Open Access

In‑vitro models of human endometriosis (Review)

  • Authors:
    • Hongjie Fan
  • View Affiliations

  • Published online on: December 20, 2019
  • Pages: 1617-1625
  • Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Endometriosis is one of the most common benign gynecological diseases in women of reproductive age worldwide. In past decades, a number of in‑vitro models have been used to investigate the pathology and therapeutic methods for the treatment of endometriosis. The current review summarized the majority of currently available in‑vitro models, which utilize a variety of cell or tissues types, including endometriotic cell lines, primary endometrial stromal cells, endometrial stem cells, endometrial explants, peritoneal explants and immune cells. These cells or tissues are cultured individually, co‑cultured in 2D or 3D systems with various matrices or cultured in chicken chorioallantotic membranes and amniotic membranes culture systems. These models are able to represent one or more aspects of the process of endometriosis. These models are helpful and can be used to investigate the development of endometriosis and the underlying mechanisms of this disorder in detail, and help investigators select appropriate models for their experiments. Recently, the new concept of endometriosis as a fibrotic condition will lead research to investigate the differentiation of myofibroblasts and the development of fibrosis in endometriotic lesions, which will increase the development of novel models that can be used to investigate endometriotic fibrosis.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
Fan, H. (2020). In‑vitro models of human endometriosis (Review). Experimental and Therapeutic Medicine, 19, 1617-1625.
Fan, H."In‑vitro models of human endometriosis (Review)". Experimental and Therapeutic Medicine 19.3 (2020): 1617-1625.
Fan, H."In‑vitro models of human endometriosis (Review)". Experimental and Therapeutic Medicine 19, no. 3 (2020): 1617-1625.