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Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes

  • Authors:
    • Si‑Yu Chen
    • Ying Wang
    • Chun‑Lei Zhang
    • Ze‑Min Yang
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China, Department of Stomatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2707-2719
    |
    Published online on: February 10, 2020
       https://doi.org/10.3892/etm.2020.8505
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Abstract

Patients with type 2 diabetes mellitus (T2DM) present with dry mouth, polydipsia and taste impairment due to salivary secretion disorder. However, the underlying functional mechanism of T2DM remains unknown. The present study found that T2DM rats had significantly lower salivary flow rate and salivary alpha amylase activity, and attenuated salivary secretion responses to acid stimulation compared with control rats. Histopathological observation found that T2DM rats had inflammatory cell infiltration with increased expressions of IL‑6 and TNF‑α, oxidative stress, including decreased total superoxide dismutase activity and increased malondialdehyde content, and decreased expressions of β1 adrenergic receptor, cholinergic receptor, aquaporin‑5 and protein kinase A in salivary glands, in particular the parotid gland. These results indicated that parotid gland impairment was more severe compared with submandibular gland impairment. Reduced salivary secretion may be associated with histopathological lesions and decreased regulation in secretory pathways in salivary glands.
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Copy and paste a formatted citation
Spandidos Publications style
Chen SY, Wang Y, Zhang CL and Yang ZM: Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes. Exp Ther Med 19: 2707-2719, 2020.
APA
Chen, S., Wang, Y., Zhang, C., & Yang, Z. (2020). Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes. Experimental and Therapeutic Medicine, 19, 2707-2719. https://doi.org/10.3892/etm.2020.8505
MLA
Chen, S., Wang, Y., Zhang, C., Yang, Z."Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes". Experimental and Therapeutic Medicine 19.4 (2020): 2707-2719.
Chicago
Chen, S., Wang, Y., Zhang, C., Yang, Z."Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2707-2719. https://doi.org/10.3892/etm.2020.8505
Copy and paste a formatted citation
x
Spandidos Publications style
Chen SY, Wang Y, Zhang CL and Yang ZM: Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes. Exp Ther Med 19: 2707-2719, 2020.
APA
Chen, S., Wang, Y., Zhang, C., & Yang, Z. (2020). Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes. Experimental and Therapeutic Medicine, 19, 2707-2719. https://doi.org/10.3892/etm.2020.8505
MLA
Chen, S., Wang, Y., Zhang, C., Yang, Z."Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes". Experimental and Therapeutic Medicine 19.4 (2020): 2707-2719.
Chicago
Chen, S., Wang, Y., Zhang, C., Yang, Z."Decreased basal and stimulated salivary parameters by histopathological lesions and secretory dysfunction of parotid and submandibular glands in rats with type 2 diabetes". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2707-2719. https://doi.org/10.3892/etm.2020.8505
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