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Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile

  • Authors:
    • Jian Lyu
    • Yanming Xie
    • Menghua Sun
    • Cheng Zhang
    • Lianxin Wang
  • View Affiliations / Copyright

    Affiliations: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China
    Copyright: © Lyu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 683-695
    |
    Published online on: November 27, 2019
       https://doi.org/10.3892/etm.2019.8252
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Abstract

Numerous clinical studies have evaluated the performance of Sanjin tablets (SJTs) in the treatment of acute lower urinary tract infections (ALUTIs) in China. The present meta‑analysis aimed to determine the efficacy and safety of SJT combined with antibiotics for the treatment of patients with ALUTIs and to evaluate the quality of evidence. The Cochrane Library, PubMed, EMBASE, Web of Science, Chinese BioMedical Database, China National Knowledge Infrastructure, WanFang and VIP databases were searched for entries added between inception and December 2018 to identify relevant randomized controlled trials (RCTs). The Cochrane risk‑of‑bias tool and Consolidated Standards of Reporting Trials for Traditional Chinese Medicine were used for assessing the methodological quality and reporting quality of eligible studies, respectively. Meta‑analysis and quality of evidence assessment were performed with RevMan 5.3 and Grading of Recommendations, Assessment, Development and Evaluations (GRADE), respectively. A total of 8 RCTs comprising 790 patients with ALUTIs were included in the present meta‑analysis. The cure rate of SJTs combined with gatifloxacin tablets (GTs) was higher than that of GTs alone [relative ratio (RR)=1.30, 95% CI=1.07‑1.57, P=0.009]. The cure rate of SJTs combined with levofloxacin tablets (LTs) was higher than that of LTs alone (RR=1.13, 95% CI=1.04‑1.24, P=0.006). SJTs combined with LTs was better in improving the total effective rate than LTs alone (RR=1.11, 95% CI=1.03‑1.19, P=0.005). The recurrence rate for SJTs combined with antibiotics was lower than that associated with antibiotics alone (RR=0.35, 95% CI=0.13‑0.97, P=0.04). The bacterial clearance rate achieved with SJTs combined with antibiotics was higher than that obtained with antibiotics alone (RR=1.41, 95% CI=1.09‑1.84, P=0.009). The present meta‑analysis demonstrated that, compared with the effects of antibiotics treatment, SJTs combined with antibiotics improved the cure rate, total effective rate and bacterial clearance rate, and decreased the recurrence rate. In addition, no serious adverse reactions were observed in patients with ALUTIs. However, the GRADE quality of evidence was low. Thus, further large‑scale and rigorously designed clinical trials are required to improve the quality of evidence.
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Copy and paste a formatted citation
Spandidos Publications style
Lyu J, Xie Y, Sun M, Zhang C and Wang L: Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile. Exp Ther Med 19: 683-695, 2020.
APA
Lyu, J., Xie, Y., Sun, M., Zhang, C., & Wang, L. (2020). Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile. Experimental and Therapeutic Medicine, 19, 683-695. https://doi.org/10.3892/etm.2019.8252
MLA
Lyu, J., Xie, Y., Sun, M., Zhang, C., Wang, L."Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile". Experimental and Therapeutic Medicine 19.1 (2020): 683-695.
Chicago
Lyu, J., Xie, Y., Sun, M., Zhang, C., Wang, L."Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile". Experimental and Therapeutic Medicine 19, no. 1 (2020): 683-695. https://doi.org/10.3892/etm.2019.8252
Copy and paste a formatted citation
x
Spandidos Publications style
Lyu J, Xie Y, Sun M, Zhang C and Wang L: Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile. Exp Ther Med 19: 683-695, 2020.
APA
Lyu, J., Xie, Y., Sun, M., Zhang, C., & Wang, L. (2020). Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile. Experimental and Therapeutic Medicine, 19, 683-695. https://doi.org/10.3892/etm.2019.8252
MLA
Lyu, J., Xie, Y., Sun, M., Zhang, C., Wang, L."Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile". Experimental and Therapeutic Medicine 19.1 (2020): 683-695.
Chicago
Lyu, J., Xie, Y., Sun, M., Zhang, C., Wang, L."Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta‑analysis and GRADE evidence profile". Experimental and Therapeutic Medicine 19, no. 1 (2020): 683-695. https://doi.org/10.3892/etm.2019.8252
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