Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2020 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2020 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1

  • Authors:
    • Xiaolan Yin
    • Zongtao Chai
    • Xiaoting Sun
    • Jin Chen
    • Xiufang Wu
    • Liying Yang
    • Xiaobao Zhou
    • Feng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Changhai Hospital (Hongkou District) Affiliated with Naval Medical University, Shanghai 200081, P.R. China, Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital Affiliated with Naval Medical University, Shanghai 200081, P.R. China, General Practitioners of Traditional Chinese Medicine, Wusong Street Community Health Service Center, Shanghai 200940, P.R. China
  • Pages: 2757-2765
    |
    Published online on: February 7, 2020
       https://doi.org/10.3892/etm.2020.8502
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNA‑96 (miR‑96) has been revealed serve an oncogenic role in various types of cancer. However, the role of miR‑96 in cholangiocarcinoma (CCA) development and progression is yet to be elucidated. Thus, the aim of the present study was to investigate the role of miR‑96 in CCA. The expression pattern of miR‑96 in CCA tissues and cell lines was evaluated using reverse transcription‑quantitative PCR analysis. Kaplan‑Meier curves and Cox regression analyses were conducted to investigate the prognostic significance of miR‑96 in CCA. Cell Counting Kit‑8 and Transwell assays were performed to identify the functions of miR‑96. The association between miR‑96 and metastasis suppressor‑1 (MTSS1) was verified using a dual‑luciferase assay. The results demonstrated that miR‑96 expression levels were increased in CCA tissues and cell lines compared with those in adjacent normal tissues and normal human intrahepatic biliary epithelial cell lines, respectively. High expression levels of miR‑96 were significantly associated with lymph node metastasis, differentiation and TNM stage. In addition, upregulated expression of miR‑96 was associated with a poorer prognosis and was predicted to be a prognostic factor in patients with CCA. Overexpression of miR‑96 in vitro promoted CCA cell proliferation, migration and invasion. Additionally, MTSS1 was identified as a direct target of miR‑96. The results of the present study indicated the clinical and biological importance of miR‑96 as an oncogene in CCA. miR‑96 may represent an independent prognostic biomarker and may promote CCA cell proliferation, migration and invasion by targeting MTSS1.
View Figures
View References

1 

Rizvi S and Gores GJ: Pathogenesis, diagnosis, and management of cholangiocarcinoma. Gastroenterology. 145:1215–1229. 2013.PubMed/NCBI View Article : Google Scholar

2 

Khan AS and Dageforde LA: Cholangiocarcinoma. Surg Clin North Am. 99:315–335. 2019.PubMed/NCBI View Article : Google Scholar

3 

Khan SA, Tavolari S and Brandi G: Cholangiocarcinoma: Epidemiology and risk factors. Liver Int. 39 (Suppl 1):S19–S31. 2019.PubMed/NCBI View Article : Google Scholar

4 

Razumilava N and Gores GJ: Cholangiocarcinoma. Lancet. 383:2168–2179. 2014.PubMed/NCBI View Article : Google Scholar

5 

Patel T: Cholangiocarcinoma-controversies and challenges. Nat Rev Gastroenterol Hepatol. 8:189–200. 2011.PubMed/NCBI View Article : Google Scholar

6 

Squadroni M, Tondulli L, Gatta G, Mosconi S, Beretta G and Labianca R: Cholangiocarcinoma. Crit Rev Oncol Hematol. 116:11–31. 2017.

7 

Blechacz B: Cholangiocarcinoma: Current knowledge and new developments. Gut Liver. 11:13–26. 2017.PubMed/NCBI View Article : Google Scholar

8 

Ebata T, Mizuno T, Yokoyama Y, Igami T, Sugawara G and Nagino M: Surgical resection for Bismuth type IV perihilar cholangiocarcinoma. Br J Surg. 105:829–838. 2018.PubMed/NCBI View Article : Google Scholar

9 

Valencia-Sanchez MA, Liu J, Hannon GJ and Parker R: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 20:515–524. 2006.PubMed/NCBI View Article : Google Scholar

10 

Wei R, Ye X, Zhao Y, Jia N, Liu T, Lian W, Wei H, Zhang G and Song L: MicroRNA-218 inhibits the cell proliferation and migration in clear cell renal cell carcinoma through targeting cancerous inhibitor of protein phosphatase 2A. Oncol Lett. 17:3211–3218. 2019.PubMed/NCBI View Article : Google Scholar

11 

Yao R, Zheng H, Wu L and Cai P: miRNA-641 inhibits the proliferation, migration, and invasion and induces apoptosis of cervical cancer cells by directly targeting ZEB1. Onco Targets Ther. 11:8965–8976. 2018.PubMed/NCBI View Article : Google Scholar

12 

Hrdlicka HC, Lee SK and Delany AM: MicroRNAs are critical regulators of osteoclast differentiation. Curr Mol Biol Rep. 5:65–74. 2019.PubMed/NCBI View Article : Google Scholar

13 

Iwai N, Yasui K, Tomie A, Gen Y, Terasaki K, Kitaichi T, Soda T, Yamada N, Dohi O, Seko Y, et al: Oncogenic miR-96-5p inhibits apoptosis by targeting the caspase-9 gene in hepatocellular carcinoma. Int J Oncol. 53:237–245. 2018.PubMed/NCBI View Article : Google Scholar

14 

Iseki Y, Shibutani M, Maeda K, Nagahara H, Fukuoka T, Matsutani S, Hirakawa K and Ohira M: MicroRNA-96 promotes tumor invasion in colorectal cancer via RECK. Anticancer Res. 38:2031–2035. 2018.PubMed/NCBI View Article : Google Scholar

15 

Xie W, Sun F, Chen L and Cao X: miR-96 promotes breast cancer metastasis by suppressing MTSS1. Oncol Lett. 15:3464–3471. 2018.PubMed/NCBI View Article : Google Scholar

16 

Collins AL, Wojcik S, Liu J, Frankel WL, Alder H, Yu L, Schmittgen TD, Croce CM and Bloomston M: A differential microRNA profile distinguishes cholangiocarcinoma from pancreatic adenocarcinoma. Ann Surg Oncol. 21:133–138. 2014.PubMed/NCBI View Article : Google Scholar

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

18 

Shi W, Hasimu G, Wang Y, Li N, Chen M and Zhang H: MTSS1 is an independent prognostic biomarker for survival in intrahepatic cholangiocarcinoma patients. Am J Transl Res. 7:1974–1983. 2015.PubMed/NCBI

19 

Wang F, Liu Y and Zhang H: Loss of MTSS1 expression is an independent prognostic factor for Hilar cholangiocarcinoma. Pathol Oncol Res. 19:815–820. 2013.PubMed/NCBI View Article : Google Scholar

20 

Kirstein MM and Vogel A: Epidemiology and risk factors of cholangiocarcinoma. Visc Med. 32:395–400. 2016.PubMed/NCBI View Article : Google Scholar

21 

Puik JR, Meijer LL, Le Large TY, Prado MM, Frampton AE, Kazemier G and Giovannetti E: miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma. Pharmacogenomics. 18:1343–1358. 2017.PubMed/NCBI View Article : Google Scholar

22 

Khan SA, Davidson BR, Goldin RD, Heaton N, Karani J, Pereira SP, Rosenberg WM, Tait P, Taylor-Robinson SD, Thillainayagam AV, et al: Guidelines for the diagnosis and treatment of cholangiocarcinoma: An update. Gut. 61:1657–1669. 2012.PubMed/NCBI View Article : Google Scholar

23 

Yang ZQ, Wu CA and Cheng YX: Prognostic value of microRNA-133a expression and its clinicopathologic significance in Non-small cell lung cancer: A comprehensive study based on Meta-analysis and the TCGA database. Oncol Res Treat. 41:762–768. 2018.PubMed/NCBI View Article : Google Scholar

24 

Wang JR, Liu B, Zhou L and Huang YX: MicroRNA-124-3p suppresses cell migration and invasion by targeting ITGA3 signaling in bladder cancer. Cancer Biomark. 24:159–172. 2019.PubMed/NCBI View Article : Google Scholar

25 

Karimi N, Ali Hosseinpour Feizi M, Safaralizadeh R, Hashemzadeh S, Baradaran B, Shokouhi B and Teimourian S: Serum overexpression of miR-301a and miR-23a in patients with colorectal cancer. J Chin Med Assoc. 82:215–220. 2019.PubMed/NCBI View Article : Google Scholar

26 

Sekar D, Mani P, Biruntha M, Sivagurunathan P and Karthigeyan M: Dissecting the functional role of microRNA 21 in osteosarcoma. Cancer Gene Ther. 26:179–182. 2019.PubMed/NCBI View Article : Google Scholar

27 

Papadaki C, Stoupis G, Tsalikis L, Monastirioti A, Papadaki M, Maliotis N, Stratigos M, Mastrostamatis G, Mavroudis D and Agelaki S: Circulating miRNAs as a marker of metastatic disease and prognostic factor in metastatic breast cancer. Oncotarget. 10:966–981. 2019.PubMed/NCBI View Article : Google Scholar

28 

Bertoli G, Cava C and Castiglioni I: MicroRNAs: New biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer. Theranostics. 5:1122–1143. 2015.PubMed/NCBI View Article : Google Scholar

29 

Qin C, Huang RY and Wang ZX: Potential role of miR-100 in cancer diagnosis, prognosis, and therapy. Tumour Biol. 36:1403–1409. 2015.PubMed/NCBI View Article : Google Scholar

30 

Sun D, Zhong J, Wei W, Chen X, Liu J and Hu Z: Identification of microRNA expression in sentinel lymph nodes from patients with breast cancer via RNA sequencing for diagnostic accuracy. J Gene Med. 21(e3075)2019.PubMed/NCBI View Article : Google Scholar

31 

Fei X, Zhang J, Zhao Y, Sun M, Zhao H and Li S: MiR-96 promotes invasion and metastasis by targeting GPC3 in non-small cell lung cancer cells. Oncol Lett. 15:9081–9086. 2018.PubMed/NCBI View Article : Google Scholar

32 

Ma X, Shi W, Peng L, Qin X and Hui Y: MiR-96 enhances cellular proliferation and tumorigenicity of human cervical carcinoma cells through PTPN9. Saudi J Biol Sci. 25:863–867. 2018.PubMed/NCBI View Article : Google Scholar

33 

Li Z and Wang Y: miR-96 targets SOX6 and promotes proliferation, migration, and invasion of hepatocellular carcinoma. Biochem Cell Biol. 96:365–371. 2018.PubMed/NCBI View Article : Google Scholar

34 

Yuan J, Dong R, Liu F, Zhan L, Liu Y, Wei J and Wang N: The miR-183/182/96 cluster functions as a potential carcinogenic factor and prognostic factor in kidney renal clear cell carcinoma. Exp Ther Med. 17:2457–2464. 2019.PubMed/NCBI View Article : Google Scholar

35 

Sha HH, Wang DD, Chen D, Liu SW, Wang Z, Yan DL, Dong SC and Feng JF: MiR-138: A promising therapeutic target for cancer. Tumour Biol. 39(1010428317697575)2017.PubMed/NCBI View Article : Google Scholar

36 

Zhou MH, Zhou HW, Liu M and Sun JZ: The role of miR-92b in cholangiocarcinoma patients. Int J Biol Markers. 33:293–300. 2018.PubMed/NCBI View Article : Google Scholar

37 

Yang N, Zhou J, Li Q, Han F and Yu Z: miR-96 exerts carcinogenic effect by activating AKT/GSK-3β/β-catenin signaling pathway through targeting inhibition of FOXO1 in hepatocellular carcinoma. Cancer Cell Int. 19(38)2019.PubMed/NCBI View Article : Google Scholar

38 

Liu K, Jiao XD, Hao JL, Qin BD, Wu Y, Chen W, Liu J, He X and Zang YS: MTSS1 inhibits metastatic potential and induces G2/M phase cell cycle arrest in gastric cancer. Onco Targets Ther. 12:5143–5152. 2019.PubMed/NCBI View Article : Google Scholar

39 

Du P, Wang S, Tang X, An C, Yang Y and Jiang WG: Reduced expression of metastasis Suppressor-1 (MTSS1) accelerates progression of human bladder uroepithelium cell carcinoma. Anticancer Res. 37:4499–4505. 2017.PubMed/NCBI View Article : Google Scholar

40 

Taylor MD, Bollt O, Iyer SC and Robertson GP: Metastasis suppressor 1 (MTSS1) expression is associated with reduced in-vivo metastasis and enhanced patient survival in lung adenocarcinoma. Clin Exp Metastasis. 35:15–23. 2018.PubMed/NCBI View Article : Google Scholar

41 

Wang H, Zhao Y, Cao L, Zhang J, Wang Y and Xu M: Metastasis suppressor protein 1 regulated by PTEN suppresses invasion, migration, and EMT of gastric carcinoma by inactivating PI3K/AKT signaling. J Cell Biochem. 120:3447–3454. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yin X, Chai Z, Sun X, Chen J, Wu X, Yang L, Zhou X and Liu F: Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1. Exp Ther Med 19: 2757-2765, 2020.
APA
Yin, X., Chai, Z., Sun, X., Chen, J., Wu, X., Yang, L. ... Liu, F. (2020). Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1. Experimental and Therapeutic Medicine, 19, 2757-2765. https://doi.org/10.3892/etm.2020.8502
MLA
Yin, X., Chai, Z., Sun, X., Chen, J., Wu, X., Yang, L., Zhou, X., Liu, F."Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1". Experimental and Therapeutic Medicine 19.4 (2020): 2757-2765.
Chicago
Yin, X., Chai, Z., Sun, X., Chen, J., Wu, X., Yang, L., Zhou, X., Liu, F."Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2757-2765. https://doi.org/10.3892/etm.2020.8502
Copy and paste a formatted citation
x
Spandidos Publications style
Yin X, Chai Z, Sun X, Chen J, Wu X, Yang L, Zhou X and Liu F: Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1. Exp Ther Med 19: 2757-2765, 2020.
APA
Yin, X., Chai, Z., Sun, X., Chen, J., Wu, X., Yang, L. ... Liu, F. (2020). Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1. Experimental and Therapeutic Medicine, 19, 2757-2765. https://doi.org/10.3892/etm.2020.8502
MLA
Yin, X., Chai, Z., Sun, X., Chen, J., Wu, X., Yang, L., Zhou, X., Liu, F."Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1". Experimental and Therapeutic Medicine 19.4 (2020): 2757-2765.
Chicago
Yin, X., Chai, Z., Sun, X., Chen, J., Wu, X., Yang, L., Zhou, X., Liu, F."Overexpression of microRNA‑96 is associated with poor prognosis and promotes proliferation, migration and invasion in cholangiocarcinoma cells via MTSS1". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2757-2765. https://doi.org/10.3892/etm.2020.8502
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team