Open Access

Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension

  • Authors:
    • Wanjun Lu
    • Shuhao Gong
    • Juan Li
    • Ying Wang
  • View Affiliations

  • Published online on: February 10, 2020     https://doi.org/10.3892/etm.2020.8506
  • Pages: 2615-2621
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study analyzed the clinicopathological features and prognosis in patients with idiopathic membranous nephropathy (IMN) with hypertension. In the hypertension group, significant differences were found in the age, hypertension history, systolic blood pressure, diastolic blood pressure (DBP), mean arterial pressure, albumin, serum creatinine, low‑density lipoprotein, 24 h urine protein levels, calculated estimated glomerular filtration rate (e‑GFR), glomerular sclerosis, segmental sclerosis, ischemic sclerosis, interstitial fibrosis, tubular atrophy and vascular lesion compared with the non‑hypertension group (P<0.05). The average follow‑up time was 35.70 months (5.10‑103.77 months). In total, 54 patients reported a 50% decline in e‑GFR, eight patients reported progression of disease to end‑stage renal disease (ESRD) and nine cases of mortality were reported. Survival analysis results suggested that patients with hypertension had a lower cumulative renal survival rate than those without hypertension (P=0.034). Multivariate Cox hazards regression analysis results suggested that DBP [hazard ratio (H), 5.160; CI, 0.865‑0.989; P=0.023], age (H, 4.839; CI, 1.008‑1.142; P=0.028), sex (H, 5.680; CI, 0.031‑0.714; P=0.017), serum creatinine (H, 20.920; CI, 1.035‑1.089; P<0.001), uric acid (H, 4.783; CI, 0.982‑0.0.999; P=0.029), 24 h urine protein (H, 6.318; CI, 1.079‑1.850; P=0.012), e‑GFR (H, 4.008; CI, 1.001‑1.062; P=0.045) and glomerular sclerosis (H, 8.722; CI, 1.860‑21.559; P=0.003), segmental sclerosis (H, 7.737; CI, 7.770‑13.219; P=0.005), percentage of ischemic sclerosis (H, 4.729; CI, 1.444‑11.945; P=0.030), crescents (H, 5.938; CI, 0.003‑0.526; P=0.015), interstitial fibrosis and tubular atrophy (H, 8.128; CI, 0.005‑1.052; P=0.043), and vascular lesion (H, 4.049; CI, 1.030‑9.766; P=0.044) were risk factors for the development of IMN into ESRD. The results suggested that DBP may be an independent risk factor for the development of IMN with hypertension.
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April-2020
Volume 19 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lu W, Gong S, Li J and Wang Y: Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension. Exp Ther Med 19: 2615-2621, 2020
APA
Lu, W., Gong, S., Li, J., & Wang, Y. (2020). Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension. Experimental and Therapeutic Medicine, 19, 2615-2621. https://doi.org/10.3892/etm.2020.8506
MLA
Lu, W., Gong, S., Li, J., Wang, Y."Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension". Experimental and Therapeutic Medicine 19.4 (2020): 2615-2621.
Chicago
Lu, W., Gong, S., Li, J., Wang, Y."Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2615-2621. https://doi.org/10.3892/etm.2020.8506