LncRNA LINK‑A regulates ROCK1 expression in early‑stage pancreatic adenocarcinoma

  • Authors:
    • Meng Zhang
    • Rongjun Wang
    • Xun Zhao
    • Liang Lu
    • Tongshan Wang
  • View Affiliations

  • Published online on: December 31, 2019     https://doi.org/10.3892/etm.2019.8400
  • Pages: 1933-1939
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Abstract

Long intergenic non‑coding RNA for kinase activation (LINK‑A) has been characterized as an oncogenic long non‑coding (lnc)RNA in triple‑negative breast cancer and ovarian carcinoma, but its involvement in other malignancies remains elusive. In the present study, it was determined that the plasma levels of LINK‑A lncRNA and Rho‑associated protein kinase 1 (ROCK1) were significantly increased in patients with pancreatic adenocarcinoma compared with those in healthy controls. The plasma levels of LINK‑A lncRNA were positively correlated with the plasma levels of ROCK1 in pancreatic adenocarcinoma patients, but not in healthy controls. Silencing of LINK‑A led to inhibition of pancreatic adenocarcinoma cell proliferation, migration and invasion. Simultaneous overexpression of ROCK1 attenuated the inhibitory effect of LINK‑A silencing on cancer cell proliferation, migration and invasion. Overexpression of LINK‑A lncRNA led to upregulation of ROCK1 expression, while overexpression of ROCK1 had no significant effect on LINK‑A lncRNA expression. It may therefore be concluded that LINK‑A lncRNA may have a role in pancreatic adenocarcinoma, at least in part, by promoting ROCK1 expression.
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March 2020
Volume 19 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Zhang, M., Wang, R., Zhao, X., Lu, L., & Wang, T. (2020). LncRNA LINK‑A regulates ROCK1 expression in early‑stage pancreatic adenocarcinoma. Experimental and Therapeutic Medicine, 19, 1933-1939. https://doi.org/10.3892/etm.2019.8400
MLA
Zhang, M., Wang, R., Zhao, X., Lu, L., Wang, T."LncRNA LINK‑A regulates ROCK1 expression in early‑stage pancreatic adenocarcinoma". Experimental and Therapeutic Medicine 19.3 (2020): 1933-1939.
Chicago
Zhang, M., Wang, R., Zhao, X., Lu, L., Wang, T."LncRNA LINK‑A regulates ROCK1 expression in early‑stage pancreatic adenocarcinoma". Experimental and Therapeutic Medicine 19, no. 3 (2020): 1933-1939. https://doi.org/10.3892/etm.2019.8400