Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2020 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2020 Volume 19 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey

  • Authors:
    • Xia Zhou
    • Hui Shi
    • Yuanhua Yang
    • Zuoqing Zhang
    • Zhenguo Zhai
    • Chen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shijingshan Teaching Hospital of Capital Medical University, Beijing Shijingshan Hospital, Beijing 100043, P.R. China, Department of Psychology, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100029, P.R. China, Department of Respiratory Medicine, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100029, P.R. China, Center of Respiratory Medicine, China‑Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases, Peking University Health Science Center, Beijing 100029, P.R. China
  • Pages: 3124-3132
    |
    Published online on: February 27, 2020
       https://doi.org/10.3892/etm.2020.8566
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Limited studies have focused on mental symptoms (anxiety and depression) and their impact on quality of life (QoL) in patients with pulmonary hypertension (PH). The objective of the present study was to assess the prevalence of anxiety and depression and their association with QoL in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic PH (CTEPH) in a Chinese population. Patients diagnosed with PH by right heart catheterization between March 2015 and February 2016 were recruited. QoL [short form 36 Health Survey Questionnaire (SF‑36)] and depression (Patient Health Questionnaire depression scale‑9) and anxiety (Generalized Anxiety Disorder‑7) were assessed at baseline. Patients were followed up every 3 months. A total of 36 patients with PAH and 62 patients with CTEPH were enrolled. According to the results of the clinical examination and the questionnaires for depression and anxiety, patients were divided into two groups: Group 1, with depression and/or anxiety (n=65, 66.3%) and group 2, without depression or anxiety (n=33, 33.7%). At baseline, the two groups did not differ in their hemodynamics. Patients with depression and/or anxiety (group 1) had a significantly lower score in all subscales of SF‑36 (P<0.05). The impairment of QoL significantly correlated with the severity of depression (P<0.001) and anxiety (P<0.05). During the follow‑up period, end‑point events (death or admission due to deterioration) occurred in 17 patients (17.3%); 8 patients (8.1%) were lost to follow‑up. The end‑point event‑free survival rate in group 2 was significantly higher than that in group 1. Multivariate logistic regression analysis suggested that the financial situation and right ventricular enlargement were influencing factors of depression and/or anxiety. In conclusion, in patients with PH from a Chinese population, anxiety and depression were frequently encountered and significantly correlated with QoL. The significant relevant factors influencing anxiety/depression were the financial situation and right ventricular enlargement and patients with depression had a worse prognosis than those without.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, et al: 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: The joint task force for the diagnosis and treatment of pulmonary hypertension of the European society of cardiology (ESC) and the European respiratory society (ERS): Endorsed by: Association for European paediatric and congenital cardiology (AEPC), international society for heart and lung transplantation (ISHLT). Eur Heart J. 37:67–119. 2016.PubMed/NCBI View Article : Google Scholar

2 

Matura LA, McDonough A and Carroll DL: Symptom prevalence, symptom severity, and health-related quality of life among young, middle, and older adults with pulmonary arterial hypertension. Am J Hosp Palliat Care. 33:214–221. 2016.PubMed/NCBI View Article : Google Scholar

3 

Heyworth IT, Hazell ML, Linehan MF and Frank TL: How do common chronic conditions affect health-related quality of life. Br J Gen Pract. 59:e353–e358. 2009.PubMed/NCBI View Article : Google Scholar

4 

Shafazand S, Goldstein MK, Doyle RL, Hlatky MA and Gould MK: Health-related quality of life in patients with pulmonary arterial hypertension. Chest. 126:1452–1459. 2004.PubMed/NCBI View Article : Google Scholar

5 

Batal O, Khatib OF, Bair N, Aboussouan LS and Minai OA: Sleep quality, depression, and quality of life in patients with pulmonary hypertension. Lung. 189:141–149. 2011.PubMed/NCBI View Article : Google Scholar

6 

Rubenfire M, Lippo G, Bodini BD, Blasi F, Allegra L and Bossone E: Evaluating health-related quality of life, work ability, and disability in pulmonary arterial hypertension: An unmet need. Chest. 136:597–603. 2009.PubMed/NCBI View Article : Google Scholar

7 

Chua R, Keogh AM, Byth K and O'Loughlin A: Comparison and validation of three measures of quality of life in patients with pulmonary hypertension. Intern Med J. 36:705–710. 2006.PubMed/NCBI View Article : Google Scholar

8 

Larisch A, Neeb C, de Zwaan M, Pabst C, Tiede H, Ghofrani A, Olsson K, Hoeper M and Kruse J: Mental distress and wish for psychosomatic treatment of patients with pulmonary hypertension. Psychother Psychosom Med Psychol. 64:384–389. 2014.(In German). PubMed/NCBI View Article : Google Scholar

9 

Löwe B, Gräfe K, Ufer C, Kroenke K, Grünig E, Herzog W and Borst MM: Anxiety and depression in patients with pulmonary hypertension. Psychosom Med. 66:831–836. 2004.PubMed/NCBI View Article : Google Scholar

10 

Harzheim D, Klose H, Pinado FP, Ehlken N, Nagel C, Fischer C, Ghofrani A, Rosenkranz S, Seyfarth HJ, Halank M, et al: Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Respir Res. 14(104)2013.PubMed/NCBI View Article : Google Scholar

11 

Halank M, Einsle F, Lehman S, Bremer H, Ewert R, Wilkens H, Meyer FJ, Grünig E, Seyfarth HJ, Kolditz M, et al: Exercise capacity affects quality of life in patients with pulmonary hypertension. Lung. 191:337–343. 2013.PubMed/NCBI View Article : Google Scholar

12 

Flattery MP, Pinson JM, Savage L and Salyer J: Living with pulmonary artery hypertension: Patients' experiences. Heart Lung. 34:99–107. 2005.PubMed/NCBI View Article : Google Scholar

13 

Cicero C, Franchi SM, Barreto AC and Lopes AA: Lack of tight association between quality of life and exercise capacity in pulmonary arterial hypertension. Arq Bras Cardiol. 99:876–885. 2012.(In English, Portuguese). PubMed/NCBI View Article : Google Scholar

14 

McCabe C, Bennett M, Doughty N, MacKenzie Ross R, Sharples L and Pepke-Zaba J: Patient-reported outcomes assessed by the CAMPHOR questionnaire predict clinical deterioration in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Chest. 144:522–530. 2013.PubMed/NCBI View Article : Google Scholar

15 

Nagel C, Prange F, Guth S, Herb J, Ehlken N, Fischer C, Reichenberger F, Rosenkranz S, Seyfarth HJ, Mayer E, et al: Exercise training improves exercise capacity and quality of life in patients with inoperable or residual chronic thromboembolic pulmonary hypertension. PLoS One. 7(e41603)2012.PubMed/NCBI View Article : Google Scholar

16 

Li L, Wang HM and Shen Y: Chinese SF-36 health survey: Translation, cultural adaptation, validation, and normalisation. J Epidemiol Community Health. 57:259–263. 2003.PubMed/NCBI View Article : Google Scholar

17 

Spitzer RL, Kroenke K, Williams JB and Löwe B: A brief measure for assessing generalized anxiety disorder: The GAD-7. Arch Intern Med. 166:1092–1097. 2006.PubMed/NCBI View Article : Google Scholar

18 

Kroenke K, Spitzer RL and Williams JB: The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med. 16:606–613. 2001.PubMed/NCBI View Article : Google Scholar

19 

Matura LA, McDonough A and Carroll DL: Health-related quality of life and psychological states in patients with pulmonary arterial hypertension. J Cardiovasc Nurs. 29:178–184. 2014.PubMed/NCBI View Article : Google Scholar

20 

McCollister DH, Beutz M, McLaughlin V, Rumsfeld J, Masoudi FA, Tripputi M, Yaeger T, Weintraub P and Badesch DB: Depressive symptoms in pulmonary arterial hypertension: Prevalence and association with functional status. Psychosomatics. 51:339–339.e8. 2010.PubMed/NCBI View Article : Google Scholar

21 

White J, Hopkins RO, Glissmeyer EW, Kitterman N and Elliott CG: Cognitive, emotional, and quality of life outcomes in patients with pulmonary arterial hypertension. Respir Res. 7(55)2006.PubMed/NCBI View Article : Google Scholar

22 

Buoli M, Caldiroli A, Serati M, Grassi S and Altamura AC: Sex steroids and major psychoses: Which role for DHEA-S and progesterone. Neuropsychobiology. 73:178–183. 2016.PubMed/NCBI View Article : Google Scholar

23 

Maurer J, Rebbapragada V, Borson S, Goldstein R, Kunik ME, Yohannes AM and Hanania NA: ACCP Workshop Panel on Anxiety and Depression in COPD: Anxiety and depression in COPD: Current understanding, unanswered questions, and research needs. Chest. 134 (4 Suppl):43S–56S. 2008.PubMed/NCBI View Article : Google Scholar

24 

Zhai Z, Zhou X, Zhang S, Xie W, Wan J, Kuang T, Yang Y, Huang H and Wang C: The impact and financial burden of pulmonary arterial hypertension on patients and caregivers: Results from a national survey. Medicine (Baltimore). 96(e6783)2017.PubMed/NCBI View Article : Google Scholar

25 

First MB, Spitzer RL, Gibbon M and Williams JBW: Structured clinical interview for DSM.IV.TR axis I disorders, research version, patient edition (SCID.I/P). New York: Biometrics Research, New York State Psychiatric Institute, 2002.

26 

Kam IW: Development of the bilingual (Chinese/English) SCID-I (Structured Clinical Interview for DSM-IV axis I disorder): A study of its reliability and validity in an in-patient population (Dissertation for Part III Examination of FHKCPsych) Hong Kong College of Psychiatrist, Hong Kong, 2000.

27 

Kawut SM, Horn EM, Berekashvili KK, Lederer DJ, Widlitz AC, Rosenzweig EB and Barst RJ: Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension. Pulm Pharmacol Ther. 19:370–374. 2006.PubMed/NCBI View Article : Google Scholar

28 

Sadoughi A, Roberts KE, Preston IR, Lai GP, McCollister DH, Farber HW and Hill NS: Use of selective serotonin reuptake inhibitors and outcomes in pulmonary arterial hypertension. Chest. 144:531–541. 2013.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Shi H, Yang Y, Zhang Z, Zhai Z and Wang C: Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey. Exp Ther Med 19: 3124-3132, 2020.
APA
Zhou, X., Shi, H., Yang, Y., Zhang, Z., Zhai, Z., & Wang, C. (2020). Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey. Experimental and Therapeutic Medicine, 19, 3124-3132. https://doi.org/10.3892/etm.2020.8566
MLA
Zhou, X., Shi, H., Yang, Y., Zhang, Z., Zhai, Z., Wang, C."Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey". Experimental and Therapeutic Medicine 19.4 (2020): 3124-3132.
Chicago
Zhou, X., Shi, H., Yang, Y., Zhang, Z., Zhai, Z., Wang, C."Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey". Experimental and Therapeutic Medicine 19, no. 4 (2020): 3124-3132. https://doi.org/10.3892/etm.2020.8566
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Shi H, Yang Y, Zhang Z, Zhai Z and Wang C: Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey. Exp Ther Med 19: 3124-3132, 2020.
APA
Zhou, X., Shi, H., Yang, Y., Zhang, Z., Zhai, Z., & Wang, C. (2020). Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey. Experimental and Therapeutic Medicine, 19, 3124-3132. https://doi.org/10.3892/etm.2020.8566
MLA
Zhou, X., Shi, H., Yang, Y., Zhang, Z., Zhai, Z., Wang, C."Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey". Experimental and Therapeutic Medicine 19.4 (2020): 3124-3132.
Chicago
Zhou, X., Shi, H., Yang, Y., Zhang, Z., Zhai, Z., Wang, C."Anxiety and depression in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: Results from a Chinese survey". Experimental and Therapeutic Medicine 19, no. 4 (2020): 3124-3132. https://doi.org/10.3892/etm.2020.8566
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team