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Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients

  • Authors:
    • Xueling Wang
    • Juanjuan Liu
    • Dongqing Wang
    • Honghua Zhu
    • Le Kang
    • Juan Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Obstetrics, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China, Department of Obstetrics (Maternal and Child Health Center), The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Gastroenterology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Obstetrics, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Nursing, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 710-716
    |
    Published online on: November 26, 2019
       https://doi.org/10.3892/etm.2019.8247
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Abstract

Expression and correlation of Chemerin and fatty acid‑binding protein 4 (FABP4) in peripheral blood of gestational diabetes mellitus (GDM) patients were investigated. Sixty patients with GDM from March 2018 to March 2019 in the People's Hospital of Zhangqiu Area were selected as the study group (SG) and another 50 healthy pregnant women corresponding to their age and pregnancy were selected as the control group (CG). Enzyme linked immunosorbent assay (ELISA) was used to detect the expression of Chemerin and FABP4 in serum. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of Chemerin and FABP4 in peripheral blood for GDM patients. Pearson's correlation coefficient was used to analyze the correlation between Chemerin and FABP4 and the correlation between Chemerin and inflammatory factors such as interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α). Expression of Chemerin and FABP4 in peripheral blood of GDM patients were significantly higher than those in CG. The AUC of GDM patients diagnosed with Chemerin and FABP4 in peripheral blood was 0.820 and 0.814, while the AUC of GDM patients diagnosed with Chemerin combined with FABP4 in peripheral blood was 0.904. Expression of inflammatory factors IL‑6 and TNF‑α in the SG were significantly higher than those in the CG. Chemerin in the SG was positively correlated with FABP4 and positively correlated with inflammatory factors IL‑6 and TNF‑α. Patients with advanced age (≥35 years), family history of diabetes, hyperlipidemia, high pre‑pregnancy BMI, high fasting blood glucose, high Chemerin and high FABP4 expression have high risk of GDM. In conclusion, Chemerin and FABP4 were upregulated in the peripheral blood of GDM patients. There was a positive correlation between the two and a positive correlation with the inflammatory factors IL‑6 and TNF‑α.
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1 

Vokalova L, van Breda SV, Ye XL, Huhn EA, Than NG, Hasler P, Lapaire O, Hoesli I, Rossi SW and Hahn S: Excessive neutrophil activity in gestational diabetes mellitus: Could it contribute to the development of preeclampsia? Front Endocrinol (Lausanne). 9:5422018. View Article : Google Scholar : PubMed/NCBI

2 

Schaefer-Graf U, Napoli A and Nolan CJ; Diabetic Pregnancy Study Group, : Diabetes in pregnancy: A new decade of challenges ahead. Diabetologia. 61:1012–1021. 2018.PubMed/NCBI

3 

Damm P, Houshmand-Oeregaard A, Kelstrup L, Lauenborg J, Mathiesen ER and Clausen TD: Gestational diabetes mellitus and long-term consequences for mother and offspring: A view from Denmark. Diabetologia. 59:1396–1399. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Sweeting AN, Ross GP, Hyett J, Molyneaux L, Constantino M, Harding AJ and Wong J: Gestational diabetes mellitus in early pregnancy: Evidence for poor pregnancy outcomes despite treatment. Diabetes Care. 39:75–81. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Pantham P, Aye IL and Powell TL: Inflammation in maternal obesity and gestational diabetes mellitus. Placenta. 36:709–715. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Powe CE, Allard C, Battista MC, Doyon M, Bouchard L, Ecker JL, Perron P, Florez JC, Thadhani R and Hivert MF: Heterogeneous contribution of insulin sensitivity and secretion defects to gestational diabetes mellitus. Diabetes Care. 39:1052–1055. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Du J, Zhu YL and Gao XM: Expressions of inflammatory cytokines and fat factors in placentas of patients with gestational diabetes mellitus and their relationship with glucose and lipid metabolism. Hainan Yixueyuan Xuebao. 22:39–42. 2016.(In Chinese).

8 

Mariani F and Roncucci L: Chemerin/chemR23 axis in inflammation onset and resolution. Inflamm Res. 64:85–95. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Kennedy AJ and Davenport AP: International union of basic and clinical pharmacology CIII: Chemerin receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) nomenclature, pharmacology, and function. Pharmacol Rev. 70:174–196. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Haberl EM, Pohl R, Rein-Fischboeck L, Feder S, Eisinger K, Krautbauer S, Sinal CJ and Buechler C: Ex vivo analysis of serum chemerin activity in murine models of obesity. Cytokine. 104:42–45. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Cetin O, Kurdoglu Z, Kurdoglu M and Sahin HG: Chemerin level in pregnancies complicated by preeclampsia and its relation with disease severity and neonatal outcomes. J Obstet Gynaecol. 37:195–199. 2017.PubMed/NCBI

12 

Yang X, Quan X, Lan Y, Wei Q, Ye J, Yin X, Ji Z, Xing H and Yang Y: Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion. Gynecol Endocrinol. 34:864–867. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Ademoglu E, Berberoglu Z, Dellal FD and Ariel KM: Higher levels of circulating chemerin in obese women with gestational diabetes mellitus. Acta Endocrinol (Bucur). 11:1841–0987. 2015.

14 

Yang X, Quan X, Lan Y, Ye J, Wei Q, Yin X, Fan F and Xing H: Serum chemerin level during the first trimester of pregnancy and the risk of gestational diabetes mellitus. Gynecol Endocrinol. 33:770–773. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Guaita-Esteruelas S, Gumà J, Masana L and Borràs J: The peritumoural adipose tissue microenvironment and cancer. The roles of fatty acid binding protein 4 and fatty acid binding protein 5. Mol Cell Endocrinol. 462:107–118. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Hertzel AV, Xu H, Downey M, Kvalheim N and Bernlohr DA: Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling. J Lipid Res. 58:1354–1361. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Ning H, Tao H, Weng Z and Zhao X: Plasma fatty acid-binding protein 4 (FABP4) as a novel biomarker to predict gestational diabetes mellitus. Acta Diabetol. 53:891–898. 2016. View Article : Google Scholar : PubMed/NCBI

18 

de Gennaro G, Palla G, Battini L, Simoncini T, Del Prato S, Bertolotto A and Bianchi C: The role of adipokines in the pathogenesis of gestational diabetes mellitus. Gynecol Endocrinol. 35:737–751. 2019. View Article : Google Scholar : PubMed/NCBI

19 

American Diabetes Association: Classification and diagnosis of diabetes. Diabetes Care. 40 (Suppl 1):S11–S24. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Chang L, Rissin DM, Fournier DR, Piech T, Patel PP, Wilson DH and Duffy DC: Single molecule enzyme-linked immunosorbent assays: theoretical considerations. J Immunol Methods. 378:102–115. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Chen Z, Gong L, Zhang P, Li Y, Liu B, Zhang L, Zhuang J and Xiao D: Epigenetic down-regulation of Sirt 1 via DNA methylation and oxidative stress signaling contributes to the gestational diabetes mellitus-induced fetal programming of heart ischemia-sensitive phenotype in late life. Int J Biol Sci. 15:1240–1251. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Muller PS and Nirmala M: Effects of pre pregnancy maternal body mass index on gestational diabetes mellitus. IACSIT Int J Eng Technol. 7:279–282. 2018. View Article : Google Scholar

23 

Gilbert L, Gross J, Lanzi S, Quansah DY, Puder J and Horsch A: How diet, physical activity and psychosocial well-being interact in women with gestational diabetes mellitus: An integrative review. BMC Pregnancy Childbirth. 19:602019. View Article : Google Scholar : PubMed/NCBI

24 

Artal R, Catanzaro RB, Gavard JA, Mostello DJ and Friganza JC: A lifestyle intervention of weight-gain restriction: diet and exercise in obese women with gestational diabetes mellitus. Appl Physiol Nutr Metab. 32:596–601. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Roca-Rodríguez MM, López-Tinoco C, Fernández-Deudero A, Murri M, García-Palacios MV, García-Valero MA, Tinahones-Madueño FJ and Aguilar-Diosdado M: Adipokines and metabolic syndrome risk factors in women with previous gestational diabetes mellitus. Diabetes Metab Res Rev. 28:542–548. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Zhang J, Chi H, Xiao H, Tian X, Wang Y, Yun X and Xu Y: Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) single nucleotide polymorphisms (SNPs), inflammation and metabolism in gestational diabetes mellitus in Inner Mongolia. Med Sci Monit. 23:4149–4157. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Melekoglu R, Ciftci O, Celik E, Yilmaz E and Bastemur AG: Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-α levels in patients with gestational diabetes mellitus. J Obstet Gynaecol Res. 45:824–829. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Feng Y, Jiang CD, Chang AM, Shi Y, Gao J, Zhu L and Zhang Z: Interactions among insulin resistance, inflammation factors, obesity-related gene polymorphisms, environmental risk factors, and diet in the development of gestational diabetes mellitus. J Matern Fetal Neonatal Med. 32:339–347. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Chung JY, Ain QU, Song Y, Yong SB and Kim YH: Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance. Genome Res. 29:1442–1452. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Josephrajan A, Hertzel AV, Bohm EK, McBurney MW, Imai SI, Mashek DG, Kim DH and Bernlohr DA: Unconventional secretion of adipocyte fatty acid binding protein (FABP4) by adipocytes. FASEB J. 32:814.11. 2018.

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Liu J, Wang D, Zhu H, Kang L and Jiang J: Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients. Exp Ther Med 19: 710-716, 2020.
APA
Wang, X., Liu, J., Wang, D., Zhu, H., Kang, L., & Jiang, J. (2020). Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients. Experimental and Therapeutic Medicine, 19, 710-716. https://doi.org/10.3892/etm.2019.8247
MLA
Wang, X., Liu, J., Wang, D., Zhu, H., Kang, L., Jiang, J."Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients". Experimental and Therapeutic Medicine 19.1 (2020): 710-716.
Chicago
Wang, X., Liu, J., Wang, D., Zhu, H., Kang, L., Jiang, J."Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients". Experimental and Therapeutic Medicine 19, no. 1 (2020): 710-716. https://doi.org/10.3892/etm.2019.8247
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Liu J, Wang D, Zhu H, Kang L and Jiang J: Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients. Exp Ther Med 19: 710-716, 2020.
APA
Wang, X., Liu, J., Wang, D., Zhu, H., Kang, L., & Jiang, J. (2020). Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients. Experimental and Therapeutic Medicine, 19, 710-716. https://doi.org/10.3892/etm.2019.8247
MLA
Wang, X., Liu, J., Wang, D., Zhu, H., Kang, L., Jiang, J."Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients". Experimental and Therapeutic Medicine 19.1 (2020): 710-716.
Chicago
Wang, X., Liu, J., Wang, D., Zhu, H., Kang, L., Jiang, J."Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients". Experimental and Therapeutic Medicine 19, no. 1 (2020): 710-716. https://doi.org/10.3892/etm.2019.8247
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