Expression of lncRNA MEG3 in asthma with different phenotypes and its relationship with course of disease
- Yan Feng
- Chang Yang
- Wen Yan
Affiliations: Department of Pathology, Wuhan No. 1 Hospital, Wuhan, Hubei 430022, P.R. China, Department of Respiratory Medicine, Hubei No.3 People's Hospital of Jianghan University, Wuhan, Hubei 430030, P.R. China
- Published online on: January 3, 2020 https://doi.org/10.3892/etm.2020.8414
Copyright: © Feng
et al. This is an open access article distributed under the
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Commons Attribution License.
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The purpose of this study was to explore the application value of lncRNA MEG3 in lung cancer. From March 2017 to March 2019, 119 asthma patients and 125 healthy people undergoing physical examination in the same period were selected as the research objects. The levels of lncRNA MEG3 in the peripheral blood of the two groups were compared, and the predictive value of MEG3 for asthma as well as the differences in different inflammatory phenotypes were analyzed. The expression of MEG3 was low in asthma patients (P<0.050), the diagnostic sensitivity and specificity for asthma were 79.83 and 66.40%, respectively (P<0.001), it was the lowest in mixed granulocytic asthma (P<0.050) and was negatively correlated with the course of disease (r=-0.666, P<0.001). Logistic regression analysis showed that course of disease, inflammatory phenotype and MEG3 were independent factors affecting recurrence of asthma (P<0.050). MEG3 was low expressed in asthma and had good predictive value for it; in mixed granulocytic asthma, its expression was the lowest and the course of disease was closely related. It might be the key to the diagnosis and treatment of asthma in the future.