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Article Open Access

Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model

  • Authors:
    • Tieyu Tang
    • Zuowei Duan
    • Jiang Xu
    • Jingyan Liang
    • Shuai Zhang
    • Haifeng Zhang
    • Xinjiang Zhang
    • Yingge Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Department of Neurology, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China, Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 45-52
    |
    Published online on: November 18, 2019
       https://doi.org/10.3892/etm.2019.8211
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Abstract

Endothelial cell injury in vascular arterial walls is a hallmark of atherosclerosis. Pterostilbene (Pts) has been shown to have an anti‑oxidative and anti‑apoptotic effect in numerous diseases via regulation of intracellular metabolism. The purpose of this study was to investigate the protective effect and possible mechanism of Pts against endothelial cell apoptosis in an atherosclerotic rat model. An atherosclerotic rat model was established using a high‑fat, high glucose and high cholesterol diet. The effects of Pts on apoptosis and oxidative stress injury were measured using atherosclerotic lesion analysis, western blot analysis, hematoxylin and eosin straining, TUNEL assay and immunohistochemistry. In vivo results in an atherosclerosis rat model showed that Pts administration decreased the inflammatory response. Pts administration attenuated atherogenesis, reduced aortic plaque size, reduced macrophage infiltration, and suppressed oxidative stress and apoptosis of vascular arterial walls. In vitro assays using cultured human endothelial cells showed that Pts administration decreased hydrogen peroxide‑induced cytotoxicity, oxidative stress injury and apoptosis via nuclear factor erythroid 2‑related factor 2 (Nrf2) activation in endothelial cells. Additionally, Pts administration increased the expression level of Nrf2 and 5' adenosine monophosphate‑activated protein kinase (AMPK), and the phosphorylation level of AMPK and decreased signal transducer and activator of transcription 3 (STAT3) expression in these cells. Furthermore, knockdown of Nrf2 prevented Pts‑decrease oxidative stress injury and apoptosis. In conclusion, these data suggest that Pts can protect endothelial cells in the vascular arterial walls against atherosclerosis‑induced injury through regulation of the Nrf2‑mediated AMPK/STAT3 pathway.
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1 

Okuyama H, Hamazaki T, Hama R, Ogushi Y, Kobayashi T, Ohara N and Uchino H: A critical review of the consensus statement from the European Atherosclerosis Society Consensus Panel 2017. Pharmacology. 101:184–218. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Henrot P, Foret J, Barnetche T, Lazaro E, Duffau P, Seneschal J, Schaeverbeke T, Truchetet ME and Richez C: Assessment of subclinical atherosclerosis in systemic lupus erythematosus: A systematic review and meta-analysis. Joint Bone Spine. 85:155–163. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Martins P, Castela E, Rocha G, Sena C and Seiça R: Premature atherosclerosis in HIV-infected pediatric patients: Literature review and clinical approach. Acta Med Port. 30:742–749. 2017.(In Portuguese). View Article : Google Scholar : PubMed/NCBI

4 

Zhao TX and Mallat Z: Targeting the immune system in atherosclerosis: JACC State-of-the-art review. J Am Coll Cardiol. 73:1691–1706. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Parolin M, Dassie F, Martini C, Mioni R, Russo L, Fallo F, Rossato M, Vettor R, Maffei P and Pagano C: Preclinical markers of atherosclerosis in acromegaly: A systematic review and meta-analysis. Pituitary. 21:653–662. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Song P, Xia W, Zhu Y, Wang M, Chang X, Jin S, Wang J and An L: Prevalence of carotid atherosclerosis and carotid plaque in Chinese adults: A systematic review and meta-regression analysis. Atherosclerosis. 276:67–73. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Stachyra K, Kiepura A and Olszanecki R: Air pollution and atherosclerosis - a brief review of mechanistic links between atherogenesis and biological actions of inorganic part of particulate matter. Folia Med Cracov. 57:37–46. 2017.PubMed/NCBI

8 

Fava C and Montagnana M: Atherosclerosis is an inflammatory disease which lacks a common anti-inflammatory therapy: How human genetics can help to this issue. A narrative review. Front Pharmacol. 9:552018. View Article : Google Scholar : PubMed/NCBI

9 

Hartman J and Frishman WH: Inflammation and atherosclerosis: A review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy. Cardiol Rev. 22:147–151. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Patel TN, Shishehbor MH and Bhatt DL: A review of high-dose statin therapy: Targeting cholesterol and inflammation in atherosclerosis. Eur Heart J. 28:664–672. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Wang W, Ding XQ, Gu TT, Song L, Li JM, Xue QC and Kong LD: Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative stress and inflammation via microRNA-377. Free Radic Biol Med. 83:214–226. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Lv M, Liu K, Fu S, Li Z and Yu X: Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart. Mole Med Rep. 11:724–728. 2015. View Article : Google Scholar

13 

Zhang Y: Pterostilbene, a novel natural plant conduct, inhibits high fat-induced atherosclerosis inflammation via NF-kappaB signaling pathway in Toll-like receptor 5 (TLR5) deficient mice. Biomed Pharmacother. 81:345–355. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Gao D, Jing S, Zhang Q and Wu G: Pterostilbene protects against acute renal ischemia reperfusion injury and inhibits oxidative stress, inducible nitric oxide synthase expression and inflammation in rats via the Toll-like receptor 4/nuclear factor-κB signaling pathway. Exp Ther Med. 15:1029–1035. 2018.PubMed/NCBI

15 

Lin HC, Hsieh MJ, Peng CH, Yang SF and Huang CN: Pterostilbene inhibits vascular smooth muscle cells migration and matrix metalloproteinase-2 through modulation of MAPK pathway. J Food Sci. 80:H2331–H2335. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Park ES, Lim Y, Hong JT, Yoo HS, Lee CK, Pyo MY and Yun YP: Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway. Vascul Pharmacol. 53:61–67. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev AT, Kisielow J, Hersberger M, Yamamoto M, Bachmann MF and Kopf M: Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol. 41:2040–2051. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Sussan TE, Jun J, Thimmulappa R, Bedja D, Antero M, Gabrielson KL, Polotsky VY and Biswal S: Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS One. 3:e37912008. View Article : Google Scholar : PubMed/NCBI

19 

Chernukha IM, Fedulova LV, Kotenkova EA, Takeda S and Sakata R: Hypolipidemic and anti-inflammatory effects of aorta and heart tissues of cattle and pigs in the atherosclerosis rat model. Anim Sci J. 89:784–793. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Chai JT, Biasiolli L, Li L, Alkhalil M, Galassi F, Darby C, Halliday AW, Hands L, Magee T, Perkins J, et al: Quantification of lipid-rich core in carotid atherosclerosis using magnetic resonance T2 mapping: Relation to clinical presentation. JACC Cardiovasc Imaging. 10:747–756. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Bombaca ACS, Viana PG, Santos ACC, Silva TL, Rodrigues ABM, Guimarães ACR, Goulart MOF, da Silva Júnior EN and Menna-Barreto RFS: Mitochondrial disfunction and ROS production are essential for anti-Trypanosoma cruzi activity of beta-lapachone-derived naphthoimidazoles. Free Radical Biol Med. 130:408–418. 2018. View Article : Google Scholar

22 

Kosuru R, Kandula V, Rai U, Prakash S, Xia Z and Singh S: Pterostilbene decreases cardiac oxidative stress and inflammation via activation of AMPK/Nrf2/HO-1 pathway in fructose-fed diabetic rats. Cardiovasc Drugs Ther. 32:147–163. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Elango B, Dornadula S, Paulmurugan R and Ramkumar KM: Pterostilbene ameliorates streptozotocin-induced diabetes through enhancing antioxidant signaling pathways mediated by Nrf2. Chem Res Toxicol. 29:47–57. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Geovanini GR and Libby P: Atherosclerosis and inflammation: Overview and updates. Clin Sci (Lond). 132:1243–1252. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Lin J, Kakkar V and Lu X: Impact of MCP-1 in atherosclerosis. Curr Pharm Des. 20:4580–4588. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Bernberg E, Ulleryd MA, Johansson ME and Bergström GM: Social disruption stress increases IL-6 levels and accelerates atherosclerosis in ApoE−/− mice. Atherosclerosis. 221:359–365. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Grebe A, Hoss F and Latz E: NLRP3 Inflammasome and the IL-1 pathway in atherosclerosis. Circ Res. 122:1722–1740. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Park KY and Heo TH: Critical role of TNF inhibition in combination therapy for elderly mice with atherosclerosis. Cardiovasc Ther. 35:352017. View Article : Google Scholar

29 

Zhou Q, Han X, Li R, Zhao W, Bai B, Yan C and Dong X: Anti-atherosclerosis of oligomeric proanthocyanidins from Rhodiola rosea on rat model via hypolipemic, antioxidant, anti-inflammatory activities together with regulation of endothelial function. Phytomedicine. 51:171–180. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Wu T, Peng Y, Yan S, Li N, Chen Y and Lan T: Andrographolide ameliorates atherosclerosis by suppressing pro-inflammation and ROS generation-mediated foam cell formation. Inflammation. 41:1681–1689. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Décordé K, Ventura E, Lacan D, Ramos J, Cristol JP and Rouanet JM: An SOD rich melon extract Extramel prevents aortic lipids and liver steatosis in diet-induced model of atherosclerosis. Nutr Metab Cardiovasc Dis. 20:301–307. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Yao Y, Liu K, Zhao Y, Hu X and Wang M: Pterostilbene and 4′-Methoxyresveratrol inhibited lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. Molecules. 23:232018. View Article : Google Scholar

33 

Mitra R, O'Neil GL, Harding IC, Cheng MJ, Mensah SA and Ebong EE: Glycocalyx in atherosclerosis-relevant endothelium function and as a therapeutic target. Curr Atheroscler Rep. 19:632017. View Article : Google Scholar : PubMed/NCBI

34 

Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G and Gimbrone MA Jr: Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2. Circ Res. 101:723–733. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Zeng Y, Li C, Guan M, Zheng Z, Li J, Xu W, Wang L, He F and Xue Y: The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms. Cardiovasc Diabetol. 13:322014. View Article : Google Scholar : PubMed/NCBI

36 

Fullerton MD, Steinberg GR and Schertzer JD: Immunometabolism of AMPK in insuliresistance and atherosclerosis. Mol Cell Endocrinol. 366:224–234. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, et al: AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 13:376–388. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Vasamsetti SB, Karnewar S, Kanugula AK, Thatipalli AR, Kumar JM and Kotamraju S: Metformin inhibits monocyte-to-macrophage differentiation via AMPK-mediated inhibition of STAT3 activation: Potential role in atherosclerosis. Diabetes. 64:2028–2041. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang T, Duan Z, Xu J, Liang J, Zhang S, Zhang H, Zhang X and Wang Y: Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model. Exp Ther Med 19: 45-52, 2020.
APA
Tang, T., Duan, Z., Xu, J., Liang, J., Zhang, S., Zhang, H. ... Wang, Y. (2020). Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model. Experimental and Therapeutic Medicine, 19, 45-52. https://doi.org/10.3892/etm.2019.8211
MLA
Tang, T., Duan, Z., Xu, J., Liang, J., Zhang, S., Zhang, H., Zhang, X., Wang, Y."Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model". Experimental and Therapeutic Medicine 19.1 (2020): 45-52.
Chicago
Tang, T., Duan, Z., Xu, J., Liang, J., Zhang, S., Zhang, H., Zhang, X., Wang, Y."Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model". Experimental and Therapeutic Medicine 19, no. 1 (2020): 45-52. https://doi.org/10.3892/etm.2019.8211
Copy and paste a formatted citation
x
Spandidos Publications style
Tang T, Duan Z, Xu J, Liang J, Zhang S, Zhang H, Zhang X and Wang Y: Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model. Exp Ther Med 19: 45-52, 2020.
APA
Tang, T., Duan, Z., Xu, J., Liang, J., Zhang, S., Zhang, H. ... Wang, Y. (2020). Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model. Experimental and Therapeutic Medicine, 19, 45-52. https://doi.org/10.3892/etm.2019.8211
MLA
Tang, T., Duan, Z., Xu, J., Liang, J., Zhang, S., Zhang, H., Zhang, X., Wang, Y."Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model". Experimental and Therapeutic Medicine 19.1 (2020): 45-52.
Chicago
Tang, T., Duan, Z., Xu, J., Liang, J., Zhang, S., Zhang, H., Zhang, X., Wang, Y."Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2‑mediated AMPK/STAT3 pathway in an atherosclerosis rat model". Experimental and Therapeutic Medicine 19, no. 1 (2020): 45-52. https://doi.org/10.3892/etm.2019.8211
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