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miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma

  • Authors:
    • Maosong Wu
    • Yongsheng Tang
    • Gang Hu
    • Chunjian Yang
    • Kaichuang Ye
    • Xianluo Liu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The Second People's Hospital of Hefei, Hefei, Anhui 230011, P.R. China, Department of Vascular Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 230011, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3017-3023
    |
    Published online on: February 25, 2020
       https://doi.org/10.3892/etm.2020.8546
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Abstract

Hemangiomas (HAs) are benign neoplasms of the vasculature. MicroRNA‑4458 (miR‑4458) has been reported to function as a tumor suppressor in multiple malignancies, but its biological function in HAs remains unknown. In the present study, the potential role of miR‑4458 in HA‑derived endothelial cells (HDECs) was investigated. Firstly, reverse‑transcription‑quantitative PCR analysis was used to confirm the expression of miR‑4458 in HDECs following transfection with miR‑4458 mimics or inhibitor. Subsequently, MTT and EdU assays were performed and subsequently determined that miR‑4458 overexpression significantly inhibited proliferation, and knockdown promoted cell proliferation in HDECs. Flow cytometry analysis revealed that miR‑4458 overexpression induced cell cycle arrest, whereas knockdown reversed G0/G1 phase arrest and apoptosis. Furthermore, insulin‑like growth factor 1 receptor (IGF1R) was identified as a target of miR‑4458. IGF1R knockdown enhanced the effects of miR‑4458 on cell proliferation, cell cycle G0/G1 phase arrest and apoptosis in HDECs. Taken together, the results revealed that miR‑4458 targeting of IGF1R may serve as a novel therapeutic strategy for treating patients with HAs.
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1 

Spence-Shishido AA, Good WV, Baselga E and Frieden IJ: Hemangiomas and the eye. Clin Dermatol. 33:170–182. 2015.PubMed/NCBI View Article : Google Scholar

2 

Phillips JD, Zhang H, Wei T and Richter GT: Expression of β-adrenergic receptor subtypes in proliferative, involuted, and propranolol-responsive infantile hemangiomas. JAMA Facial Plast Surg. 19:102–107. 2017.PubMed/NCBI View Article : Google Scholar

3 

Janmohamed SR, Madern GC, de Laat PC and Oranje AP: Educational paper: Pathogenesis of infantile haemangioma, an update 2014 (part I). Eur J Pediatr. 174:97–103. 2015.PubMed/NCBI View Article : Google Scholar

4 

Nakayama H, Huang L, Kelly RP, Oudenaarden CR, Dagher A, Hofmann NA, Moses MA, Bischoff J and Klagsbrun M: Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins. Biochem Biophys Res Commun. 464:126–132. 2015.PubMed/NCBI View Article : Google Scholar

5 

Itinteang T, Davis PF and Tan ST: Infantile hemangiomas exhibit neural crest and pericyte markers. Ann Plast Surg. 74(383)2015.PubMed/NCBI View Article : Google Scholar

6 

Acunzo M, Romano G, Wernicke D and Croce CM: MicroRNA and cancer-a brief overview. Adv Biol Regul. 57:1–9. 2015.PubMed/NCBI View Article : Google Scholar

7 

Koshizuka K, Nohata N, Hanazawa T, Kikkawa N, Arai T, Okato A, Fukumoto I, Katada K, Okamoto Y and Seki N: Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: Dual strands of pre-miR-150 as antitumor miRNAs. Oncotarget. 8:30288–30304. 2017.PubMed/NCBI View Article : Google Scholar

8 

Hayes J, Peruzzi PP and Lawler S: MicroRNAs in cancer: Biomarkers, functions and therapy. Trends Mol Med. 20:460–469. 2014.PubMed/NCBI View Article : Google Scholar

9 

Biswas A, Pan X, Meyer M, Khanna S, Roy S, Pearson G, Kirschner R, Witman P, Faith EF, Sen CK and Gordillo GM: Urinary excretion of MicroRNA-126 is a biomarker for hemangioma proliferation. Plast Reconstr Surg. 139(1277e-1284e)2017.PubMed/NCBI View Article : Google Scholar

10 

Fei Z, Qiu M, Qi X, Dai Y, Wang S, Quan Z, Liu Y and Ou J: MicroRNA-424 suppresses the proliferation of hemangioma-derived endothelial cells by targeting VEGFR-2. Mol Med Rep. 18:4065–4071. 2018.PubMed/NCBI View Article : Google Scholar

11 

Huang C, Huang J, Ma P and Yu G: microRNA-143 acts as a suppressor of hemangioma growth by targeting Bcl-2. Gene. 628:211–217. 2017.PubMed/NCBI View Article : Google Scholar

12 

Mong EF, Akat KM, Canfield J, Lockhart J, VanWye J, Matar A, Tsibris JCM, Wu JK, Tuschl T and Totary-Jain H: Modulation of LIN28B/Let-7 signaling by propranolol contributes to infantile hemangioma involution. Arterioscler Thromb Vasc Biol. 38:1321–1332. 2018.PubMed/NCBI View Article : Google Scholar

13 

Liu CH, Lv DS, Li M, Sun G, Zhang XF and Bai Y: MicroRNA-4458 suppresses the proliferation of human lung cancer cells in vitro by directly targeting Lin28B. Acta Pharmacol Sin. 38:1297–1304. 2017.PubMed/NCBI View Article : Google Scholar

14 

Tang D, Sun B, Yu H, Yang Z and Zhu L: Tumor-suppressing effect of miR-4458 on human hepatocellular carcinoma. Cell Physiol Biochem. 35:1797–1807. 2015.PubMed/NCBI View Article : Google Scholar

15 

Qin Y, Cheng C, Lu H and Wang Y: miR-4458 suppresses glycolysis and lactate production by directly targeting hexokinase2 in colon cancer cells. Biochem Biophys Res Commun. 469:37–43. 2016.PubMed/NCBI View Article : Google Scholar

16 

Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, et al: Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 8(14892)2017.PubMed/NCBI View Article : Google Scholar

17 

Cannarella R, Mattina T, Condorelli RA, Mongioì LM, Pandini G, La Vignera S and Calogero AE: Chromosome 15 structural abnormalities: Effect on IGF1R gene expression and function. Endocr Connect. 6:528–539. 2017.PubMed/NCBI View Article : Google Scholar

18 

Taliaferro-Smith LT, Oberlick E, Liu T, McGlothen T, Alcaide T, Tobin R, Donnelly S, Commander R, Kline E, Nagaraju GP, et al: FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells. Oncotarget. 6:4757–4772. 2014.PubMed/NCBI View Article : Google Scholar

19 

Ball MW, Bezerra SM, Chaux A, Faraj SF, Gonzalez-Roibon N, Munari E, Sharma R, Bivalacqua TJ, Netto GJ and Burnett AL: Overexpression of insulin-like growth factor-1 receptor is associated with penile cancer progression. Urology. 92:51–56. 2016.PubMed/NCBI View Article : Google Scholar

20 

Qian Y, Teng Y, Li Y, Lin X, Guan M, Li Y, Cao X and Gao Y: miR-143-3p suppresses the progression of nasal squamous cell carcinoma by targeting Bcl-2 and IGF1R. Biochem Biophys Res Commun. 518:492–499. 2019.PubMed/NCBI View Article : Google Scholar

21 

Zaanan A, Calmel C, Henriques J, Svrcek M, Blons H, Desbois-Mouthon C, Merabtene F, Goumard C, Parc Y, Gayet B, et al: High IGF1R protein expression correlates with disease-free survival of patients with stage III colon cancer. Cell Oncol (Dordr). Dec 10. 2019.(Epub ahead of print). doi: 10.1007/s13402-019-00484-6. PubMed/NCBI View Article : Google Scholar

22 

Wang XH, Wu HY, Gao J, Wang XH, Gao TH and Zhang SF: IGF1R facilitates epithelial-mesenchymal transition and cancer stem cell properties in neuroblastoma via the STAT3/AKT axis. Cancer Manag Res. 11:5459–5472. 2019.PubMed/NCBI View Article : Google Scholar

23 

Ou JM, Lian WS, Qiu MK, Dai YX, Dong Q, Shen J, Dong P, Wang XF, Liu YB, Quan ZW and Fei ZW: Knockdown of IGF2R suppresses proliferation and induces apoptosis in hemangioma cells in vitro and in vivo. Int J Oncol. 45:1241–1249. 2014.PubMed/NCBI View Article : Google Scholar

24 

Liu ZQ, Fu WQ, Zhao S and Zhao X: Regulation of insulin-like growth factor 1 receptor signaling by microRNA-4458 in the development of lumbar disc degeneration. Am J Transl Res. 8:2309–2316. 2016.PubMed/NCBI View Article : Google Scholar

25 

Fu X, Zhai S and Yuan J: Interleukin-6 (IL-6) triggers the malignancy of hemangioma cells via activation of HIF-1α/VEGFA signals. Eur J Pharmacol. 41:82–89. 2018.PubMed/NCBI View Article : Google Scholar

26 

Qiu MK, Wang SQ, Pan C, Wang Y, Quan ZW, Liu YB and Ou JM: ROCK inhibition as a potential therapeutic target involved in apoptosis in hemangioma. Oncol Rep. 37:2987–2993. 2017.PubMed/NCBI View Article : Google Scholar

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

28 

Bandres E, Bitarte N, Arias F, Agorreta J, Fortes P, Agirre X, Zarate R, Diaz-Gonzalez JA, Ramirez N, Sola JJ, et al: microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells. Clin Cancer Res. 15:2281–2290. 2009.PubMed/NCBI View Article : Google Scholar

29 

Bao L, Wang L, Wei G, Wang Y, Wuyun G and Bo A: Role of microRNA-4458 in patients with non-small-cell lung cancer. Oncol Lett. 12:3958–3966. 2016.PubMed/NCBI View Article : Google Scholar

30 

Hoffman Y, Bublik DR, Ugalde AP, Elkon R, Biniashvili T, Agami R, Oren M and Pilpel Y: 3'UTR shortening potentiates MicroRNA-based repression of pro-differentiation genes in proliferating human cells. PLoS Genet. 12(e1005879)2016.PubMed/NCBI View Article : Google Scholar

31 

Zakraoui O, Marcinkiewicz C, Aloui Z, Othman H, Grépin R, Haoues M, Essafi M, Srairi-Abid N, Gasmi A, Karoui H, et al: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. Mol Carcinog. 56:18–37. 2017.PubMed/NCBI View Article : Google Scholar

32 

Wang S, Wang X, Wu Y and Han C: IGF-1R signaling is essential for the proliferation of cultured mouse spermatogonial stem cells by promoting the G2/M progression of the cell cycle. Stem Cells Dev. 24:471–483. 2015.PubMed/NCBI View Article : Google Scholar

33 

Zhang M, Liu J, Li M, Zhang S, Lu Y, Liang Y, Zhao K and Li Y: Insulin-like growth factor 1/insulin-like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells. Exp Ther Med. 16:1477–1482. 2018.PubMed/NCBI View Article : Google Scholar

34 

Ayub A, Yip WK and Seow HF: Dual treatments targeting IGF-1R, PI3K, mTORC or MEK synergize to inhibit cell growth, induce apoptosis, and arrest cell cycle at G1 phase in MDA-MB-231 cell line. Biomed Pharmacother. 75:40–50. 2015.PubMed/NCBI View Article : Google Scholar

35 

Li T, Zhao X, Mo Z, Huang W, Yan H, Ling Z and Ye Y: Formononetin promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells. Cell Physiol Biochem. 34:1351–1358. 2014.PubMed/NCBI View Article : Google Scholar

36 

Chen J, Duan Y, Zhang X, Ye Y, Ge B and Chen J: Genistein induces apoptosis by the inactivation of the IGF-1R/p-Akt signaling pathway in MCF-7 human breast cancer cells. Food Funct. 6:995–1000. 2015.PubMed/NCBI View Article : Google Scholar

37 

Dai Z, Wang L, Wang X, Zhao B, Zhao W, Bhardwaj SS, Ye J, Yin Z, Zhang J and Zhao S: Oxymatrine induces cell cycle arrest and apoptosis and suppresses the invasion of human glioblastoma cells through the EGFR/PI3K/Akt/mTOR signaling pathway and STAT3. Oncol Rep. 40:867–876. 2018.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wu M, Tang Y, Hu G, Yang C, Ye K and Liu X: miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma. Exp Ther Med 19: 3017-3023, 2020.
APA
Wu, M., Tang, Y., Hu, G., Yang, C., Ye, K., & Liu, X. (2020). miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma. Experimental and Therapeutic Medicine, 19, 3017-3023. https://doi.org/10.3892/etm.2020.8546
MLA
Wu, M., Tang, Y., Hu, G., Yang, C., Ye, K., Liu, X."miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma". Experimental and Therapeutic Medicine 19.4 (2020): 3017-3023.
Chicago
Wu, M., Tang, Y., Hu, G., Yang, C., Ye, K., Liu, X."miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma". Experimental and Therapeutic Medicine 19, no. 4 (2020): 3017-3023. https://doi.org/10.3892/etm.2020.8546
Copy and paste a formatted citation
x
Spandidos Publications style
Wu M, Tang Y, Hu G, Yang C, Ye K and Liu X: miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma. Exp Ther Med 19: 3017-3023, 2020.
APA
Wu, M., Tang, Y., Hu, G., Yang, C., Ye, K., & Liu, X. (2020). miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma. Experimental and Therapeutic Medicine, 19, 3017-3023. https://doi.org/10.3892/etm.2020.8546
MLA
Wu, M., Tang, Y., Hu, G., Yang, C., Ye, K., Liu, X."miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma". Experimental and Therapeutic Medicine 19.4 (2020): 3017-3023.
Chicago
Wu, M., Tang, Y., Hu, G., Yang, C., Ye, K., Liu, X."miR‑4458 directly targets IGF1R to inhibit cell proliferation and promote apoptosis in hemangioma". Experimental and Therapeutic Medicine 19, no. 4 (2020): 3017-3023. https://doi.org/10.3892/etm.2020.8546
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