Transcriptome sequencing reveals dynamic changes in matrix metalloproteinases in facet joint osteoarthritis

Chen,Chu; Xu,Guanhua; Sun,Yuyu; Cui,Zhiming

doi:10.3892/etm.2020.8488

Transcriptome sequencing reveals dynamic changes in matrix metalloproteinases in facet joint osteoarthritis

Authors:
- Chu Chen
- Guanhua Xu
- Yuyu Sun
- Zhiming Cui
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Affiliations: Department of Spine Surgery, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China
Published online on: February 4, 2020 https://doi.org/10.3892/etm.2020.8488
Pages: 2475-2482
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteoarthritis is a general joint disease characterized by articular cartilage degeneration. The extracellular matrix is a principal component in articular cartilage. The dynamic remodeling of the extracellular matrix is involved in the pathological degradation of the articular cartilage. Facet joint osteoarthritis (FJOA) is a common form of osteoarthritis that occurs in the posterior aspect of the vertebral column. However, to the best of our knowledge, the current understanding of the genetic changes in FJOA is limited. The most significantly differentially expressed genes and Gene Ontology categories in FJOA were identified by transcriptome sequencing analysis. The extracellular matrix, matrix metalloproteinases (MMPs) and proteinases of the extracellular matrix were highly involved in FJOA. The canonical signaling pathway ‘inhibition of matrix metalloproteinases’ was further studied in detail by identifying and validating differentially expressed genes in the signaling pathway. Taken together, the present study revealed changes in MMP‑related genes in FJOA and showed the importance of extracellular matrix remodeling in FJOA from a genetic aspect.

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