago
Wen, W., Chen, H., Fu, K., Wei, J., Qin, L., Pan, T., Xu, S."Fructus Viticis methanolic extract attenuates trigeminal hyperalgesia in migraine by regulating injury signal transmission". Experimental and Therapeutic Medicine 19, no. 1 (2020): 85-94. https://doi.org/10.3892/etm.2019.8201