Open Access

Preliminary study of abnormalities in saccade dynamics in patients with hyperthyroidism with no pre‑existing eye damage

  • Authors:
    • Yan Sun
    • Xinhui Xie
    • Yongxia Xu
    • Chen Wang
    • Xiaoming Kong
  • View Affiliations

  • Published online on: January 17, 2020     https://doi.org/10.3892/etm.2020.8461
  • Pages: 2303-2309
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study investigated the relationship between hyperthyroidism and thyroid‑associated ophthalmopathy by examining saccade dynamics to identify defects in eye tracking in patients with hyperthyroidism with no pre‑existing eye damage and sensitive indicators that discriminated eye tracking ability in hyperthyroidism. A total of 33 outpatients with hyperthyroidism and 26 healthy controls participated in visually guided saccade (VGS) analysis. Patients with hyperthyroidism were divided into groups based on their medication status (medicated vs. unmedicated). Main sequence analysis was performed to identify differences in peak velocity and duration, and a general linear model (GLM) was used to identify differences in latency, peak acceleration and peak deceleration among the groups. The present study compared differences in the Spearman's correlation coefficient of the duration of saccades and the acceleration asymmetric index (RAD) among the groups. Vmax values (Vmax was the asymptotic value of the PV of saccades of large amplitude) were significantly different between the healthy control and unmedicated‑hyperthyroidism groups. The results of the GLM‑based analysis indicated no significant differences in saccade latency among the three groups. Peak acceleration was significantly different between the healthy control and unmedicated‑hyperthyroidism groups (P<0.01). Peak deceleration was significantly different between the healthy control, unmedicated‑ and medicated‑hyperthyroidism groups (P<0.01). RAD was significantly different between the healthy control and medicated‑hyperthyroidism groups (P=0.004).The results of the present study suggested that patients with hyperthyroidism with no pre‑existing eye damage exhibited significantly altered saccade dynamics during VGS. Therefore, RAD may be used as an indicator to monitor the level of eye movement coordination.
View Figures
View References

Related Articles

Journal Cover

March 2020
Volume 19 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Sun, Y., Xie, X., Xu, Y., Wang, C., & Kong, X. (2020). Preliminary study of abnormalities in saccade dynamics in patients with hyperthyroidism with no pre‑existing eye damage. Experimental and Therapeutic Medicine, 19, 2303-2309. https://doi.org/10.3892/etm.2020.8461
MLA
Sun, Y., Xie, X., Xu, Y., Wang, C., Kong, X."Preliminary study of abnormalities in saccade dynamics in patients with hyperthyroidism with no pre‑existing eye damage". Experimental and Therapeutic Medicine 19.3 (2020): 2303-2309.
Chicago
Sun, Y., Xie, X., Xu, Y., Wang, C., Kong, X."Preliminary study of abnormalities in saccade dynamics in patients with hyperthyroidism with no pre‑existing eye damage". Experimental and Therapeutic Medicine 19, no. 3 (2020): 2303-2309. https://doi.org/10.3892/etm.2020.8461