Open Access

Expression of SUMO associated proteins in the mouse endometrium is regulated by ovarian hormones throughout the estrous cycle

  • Authors:
    • Yi Liu
    • Xiaofang Ma
    • Xuhong Chen
    • Jinsheng Chen
    • Li Yuan
    • Lili Li
    • Yaowu Bai
    • Xiaozhi Liu
  • View Affiliations

  • Published online on: January 3, 2020     https://doi.org/10.3892/etm.2020.8416
  • Pages: 1855-1863
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The modification of proteins by small ubiquitin‑like modifier (SUMO), known as SUMOylation, regulates biological function by changing protein transcription and translation. During the estrous cycle the endometrium undergoes continual change to processes including cell proliferation, secretion and exfoliation and these changes are regulated by the levels of ovarian hormones. Increasing the expression of SUMO family members has previously been shown to promote proliferation and invasion of endometrial cancer cells. However, limited research has been carried out into the expression and function of SUMO in the mammalian endometrium. In the present study, the level and localization of SUMO‑associated proteins throughout the natural estrous cycle in the mouse uterus was determined using immunohistochemical staining and western blot analysis. The association between the spatiotemporal expression of these SUMO modified proteins and SENPs in endometrium and the concentration of ovarian hormones during estrous cycle was revealed. The present study clarified the role of SUMOylation in maintenance of normal estrous cycling and may have important significance in the study of hormone‑dependent endometrial diseases.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Liu, Y., Ma, X., Chen, X., Chen, J., Yuan, L., Li, L. ... Liu, X. (2020). Expression of SUMO associated proteins in the mouse endometrium is regulated by ovarian hormones throughout the estrous cycle. Experimental and Therapeutic Medicine, 19, 1855-1863. https://doi.org/10.3892/etm.2020.8416
MLA
Liu, Y., Ma, X., Chen, X., Chen, J., Yuan, L., Li, L., Bai, Y., Liu, X."Expression of SUMO associated proteins in the mouse endometrium is regulated by ovarian hormones throughout the estrous cycle". Experimental and Therapeutic Medicine 19.3 (2020): 1855-1863.
Chicago
Liu, Y., Ma, X., Chen, X., Chen, J., Yuan, L., Li, L., Bai, Y., Liu, X."Expression of SUMO associated proteins in the mouse endometrium is regulated by ovarian hormones throughout the estrous cycle". Experimental and Therapeutic Medicine 19, no. 3 (2020): 1855-1863. https://doi.org/10.3892/etm.2020.8416