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Article Open Access

Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience

  • Authors:
    • Chen‑Guang Jia
    • Jian‑Guo Gao
    • Feng‑Sheng Liu
    • Zhuo Li
    • Zhao‑Liang Dong
    • Li‑Ming Yao
    • Lian‑Bo Wang
    • Xiao‑Wei Yao
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The Chest Hospital of Hebei Province, Shijiazhuang, Hebei 050041, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 519-526
    |
    Published online on: November 27, 2019
       https://doi.org/10.3892/etm.2019.8253
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Abstract

The present study aimed to retrospectively analyze the safety and efficacy of the early surgical management of thoracic tuberculosis (TB) in patients with neurological deficits. The medical data of patients with thoracic TB exhibiting neurological deficit in the Chest Hospital of Hebei Province were retrospectively reviewed. A total of 234 cases, including 123 males and 115 females, were recruited in the present study. Their pre‑ and postoperative neurological deficit and pain levels were assessed using the 2002 American spinal injury association (ASIA) impairment scale and visual analog scale, respectively. Patients were divided into two groups according to whether their preoperative standardized anti‑TB treatment time was ≥4 weeks or <4 weeks. There was no difference in blood loss and operation time between the two groups. The erythrocyte sedimentation rate was higher in patients receiving standard anti‑TB <4 weeks prior to and 1 month following surgery compared with the ≥4 weeks group, but the difference was not significant 6 months following surgery. ASIA scale scores all increased significantly 1 month following surgery in the <4 weeks group compared with the ≥4 weeks group (P=0.001) though there was no difference between the scores prior to surgery. ASIA scale scores improved to 4.4±0.5 and 4.5±0.4 in patients with anti‑TB treatment times of ≥4 weeks and <4 weeks, respectively, 24 months following surgery (P=0.0895). The present study demonstrated that for patients with thoracic TB exhibiting neurological deficit, early surgical management following <4 weeks' standard anti‑TB treatment is recommended. It may relieve spinal cord compression and also benefit the early recovery of neurological function in these patients.
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1 

Magnussen A, Dinneen A and Ramesh P: Osteoarticular tuberculosis: Increasing incidence of a difficult clinical diagnosis. Br J Gen Pract. 63:385–386. 2013. View Article : Google Scholar : PubMed/NCBI

2 

De la Garza Ramos R, Goodwin CR, Abu-Bonsrah N, Bydon A, Witham TF, Wolinsky JP and Sciubba D: The epidemiology of spinal tuberculosis in the United States: An analysis of 2002–2011 data. J Neurosurg Spine. 26:507–512. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Held MFG, Hoppe S, Laubscher M, Mears S, Dix-Peek S, Zar HJ and Dunn RN: Epidemiology of musculoskeletal tuberculosis in an area with high disease prevalence. Asian Spine J. 11:405–411. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Subramani S, Shetty AP, Kanna RM and Rajasekaran S: A rare cause of late onset neurological deficit in post tuberculous kyphotic deformity-case report. J Spine Surg. 3:740–743. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Alam MS, Phan K, Karim R, Jonayed SA, Munir HK, Chakraborty S and Alam T: Surgery for spinal tuberculosis: A multi-center experience of 582 cases. J Spine Surg. 1:65–71. 2015.PubMed/NCBI

6 

Chen R, Chen Y, Zeng Y, Guo C, Chen Q and Li M: Retroperitoneal laparoscopic approach combined with anterolateral mini-incision for lumbar spine tuberculosis. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 28:1364–1367. 2014.PubMed/NCBI

7 

Qin S and Song Y; Expert Committee, : Consensus on diagnosis and treatment of osteoarticular tuberculosis in China. J Tuberc Lung Health (CHN). 1:206–212. 2012.

8 

Mavrogenis AF, Igoumenou V, Tsiavos K, Megaloikonomos P, Panagopoulos GN, Vottis C, Giannitsioti E, Papadopoulos A and Soultanis KC: When and how to operate on spondylodiscitis: A report of 13 patients. Eur J Orthop Surg Traumatol. 26:31–40. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Zhang P, Shen Y, Ding WY, Zhang W and Shang Z: The role of surgical timing in the treatment of thoracic and lumbar spinal tuberculosis. Arch Orthop Trauma Surg. 134:167–172. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Cobb JR: Outline for the study of scoliosis. Instructional course lectures. Am Acad Orthop SurgInstr Course Lect. 5:261–275. 1948.

11 

Lechner R, Putzer D, Dammerer D, Liebensteiner M, Bach C and Thaler M: Comparison of two- and three-dimensional measurement of the Cobb angle in scoliosis. Int Orthop. 41:957–962. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Vazquez XM, Rodriguez MS, Peñaranda JM, Concheiro L and Barus JI: Determining prognosis after spinal cord injury. J Forensic Leg Med. 15:20–23. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Li XL, Zhang LQ, Wu XG, Ma LP, Gao MQ and Dong WJ: Five cases of spinal tuberculosis paraplegia combined with tuberculous meningitis and analysis the timing of surgery on prognosis. Chin J Antituberculosis. 37:938–942. 2015.

14 

Liu JM, Chen XY, Zhou Y, Long XH, Chen WZ, Liu ZL, Huang SH and Yao HQ: Is nonstructural bone graft useful in surgical treatment of lumbar spinal tuberculosis?: A retrospective case-control study. Medicine (Baltimore). 95:e46772016. View Article : Google Scholar : PubMed/NCBI

15 

Hawker GA, Mian S, Kendzerska T and French M: Measures of adult pain: Visual analog scale for pain (VAS Pain), numeric rating scale for pain (NRS Pain), McGill pain questionnaire (MPQ), short-form mcgill pain questionnaire (SF-MPQ), chronic pain grade scale (CPGS), short form-36 bodily pain scale (SF-36 BPS), and measure of intermittent and constant osteoarthritis pain (ICOAP). Arthritis Care Res (Hoboken). 63 (Suppl 11):S240–S252. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Trecarichi EM, Di Meco E, Mazzotta V and Fantoni M: Tuberculous spondylodiscitis: Epidemiology, clinical features, treatment, and outcome. Eur Rev Med Pharmacol Sci. 16 (Suppl 2):S58–S72. 2012.

17 

Zhang X, Falagas ME, Vardakas KZ, Wang R, Qin R, Wang J and Liu Y: Systematic review and meta-analysis of the efficacy and safety of therapy with linezolid containing regimens in the treatment of multidrug-resistant and extensively drug-resistant tuberculosis. J Thorac Dis. 7:603–615. 2015.PubMed/NCBI

18 

Johnston JC, Khan FA and Dowdy DW: Reducing relapse in tuberculosis treatment: Is it time to reassess WHO treatment guidelines? Int J Tuberc Lung Dis. 19:6242015. View Article : Google Scholar : PubMed/NCBI

19 

Wang SI, Shen GH, Shi HC and Chiou SJ: Prescription patterns for tuberculosis treatment and adherence to treatment guidelines: A population-based study in Taiwan. Pharmacoepidemiol Drug Saf. 23:1273–1280. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Qin S: Diagnosis and treatment of spinal tuberculosis with paraplegia-correct understanding and improvement. Chin J Antituberculosis. 37:221–222. 2015.

21 

Wang R, Kong XH, Chen QY, Mei ZX and Tong XY: To explore the relation between erythrocyte sedimentation rate and postoperative recurrence of spinal tuberculosis. Zhongguo Gu Shang. 21:291–293. 2008.(In Chinese). PubMed/NCBI

22 

Sudprasert W, Piyapromdee U and Lewsirirat S: Neurological recovery determined by C-reactive protein, erythrocyte sedimentation rate and two different posterior decompressive surgical procedures: A retrospective clinical study of patients with spinal tuberculosis. J Med Assoc Thai. 98:993–1000. 2015.PubMed/NCBI

23 

Jain AK and Kumar J: Tuberculosis of spine: Neurological deficit. Eur Spine J. 22 (Suppl 4):S624–S633. 2013. View Article : Google Scholar

24 

World Health Organization (WHO), . Global tuberculosis control 2012. WHO; Geneva: 2012, https://www.who.int/tb/publications/global_report/gtbr12_main.pdf

25 

Qin S: Urgent attention and standardization of diagnosis and treatment of tuberculosis at bone and joint. Chin J Antituberculosis. 38:248–249. 2016.

26 

Yousefifard M, Rahimi-Movaghar V, Baikpour M, Ghelichkhani P, Hosseini M, Jafari A, Aziznejad H and Tafakhori A: Early versus late spinal decompression surgery in treatment of traumatic spinal cord injuries; a systematic review and meta-analysis. Emerg (Tehran). 5:e372017.PubMed/NCBI

27 

Dong J and Li J: Choice of surgical timing for spinal tuberculosis. Chin J Orthop. 2:247–249. 2014.

28 

Lan T and Qin S: The indications, time and approach of spinal tuberculosis operation. Chin J Antituberculosis. 39:327–328. 2017.

29 

Piazza M and Schuster J: Timing of surgery after spinal cord injury. Neurosurg Clin N Am. 28:31–39. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Yang L and Liu Z: Analysis and therapeutic schedule of the postoperative recurrence of bone tuberculosis. J Orthop Surg Res. 8:472013. View Article : Google Scholar : PubMed/NCBI

31 

Qin SB, Dong WJ, Fan J, Lan TL, Guan BQ, Xu SZ and Guan H: Analysis of failure reasons for postoperative patients of spinal tuberculosis complicated with paraplegia of 32 cases. Zhonghua Wai Ke Za Zhi. 45:1237–1241. 2007.(In Chinese). PubMed/NCBI

32 

Xu JZ: Standardize the treatment of spinal tuberculosis and make greater contributions to the prevention and treatment of tuberculosis in China. Chin J Orthop. 2:97–101. 2014.

33 

Moon MS, Woo YK, Lee KS, Ha KY, Kim SS and Sun DH: Posterior instrumentation and anterior interbody fusion for tuberculous kyphosis of dorsal and lumbar spines. Spine (Phila Pa 1976). 20:1910–1916. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Godal HC and Kierulf P: Failure of soluble fibrin to influence the erythrocyte sedimentation rate. Scand J Haematol. 8:415–416. 1971. View Article : Google Scholar : PubMed/NCBI

35 

Song DW: Standardized surgical treatment of spinal tuberculosis: controversy and consensus. J Spinal Surg. 16:193–194. 2018.

36 

Pang X, Shen X, Wu P, Luo C, Xu Z and Wang X: Thoracolumbar spinal tuberculosis with psoas abscesses treated by one-stage posterior transforaminal lumbar debridement, interbody fusion, posterior instrumentation, and postural drainage. Arch Orthop Trauma Surg. 133:765–772. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Jain AK: Treatment of tuberculosis of the spine with neurologic complications. Clin Orthop Relat Res. 75–84. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jia CG, Gao JG, Liu FS, Li Z, Dong ZL, Yao LM, Wang LB and Yao XW: Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience. Exp Ther Med 19: 519-526, 2020.
APA
Jia, C., Gao, J., Liu, F., Li, Z., Dong, Z., Yao, L. ... Yao, X. (2020). Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience. Experimental and Therapeutic Medicine, 19, 519-526. https://doi.org/10.3892/etm.2019.8253
MLA
Jia, C., Gao, J., Liu, F., Li, Z., Dong, Z., Yao, L., Wang, L., Yao, X."Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience". Experimental and Therapeutic Medicine 19.1 (2020): 519-526.
Chicago
Jia, C., Gao, J., Liu, F., Li, Z., Dong, Z., Yao, L., Wang, L., Yao, X."Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience". Experimental and Therapeutic Medicine 19, no. 1 (2020): 519-526. https://doi.org/10.3892/etm.2019.8253
Copy and paste a formatted citation
x
Spandidos Publications style
Jia CG, Gao JG, Liu FS, Li Z, Dong ZL, Yao LM, Wang LB and Yao XW: Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience. Exp Ther Med 19: 519-526, 2020.
APA
Jia, C., Gao, J., Liu, F., Li, Z., Dong, Z., Yao, L. ... Yao, X. (2020). Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience. Experimental and Therapeutic Medicine, 19, 519-526. https://doi.org/10.3892/etm.2019.8253
MLA
Jia, C., Gao, J., Liu, F., Li, Z., Dong, Z., Yao, L., Wang, L., Yao, X."Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience". Experimental and Therapeutic Medicine 19.1 (2020): 519-526.
Chicago
Jia, C., Gao, J., Liu, F., Li, Z., Dong, Z., Yao, L., Wang, L., Yao, X."Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti‑tuberculosis treatment: A single medical center's experience". Experimental and Therapeutic Medicine 19, no. 1 (2020): 519-526. https://doi.org/10.3892/etm.2019.8253
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