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Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension

  • Authors:
    • Wanjun Lu
    • Shuhao Gong
    • Juan Li
    • Ying Wang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2615-2621
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    Published online on: February 10, 2020
       https://doi.org/10.3892/etm.2020.8506
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Abstract

The present study analyzed the clinicopathological features and prognosis in patients with idiopathic membranous nephropathy (IMN) with hypertension. In the hypertension group, significant differences were found in the age, hypertension history, systolic blood pressure, diastolic blood pressure (DBP), mean arterial pressure, albumin, serum creatinine, low‑density lipoprotein, 24 h urine protein levels, calculated estimated glomerular filtration rate (e‑GFR), glomerular sclerosis, segmental sclerosis, ischemic sclerosis, interstitial fibrosis, tubular atrophy and vascular lesion compared with the non‑hypertension group (P<0.05). The average follow‑up time was 35.70 months (5.10‑103.77 months). In total, 54 patients reported a 50% decline in e‑GFR, eight patients reported progression of disease to end‑stage renal disease (ESRD) and nine cases of mortality were reported. Survival analysis results suggested that patients with hypertension had a lower cumulative renal survival rate than those without hypertension (P=0.034). Multivariate Cox hazards regression analysis results suggested that DBP [hazard ratio (H), 5.160; CI, 0.865‑0.989; P=0.023], age (H, 4.839; CI, 1.008‑1.142; P=0.028), sex (H, 5.680; CI, 0.031‑0.714; P=0.017), serum creatinine (H, 20.920; CI, 1.035‑1.089; P<0.001), uric acid (H, 4.783; CI, 0.982‑0.0.999; P=0.029), 24 h urine protein (H, 6.318; CI, 1.079‑1.850; P=0.012), e‑GFR (H, 4.008; CI, 1.001‑1.062; P=0.045) and glomerular sclerosis (H, 8.722; CI, 1.860‑21.559; P=0.003), segmental sclerosis (H, 7.737; CI, 7.770‑13.219; P=0.005), percentage of ischemic sclerosis (H, 4.729; CI, 1.444‑11.945; P=0.030), crescents (H, 5.938; CI, 0.003‑0.526; P=0.015), interstitial fibrosis and tubular atrophy (H, 8.128; CI, 0.005‑1.052; P=0.043), and vascular lesion (H, 4.049; CI, 1.030‑9.766; P=0.044) were risk factors for the development of IMN into ESRD. The results suggested that DBP may be an independent risk factor for the development of IMN with hypertension.
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Copy and paste a formatted citation
Spandidos Publications style
Lu W, Gong S, Li J and Wang Y: Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension. Exp Ther Med 19: 2615-2621, 2020.
APA
Lu, W., Gong, S., Li, J., & Wang, Y. (2020). Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension. Experimental and Therapeutic Medicine, 19, 2615-2621. https://doi.org/10.3892/etm.2020.8506
MLA
Lu, W., Gong, S., Li, J., Wang, Y."Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension". Experimental and Therapeutic Medicine 19.4 (2020): 2615-2621.
Chicago
Lu, W., Gong, S., Li, J., Wang, Y."Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2615-2621. https://doi.org/10.3892/etm.2020.8506
Copy and paste a formatted citation
x
Spandidos Publications style
Lu W, Gong S, Li J and Wang Y: Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension. Exp Ther Med 19: 2615-2621, 2020.
APA
Lu, W., Gong, S., Li, J., & Wang, Y. (2020). Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension. Experimental and Therapeutic Medicine, 19, 2615-2621. https://doi.org/10.3892/etm.2020.8506
MLA
Lu, W., Gong, S., Li, J., Wang, Y."Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension". Experimental and Therapeutic Medicine 19.4 (2020): 2615-2621.
Chicago
Lu, W., Gong, S., Li, J., Wang, Y."Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2615-2621. https://doi.org/10.3892/etm.2020.8506
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