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Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage

  • Authors:
    • Zhenli Cai
    • Haidong Zhang
    • Hongshan Song
    • Ying Piao
    • Xiaoye Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Daqinglongnan Hospital, Daqing, Heilongjiang 163453, P.R. China, Department of Oncology, Daqing People's Hospital, Daqing, Heilongjiang 163000, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 646-650
    |
    Published online on: November 25, 2019
       https://doi.org/10.3892/etm.2019.8240
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Abstract

Effects of edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage were investigated. Eighty SD rats were selected to establish subarachnoid hemorrhage (SAH) rat models, which were divided into sham operation group, SAH group, MCI group and combined group. Hippocampal tissue of each group was taken to observe the number of neurocytes. The expression levels of Beclin-1 and (light chain LC3)-II of rats in each group were detected by ELISA. Pearson's correlation factors were used to analyze the correlation between Beclin-1 and LC3-11, and neurological function tests were carried out on rats of each group 14 and 28 days after administration. The morphological and structural damage of nerve cells in the combined group was further alleviated, and the survival rate of neurons significantly increased at all time points (P<0.05). The expression levels of Beclin-1 and LC3-11 in combined group was significantly higher than those in SAH group and CMI group (P<0.05), and Beclin-1 was positively correlated with LC3-11 (r=0.9454). Longa score of the combined group was significantly lower than that of the other two groups, and muscle strength score was significantly higher than that of the other two groups (P<0.05). Edaravone combined with cinepazide maleate can effectively increase the survival rate of brain cells and promote the volatilization of neurological function in the treatment of hemorrhage in the subretinal space of the omentum, which is worthy of popularization and application.
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Copy and paste a formatted citation
Spandidos Publications style
Cai Z, Zhang H, Song H, Piao Y and Zhang X: Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage. Exp Ther Med 19: 646-650, 2020.
APA
Cai, Z., Zhang, H., Song, H., Piao, Y., & Zhang, X. (2020). Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage. Experimental and Therapeutic Medicine, 19, 646-650. https://doi.org/10.3892/etm.2019.8240
MLA
Cai, Z., Zhang, H., Song, H., Piao, Y., Zhang, X."Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage". Experimental and Therapeutic Medicine 19.1 (2020): 646-650.
Chicago
Cai, Z., Zhang, H., Song, H., Piao, Y., Zhang, X."Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage". Experimental and Therapeutic Medicine 19, no. 1 (2020): 646-650. https://doi.org/10.3892/etm.2019.8240
Copy and paste a formatted citation
x
Spandidos Publications style
Cai Z, Zhang H, Song H, Piao Y and Zhang X: Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage. Exp Ther Med 19: 646-650, 2020.
APA
Cai, Z., Zhang, H., Song, H., Piao, Y., & Zhang, X. (2020). Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage. Experimental and Therapeutic Medicine, 19, 646-650. https://doi.org/10.3892/etm.2019.8240
MLA
Cai, Z., Zhang, H., Song, H., Piao, Y., Zhang, X."Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage". Experimental and Therapeutic Medicine 19.1 (2020): 646-650.
Chicago
Cai, Z., Zhang, H., Song, H., Piao, Y., Zhang, X."Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage". Experimental and Therapeutic Medicine 19, no. 1 (2020): 646-650. https://doi.org/10.3892/etm.2019.8240
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