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Neuroprotection in glaucoma‑electrophysiology (Review)

  • Authors:
    • Ján Lešták
    • Martin Fůs
  • View Affiliations / Copyright

    Affiliations: Eye Clinic, JL Faculty of Biomedical Engineering CTU in Prague, 158 00 Prague 5, Czech Republic
    Copyright: © Lešták et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2401-2405
    |
    Published online on: February 10, 2020
       https://doi.org/10.3892/etm.2020.8509
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Abstract

Hypertensive glaucoma is defined as a group of diseases with progressive loss of the neuroretinal margin of the optic disc that causes characteristic degenerative optic neuropathy. The present study provided an updated summary of the physiology and pathology of neurotransmission in the visual path, with the focus on glaucoma. The results of positron emission tomography, functional magnetic resonance imaging and mainly electrophysiological methods demonstrated pathogenesis of nerve cell damage in the visual pathway. Based on these conclusions, neuroprotection in glaucoma was proposed. This consists mainly of the reduction of the intraocular pressure. It is followed by a decrease of glutamate in the synaptic cleft and blockade of its binding to the NMDA receptors. The supply of energy substrates to altered nerve cells is also indispensable. Therapy should be systemic due to impairment of the complete visual path.
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Copy and paste a formatted citation
Spandidos Publications style
Lešták J and Fůs M: Neuroprotection in glaucoma‑electrophysiology (Review). Exp Ther Med 19: 2401-2405, 2020.
APA
Lešták, J., & Fůs, M. (2020). Neuroprotection in glaucoma‑electrophysiology (Review). Experimental and Therapeutic Medicine, 19, 2401-2405. https://doi.org/10.3892/etm.2020.8509
MLA
Lešták, J., Fůs, M."Neuroprotection in glaucoma‑electrophysiology (Review)". Experimental and Therapeutic Medicine 19.4 (2020): 2401-2405.
Chicago
Lešták, J., Fůs, M."Neuroprotection in glaucoma‑electrophysiology (Review)". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2401-2405. https://doi.org/10.3892/etm.2020.8509
Copy and paste a formatted citation
x
Spandidos Publications style
Lešták J and Fůs M: Neuroprotection in glaucoma‑electrophysiology (Review). Exp Ther Med 19: 2401-2405, 2020.
APA
Lešták, J., & Fůs, M. (2020). Neuroprotection in glaucoma‑electrophysiology (Review). Experimental and Therapeutic Medicine, 19, 2401-2405. https://doi.org/10.3892/etm.2020.8509
MLA
Lešták, J., Fůs, M."Neuroprotection in glaucoma‑electrophysiology (Review)". Experimental and Therapeutic Medicine 19.4 (2020): 2401-2405.
Chicago
Lešták, J., Fůs, M."Neuroprotection in glaucoma‑electrophysiology (Review)". Experimental and Therapeutic Medicine 19, no. 4 (2020): 2401-2405. https://doi.org/10.3892/etm.2020.8509
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