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Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance

  • Authors:
    • Bin Wan
    • Xuexia Pan
    • Jinshuai Ma
    • Yao Luo
    • Junyan Liu
    • Guoying Zhao
  • View Affiliations / Copyright

    Affiliations: NICU, Binzhou Medical University Hospital, Binzhou, Shandong 256000, P.R. China, Department of Pediatric, Binzhou People's Hospital, Binzhou, Shandong 256610, P.R. China
    Copyright: © Wan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 545-550
    |
    Published online on: November 26, 2019
       https://doi.org/10.3892/etm.2019.8248
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Abstract

Associations of serum S‑100β, cystatin C (Cys‑C) and C‑reactive protein (CRP) with umbilical cord blood troponin I (TnI), myoglobin (Mb) and creatine kinase‑MB (CK‑MB) in neonatal hypoxic ischemic encephalopathy (NHIE) and the clinical significance were explored. A total of 40 patients with NHIE treated in the Binzhou Medical University Hospital were selected as observation group, while another 40 healthy neonates in the same period were selected as control group. The related data of all subjects were collected, and the levels of serum S‑100β protein, CRP and Cys‑C, and umbilical cord blood TnI, Mb and CK‑MB were compared between the two groups. Associations of the neonatal behavioral neurological assessment (NBNA) score with the changes in serum S‑100β protein, CRP and Cys‑C and umbilical cord blood TnI, Mb and CK‑MB were analyzed. The univariate and multivariate logistic regression analyses were performed to determine the risk factors for NHIE. In observation group, the levels of serum S‑100β protein, CRP and Cys‑C were significantly higher than those in control group, and the levels of umbilical cord blood TnI, Mb and CK‑MB were also significantly higher than those in control group. The NBNA score was negatively correlated with the changes in serum S‑100β protein, CRP and Cys‑C as well as the umbilical cord blood TnI, Mb and CK‑MB. The levels of serum S‑100β protein, CRP and Cys‑C, and umbilical cord blood TnI, Mb and CK‑MB were related risk factors for NHIE. The increased levels of serum S‑100β protein, CRP and Cys‑C, and umbilical cord blood TnI, Mb and CK‑MB were independent risk factors for NHIE. In NHIE patients, the levels of serum S‑100β protein, CRP and Cys‑C, and umbilical cord blood TnI, Mb and CK‑MB all significantly increased, and they have negative correlation with the nervous system function after onset.
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1 

Maggiotto LV, Sondhi M, Shin BC, Garg M and Devaskar SU: Circulating blood cellular glucose transporters - Surrogate biomarkers for neonatal hypoxic-ischemic encephalopathy assessed by novel scoring systems. Mol Genet Metab. 127:166–173. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Chen HM, Gao LX, Wang JJ and Gao C: The correlation between AGT gene polymorphism and neonatal hypoxic-ischemic encephalopathy (HIE). Eur Rev Med Pharmacol Sci. 23:2194–2199. 2019.PubMed/NCBI

3 

Davies A, Wassink G, Bennet L, Gunn AJ and Davidson JO: Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy? Neural Regen Res. 14:1678–1683. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Enweronu-Laryea C, Martinello KA, Rose M, Manu S, Tann CJ, Meek J, Ahor-Essel K, Boylan GB and Robertson NJ: Core temperature after birth in babies with neonatal encephalopathy in a sub-Saharan African hospital setting. J Physiol. 597:4013–4024. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Chin EM, Jayakumar S, Ramos E, Gerner G, Soares BP, Cristofalo E, Leppert M, Allen M, Parkinson C, Johnston M, et al: Preschool language outcomes following perinatal hypoxic-ischemic encephalopathy in the age of therapeutic hypothermia. Dev Neurosci. Jun 5–2019.(Epub ahead of print). doi: 10.1159/000499562. PubMed/NCBI

6 

Kovacs K, Szakmar E, Meder U, Szakacs L, Cseko A, Vatai B, Szabo AJ, McNamara PJ, Szabo M and Jermendy A: A randomized controlled study of low-dose hydrocortisone versus placebo in dopamine-treated hypotensive neonates undergoing hypothermia treatment for hypoxic-ischemic encephalopathy. J Pediatr. 211:13–19.e3. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Wang M, Liu C, Li X, Liu H, Jin C, Tao X, Wang X, Zhao H, Cheng Y, Wu F, et al: Isolated periventricular pseudocysts do not affect white matter microstructure development in neonatal stage: A retrospective case-control diffusion tensor imaging study. Eur J Radiol. 116:152–159. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Yang XL, Wang X, Shao L, Jiang GT, Min JW, Mei XY, He XH, Liu WH, Huang WX and Peng BW: TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI). J Neuroinflammation. 16:1142019. View Article : Google Scholar : PubMed/NCBI

9 

Kim YE, Sung SI, Chang YS, Ahn SY, Sung DK and Park WS: Thrombin preconditioning enhances therapeutic efficacy of human Wharton's Jelly-derived mesenchymal stem cells in severe neonatal hypoxic ischemic encephalopathy. Int J Mol Sci. 20:24772019. View Article : Google Scholar

10 

Jiang F, Yang M, Wu C and Wang J: Potential roles of miR-374a-5p in mediating neuroprotective effects and related molecular mechanism. J Mol Neurosci. 69:123–132. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Scheidegger S, Held U, Grass B, Latal B, Hagmann C and Brotschi B; National Asphyxia and Cooling Register Group, : Association of perinatal risk factors with neurological outcome in neonates with hypoxic ischemic encephalopathy. J Matern Fetal Neonatal Med. Jun 4–2019.(Epub ahead of print). doi: 10.1080/14767058.2019.1623196. View Article : Google Scholar : PubMed/NCBI

12 

Sakhuja P, More K, Ting JY, Sheth J, Lapointe A, Jain A, McNamara PJ and Moore AM: Gastrointestinal hemodynamic changes during therapeutic hypothermia and after rewarming in neonatal hypoxic-ischemic encephalopathy. Pediatr Neonatol. Apr 16–2019.(Epub ahead of print). doi: 10.1016/j.pedneo.2019.04.003. View Article : Google Scholar : PubMed/NCBI

13 

Cánovas-Ahedo M and Alonso-Alconada D: Combined therapy in neonatal hypoxic-ischaemic encephalopathy. An Pediatr (Barc). 91:59.e1–59.e7. 2019.(In Spanish). View Article : Google Scholar

14 

O'Brien CE, Santos PT, Kulikowicz E, Reyes M, Koehler RC, Martin LJ and Lee JK: Hypoxia-ischemia and hypothermia independently and interactively affect neuronal pathology in neonatal piglets with short-term recovery. Dev Neurosci. 41:17–33. 2019. View Article : Google Scholar : PubMed/NCBI

15 

Tani N, Ikeda T, Shida A, Aoki Y, Oritani S and Ishikawa T: Postmortem water contents of major organs with regard to the cause of death. J Forensic Leg Med. 65:48–54. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Chu X, Cao L, Yu Z, Xin D, Li T, Ma W, Zhou X, Chen W, Liu D and Wang Z: Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation. J Neuroinflammation. 16:1042019. View Article : Google Scholar : PubMed/NCBI

17 

Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, Zhuang C, Sun T, Li Y and Yu J: Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway. Life Sci. May 15–2019.(Epub ahead of print). doi: 10.1016/j.lfs.2019.04.070.

18 

Zou L, Yuan H, Liu Q, Lu C and Wang L: Potential protective effects of bilirubin following the treatment of neonatal hypoxic-ischemic encephalopathy with hypothermia therapy. Biosci Rep. Jun 4–2019.(Epub ahead of print). doi: 10.1042/BSR20182332.

19 

Ciobanou A, Jabak S, De Castro H, Frei L, Akolekar R and Nicolaides KH: Biomarkers of impaired placentation at 35–37 weeks' gestation in the prediction of adverse perinatal outcome. Ultrasound Obstet Gynecol. 54:79–86. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Arriagada S, Huang H, Fletcher K and Giannone P: Prevention of excessive hypothermia in infants with hypoxic ischemic encephalopathy prior to admission to a quaternary care center: A neonatal outreach educational project. J Perinatol. 39:1417–1427. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wan B, Pan X, Ma J, Luo Y, Liu J and Zhao G: Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance . Exp Ther Med 19: 545-550, 2020.
APA
Wan, B., Pan, X., Ma, J., Luo, Y., Liu, J., & Zhao, G. (2020). Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance . Experimental and Therapeutic Medicine, 19, 545-550. https://doi.org/10.3892/etm.2019.8248
MLA
Wan, B., Pan, X., Ma, J., Luo, Y., Liu, J., Zhao, G."Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance ". Experimental and Therapeutic Medicine 19.1 (2020): 545-550.
Chicago
Wan, B., Pan, X., Ma, J., Luo, Y., Liu, J., Zhao, G."Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance ". Experimental and Therapeutic Medicine 19, no. 1 (2020): 545-550. https://doi.org/10.3892/etm.2019.8248
Copy and paste a formatted citation
x
Spandidos Publications style
Wan B, Pan X, Ma J, Luo Y, Liu J and Zhao G: Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance . Exp Ther Med 19: 545-550, 2020.
APA
Wan, B., Pan, X., Ma, J., Luo, Y., Liu, J., & Zhao, G. (2020). Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance . Experimental and Therapeutic Medicine, 19, 545-550. https://doi.org/10.3892/etm.2019.8248
MLA
Wan, B., Pan, X., Ma, J., Luo, Y., Liu, J., Zhao, G."Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance ". Experimental and Therapeutic Medicine 19.1 (2020): 545-550.
Chicago
Wan, B., Pan, X., Ma, J., Luo, Y., Liu, J., Zhao, G."Umbilical cord blood troponin I, myoglobin and CK‑MB in neonatal hypoxic ischemic encephalopathy and the clinical significance ". Experimental and Therapeutic Medicine 19, no. 1 (2020): 545-550. https://doi.org/10.3892/etm.2019.8248
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