Neuroprotection in glaucoma‑electrophysiology (Review)

Lešták,Ján; Fůs,Martin

doi:10.3892/etm.2020.8509

Neuroprotection in glaucoma‑electrophysiology (Review)

Authors:
- Ján Lešták
- Martin Fůs
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Affiliations: Eye Clinic, JL Faculty of Biomedical Engineering CTU in Prague, 158 00 Prague 5, Czech Republic
Published online on: February 10, 2020 https://doi.org/10.3892/etm.2020.8509
Pages: 2401-2405
Copyright: © Lešták et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hypertensive glaucoma is defined as a group of diseases with progressive loss of the neuroretinal margin of the optic disc that causes characteristic degenerative optic neuropathy. The present study provided an updated summary of the physiology and pathology of neurotransmission in the visual path, with the focus on glaucoma. The results of positron emission tomography, functional magnetic resonance imaging and mainly electrophysiological methods demonstrated pathogenesis of nerve cell damage in the visual pathway. Based on these conclusions, neuroprotection in glaucoma was proposed. This consists mainly of the reduction of the intraocular pressure. It is followed by a decrease of glutamate in the synaptic cleft and blockade of its binding to the NMDA receptors. The supply of energy substrates to altered nerve cells is also indispensable. Therapy should be systemic due to impairment of the complete visual path.

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