Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients

Wang,Xueling; Liu,Juanjuan; Wang,Dongqing; Zhu,Honghua; Kang,Le; Jiang,Juan

doi:10.3892/etm.2019.8247

Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients

Authors:
- Xueling Wang
- Juanjuan Liu
- Dongqing Wang
- Honghua Zhu
- Le Kang
- Juan Jiang
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Affiliations: Department of Obstetrics and Gynecology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Obstetrics, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China, Department of Obstetrics (Maternal and Child Health Center), The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Gastroenterology, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Obstetrics, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China, Department of Nursing, The Third People's Hospital of Qingdao, Qingdao, Shandong 266041, P.R. China
Published online on: November 26, 2019 https://doi.org/10.3892/etm.2019.8247
Pages: 710-716
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Expression and correlation of Chemerin and fatty acid‑binding protein 4 (FABP4) in peripheral blood of gestational diabetes mellitus (GDM) patients were investigated. Sixty patients with GDM from March 2018 to March 2019 in the People's Hospital of Zhangqiu Area were selected as the study group (SG) and another 50 healthy pregnant women corresponding to their age and pregnancy were selected as the control group (CG). Enzyme linked immunosorbent assay (ELISA) was used to detect the expression of Chemerin and FABP4 in serum. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of Chemerin and FABP4 in peripheral blood for GDM patients. Pearson's correlation coefficient was used to analyze the correlation between Chemerin and FABP4 and the correlation between Chemerin and inflammatory factors such as interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α). Expression of Chemerin and FABP4 in peripheral blood of GDM patients were significantly higher than those in CG. The AUC of GDM patients diagnosed with Chemerin and FABP4 in peripheral blood was 0.820 and 0.814, while the AUC of GDM patients diagnosed with Chemerin combined with FABP4 in peripheral blood was 0.904. Expression of inflammatory factors IL‑6 and TNF‑α in the SG were significantly higher than those in the CG. Chemerin in the SG was positively correlated with FABP4 and positively correlated with inflammatory factors IL‑6 and TNF‑α. Patients with advanced age (≥35 years), family history of diabetes, hyperlipidemia, high pre‑pregnancy BMI, high fasting blood glucose, high Chemerin and high FABP4 expression have high risk of GDM. In conclusion, Chemerin and FABP4 were upregulated in the peripheral blood of GDM patients. There was a positive correlation between the two and a positive correlation with the inflammatory factors IL‑6 and TNF‑α.

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