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Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway

Retraction in: /10.3892/etm.2021.10343
  • Authors:
    • Hongzhong Ma
    • Juan Du
    • Xiaoli Feng
    • Yingjun Zhang
    • Haihuan Wang
    • Suchun Ding
    • Aijie Huang
    • Jiahai Ma

  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China, Department of Pathology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China, Department of Anesthesiology, Xi'an Beihuan Hospital, Xi'an, Shaanxi 710032, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2491-2496
    |
    Published online on: January 30, 2020
       https://doi.org/10.3892/etm.2020.8479
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Abstract

Influence of rosiglitazone on the myocardial apoptosis in rats with acute myocardial infarction (AMI) via the Toll‑like receptor 4 (TLR4)/nuclear factor‑κB (NF‑κB) signaling pathway was explored. A total of 30 healthy male Sprague‑Dawley (SD) rats were randomly divided into group A (Sham group, n=10), group B (AMI model group, n=10) and group C (AMI model + rosiglitazone group, n=10) using a random number table. It was observed through H&E staining that group A had myocardial cells with normal morphology and infiltration of few inflammatory factors, while group B had swollen myocardial cells with disorderly and irregular morphology, large and dark‑colored nuclei, infiltration of massive inflammatory factors, large amounts of fibrous tissue hyperplasia in the intercellular space, disorderly arranged, thickened and lengthened myocardial fibers with widened gaps. Moreover, group C exhibited infiltration of fewer inflammatory factors and more normal myocardial tissue structure compared with group B. According to the sirius‑red staining results, group A had normally arranged myocardial cells with a small amount of collagen hyperplasia, while group B had collagen interstitial hyperplasia and higher content of myocardial collagen than group A. Compared with that in group B, the myocardial collagen deposit was substantially reduced in group C. TUNEL staining results showed that the apoptosis rate of rat myocardial cells in group B was obviously higher than that in group A (40.37 vs. 5.23%), and it was notably lower in group C than that in group B (24.82 vs. 40.37%). According to the western blot results, the protein expression levels of the inflammatory factors TLR‑4 and NF‑κB in rat myocardial tissues were notably raised in group B compared with those in group A, and they were evidently lower in group C than those in group B. Rosiglitazone inhibits the TLR4/NF‑κB signaling pathway to produce a myocardioprotective effect.
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Copy and paste a formatted citation
Spandidos Publications style
Ma H, Du J, Feng X, Zhang Y, Wang H, Ding S, Huang A and Ma J: Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway Retraction in /10.3892/etm.2021.10343. Exp Ther Med 19: 2491-2496, 2020.
APA
Ma, H., Du, J., Feng, X., Zhang, Y., Wang, H., Ding, S. ... Ma, J. (2020). Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway Retraction in /10.3892/etm.2021.10343. Experimental and Therapeutic Medicine, 19, 2491-2496. https://doi.org/10.3892/etm.2020.8479
MLA
Ma, H., Du, J., Feng, X., Zhang, Y., Wang, H., Ding, S., Huang, A., Ma, J."Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway Retraction in /10.3892/etm.2021.10343". Experimental and Therapeutic Medicine 19.4 (2020): 2491-2496.
Chicago
Ma, H., Du, J., Feng, X., Zhang, Y., Wang, H., Ding, S., Huang, A., Ma, J."Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway Retraction in /10.3892/etm.2021.10343". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2491-2496. https://doi.org/10.3892/etm.2020.8479
Copy and paste a formatted citation
x
Spandidos Publications style
Ma H, Du J, Feng X, Zhang Y, Wang H, Ding S, Huang A and Ma J: Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway Retraction in /10.3892/etm.2021.10343. Exp Ther Med 19: 2491-2496, 2020.
APA
Ma, H., Du, J., Feng, X., Zhang, Y., Wang, H., Ding, S. ... Ma, J. (2020). Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway Retraction in /10.3892/etm.2021.10343. Experimental and Therapeutic Medicine, 19, 2491-2496. https://doi.org/10.3892/etm.2020.8479
MLA
Ma, H., Du, J., Feng, X., Zhang, Y., Wang, H., Ding, S., Huang, A., Ma, J."Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway Retraction in /10.3892/etm.2021.10343". Experimental and Therapeutic Medicine 19.4 (2020): 2491-2496.
Chicago
Ma, H., Du, J., Feng, X., Zhang, Y., Wang, H., Ding, S., Huang, A., Ma, J."Rosiglitazone alleviates myocardial apoptosis in rats with acute myocardial infarction via inhibiting TLR4/NF‑κB signaling pathway Retraction in /10.3892/etm.2021.10343". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2491-2496. https://doi.org/10.3892/etm.2020.8479
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