Open Access

Propofol protects human cardiac cells against chemical hypoxiainduced injury by regulating the JNK signaling pathways

  • Authors:
    • Liu Han
    • Qiang Zhuo
    • Ying Zhou
    • Yanning Qian
  • View Affiliations

  • Published online on: January 8, 2020     https://doi.org/10.3892/etm.2020.8440
  • Pages: 1864-1870
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Propofol is a widely used intravenous anesthetic shown to exert a cardioprotective role against oxidative stress and ischemia/reperfusion injury in rat cardiac H9c2 cells. However, the regulatory mechanisms and functions of propofol in human cardiomyocytes remain unknown. The present study chemically induced hypoxia with cobalt chloride (CoCl2) to mimic cardiomyocyte ischemic injury in human cardiac AC16 and HCM cells. To investigate its underlying mechanisms, propofol was added to the cells before the chemical hypoxia phase. The present results suggested that, in response to hypoxia, mitochondrial membrane potential was lost, and cardiomyocyte viability and superoxide dismutase levels decreased. However, the present results showed that reactive oxygen species and malondialdehyde levels increased. The present results suggested that these effects were significantly reversed following propofol treatment. Additionally, the present results suggested that the protective effect of propofol against CoCl2‑induced injury may be inhibited by the activation of the JNK signaling pathways. The present results indicated that propofol pre‑treatment inhibited CoCl2‑induced myocardial injury by preventing mitochondrial dysfunction, which may be partially due to the activation of the JNK signaling pathways. Therefore, propofol may exert anti‑oxidative effects in human cardiac cells. The present results suggested that propofol may be used as a treatment for oxidative stress‑related cardiac disorders.

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March 2020
Volume 19 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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APA
Han, L., Zhuo, Q., Zhou, Y., & Qian, Y. (2020). Propofol protects human cardiac cells against chemical hypoxiainduced injury by regulating the JNK signaling pathways. Experimental and Therapeutic Medicine, 19, 1864-1870. https://doi.org/10.3892/etm.2020.8440
MLA
Han, L., Zhuo, Q., Zhou, Y., Qian, Y."Propofol protects human cardiac cells against chemical hypoxiainduced injury by regulating the JNK signaling pathways". Experimental and Therapeutic Medicine 19.3 (2020): 1864-1870.
Chicago
Han, L., Zhuo, Q., Zhou, Y., Qian, Y."Propofol protects human cardiac cells against chemical hypoxiainduced injury by regulating the JNK signaling pathways". Experimental and Therapeutic Medicine 19, no. 3 (2020): 1864-1870. https://doi.org/10.3892/etm.2020.8440