Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2020 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2020 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells

  • Authors:
    • Meng Li
    • Yu‑Ting Bai
    • Kun Han
    • Xiao‑Dong Li
    • Jian Meng
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Central Hospital of Xuzhou, The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3337-3347
    |
    Published online on: March 6, 2020
       https://doi.org/10.3892/etm.2020.8578
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tongue squamous cell carcinoma (TSCC) is a common malignancy in oral cancer with a high mortality and morbidity. The ectodysplasin‑A receptor‑associated adaptor protein (EDARADD) is a death domain‑containing adaptor protein that interacts with the TNF family ligand ectodysplasin A receptor. It is known that EDARADD has an effect on the development of ectodermal derivative tissues, such as hair and teeth. EDARADD expression is also associated with the development of melanoma. However, the role of EDARADD in TSCC remains unknown. The aim of the present investigation was to explore whether EDARADD plays a role in the biological function of TSCC. Immunohistochemistry was used to measure the expression of EDARADD in TSCC tissues and adjacent normal tissue. EDARADD was knocked down in a TSCC cell line in vitro using a specific lentivirus. The expression level of the EDARADD gene and the efficacy of gene knockdown were evaluated by reverse transcription‑quantitative PCR, while EDARADD protein expression and the expression levels of Bcl‑2, MYC and NF‑κBp65 were determined by western blotting. Additionally, MTT assays, colony formation assays and apoptosis assays were carried out to examine the effect of EDARADD knockdown on the TSCC cells. A previous study showed that the majority of the TSCC tissues that were tested had high EDARADD expression. The expression of EDARADD both at mRNA and protein levels was significantly lower (P<0.01) after the gene was knocked down in the CAL27 cells compared with the level in control cells. Downregulation of EDARADD expression inhibited colony formation and proliferation and induced apoptosis of CAL27 cells when compared to control cells (P<0.01). Taken together, these results suggested that EDARADD may be actively involved in the progression of TSCC and that EDARADD may be a novel therapeutic target for the treatment of TSCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015.PubMed/NCBI View Article : Google Scholar

2 

Casiglia J and Woo SB: A comprehensive review of oral cancer. Gen Dent. 49:72–82. 2001.PubMed/NCBI

3 

Rosebush MS, Rao SK, Samant S, Gu W, Handorf CR, Pfeffer LM and Nosrat CA: Oral cancer: Enduring characteristics and emerging trends. J Mich Dent Assoc. 94:64–68. 2012.PubMed/NCBI

4 

Karatas OF, Oner M, Abay A and Diyapoglu A: MicroRNAs in human tongue squamous cell carcinoma: From pathogenesis to therapeutic implications. Oral Oncol. 67:124–130. 2017.PubMed/NCBI View Article : Google Scholar

5 

Xie N, Wang C, Liu X, Li R, Hou J, Chen X and Huang H: Tumor budding correlates with occult cervical lymph node metastasis and poor prognosis in clinical early-stage tongue squamous cell carcinoma. J Oral Pathol Med. 44:266–272. 2015.PubMed/NCBI View Article : Google Scholar

6 

Nóbrega TD, Queiroz SI, Santos EM, Costa AL, Pereira-Pinto L and de Souza LB: Clinicopathological evaluation and survival of patients with squamous cell carcinoma of the tongue. Med Oral Patol Oral Cir Bucal. 23:e579–e587. 2018.PubMed/NCBI View Article : Google Scholar

7 

Le Campion ACOV, Ribeiro CMB, Luiz RR, da Silva Júnior FF, Barros HCS, Dos Santos KCB, Ferreira SJ, Gonçalves LS and Ferreira SMS: Low survival rates of oral and oropharyngeal squamous cell carcinoma. Int J Dent. 2017(5815493)2017.PubMed/NCBI View Article : Google Scholar

8 

Shakeel Uz Zaman, Adeel M and Suhail A: Squamous cell carcinoma of oral tongue in young patients-a 10 years tertiary care experience. J Pak Med Assoc. 66:155–158. 2016.PubMed/NCBI

9 

Zhang YY, Wang DC, Su JZ, Jia LF, Peng X and Yu GY: Clinicopathological characteristics and outcomes of squamous cell carcinoma of the tongue in different age groups. Head Neck. 39:2276–2282. 2017.PubMed/NCBI View Article : Google Scholar

10 

Tang Q, Cheng B, Xie M, Chen Y, Zhao J, Zhou X and Chen L: Circadian clock gene bmal1 inhibits tumorigenesis and increases paclitaxel sensitivity in tongue squamous cell carcinoma. Cancer Res. 77:532–544. 2017.PubMed/NCBI View Article : Google Scholar

11 

Feng Z, Xu QS, Qin LZ, Li H and Han Z: Predicting radiotherapy necessity in tongue cancer using lymph Node Yield. J Oral Maxillofac Surg. 75:1062–1070. 2017.PubMed/NCBI View Article : Google Scholar

12 

Chen Y, Tian T, Mao MJ, Deng WY and Li H: CRBP-1 over-expression is associated with poor prognosis in tongue squamous cell carcinoma. BMC Cancer. 18(514)2018.PubMed/NCBI View Article : Google Scholar

13 

Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J and Daigo Y: Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer. Int J Oncol. 52:155–165. 2018.PubMed/NCBI View Article : Google Scholar

14 

Shih CH, Chang YJ, Huang WC, Jang TH, Kung HJ, Wang WC, Yang MH, Lin MC, Huang SF, Chou SW, et al: EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis. Oncogene. 36:6542–6554. 2017.PubMed/NCBI View Article : Google Scholar

15 

Li TK, Yin K, Chen Z, Bao Y and Zhang SX: MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genet Mol Res. 16(gmr16019327)2017.PubMed/NCBI View Article : Google Scholar

16 

Bal E, Baala L, Cluzeau C, El Kerch F, Ouldim K, Hadj-Rabia S, Bodemer C, Munnich A, Courtois G, Sefiani A and Smahi A: Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus. Hum Mutat. 28:703–709. 2007.PubMed/NCBI View Article : Google Scholar

17 

Podzus J, Kowalczyk-Quintas C, Schuepbach-Mallepell S, Willen L, Staehlin G, Vigolo M, Tardivel A, Headon D, Kirby N, Mikkola ML, et al: Ectodysplasin a in biological fluids and diagnosis of ectodermal dysplasia. J Dent Res. 96:217–224. 2017.PubMed/NCBI View Article : Google Scholar

18 

Bergendal B, Klar J, Stecksén-Blicks C, Norderyd J and Dahl N: Isolated oligodontia associated with mutations in EDARADD, AXIN2, MSX1, and PAX9 genes. Am J Med Genet A. 155A:1616–1622. 2011.PubMed/NCBI View Article : Google Scholar

19 

Arzoo PS, Klar J, Bergendal B, Norderyd J and Dahl N: WNT10A mutations account for ¼ of population-based isolated oligodontia and show phenotypic correlations. Am J Med Genet A. 164A:353–359. 2014.PubMed/NCBI View Article : Google Scholar

20 

Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK and Varambally S: UALCAN: A portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 19:649–658. 2017.PubMed/NCBI View Article : Google Scholar

21 

Boeker M, França F, Bronsert P and Schulz S: TNM-O: Ontology support for staging of malignant tumours. J Biomed Semantics. 7(64)2016.PubMed/NCBI View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

23 

Hashibe M, Brennan P, Chuang SC, Boccia S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, et al: Interaction between tobacco and alcohol use and the risk of head and neck cancer: Pooled analysis in the international head and neck cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev. 18:541–550. 2009.PubMed/NCBI View Article : Google Scholar

24 

Cancer Genome Atlas Network: Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature 517: 576-582, 2015.

25 

Tuna M, Amos CI and Mills GB: Genome-wide analysis of head and neck squamous cell carcinomas reveals HPV, TP53, smoking and alcohol-related allele-based acquired uniparental disomy genomic alterations. Neoplasia. 21:197–205. 2019.PubMed/NCBI View Article : Google Scholar

26 

Mohideen K, Krithika C, Jeddy N, Bharathi R, Thayumanavan B and Sankari SL: Meta-analysis on risk factors of squamous cell carcinoma of the tongue in young adults. J Oral Maxillofac Pathol. 23:450–457. 2019.PubMed/NCBI View Article : Google Scholar

27 

Jeon JH, Kim MG, Park JY, Lee JH, Kim MJ, Myoung H and Choi SW: Analysis of the outcome of young age tongue squamous cell carcinoma. Maxillofac Plast Reconstr Surg. 39(41)2017.PubMed/NCBI View Article : Google Scholar

28 

Zhou HY, Shu HY, Dai J, Li HC, Tang L, Wang HW and Ni B: Maternal genetic backgrounds contribute to the genetic susceptibility of tongue cancer patients in Hunan, central of China. Mitochondrial DNA A DNA Mapp Seq Anal. 29:347–352. 2018.PubMed/NCBI View Article : Google Scholar

29 

Haeggblom L, Ramqvist T, Tommasino M, Dalianis T and Näsman A: Time to change perspectives on HPV in oropharyngeal cancer. A systematic review of HPV prevalence per oropharyngeal sub-site the last 3 years. Papillomavirus Res. 4:1–11. 2017.PubMed/NCBI View Article : Google Scholar

30 

Ribeiro IP, Rodrigues JM, Mascarenhas A, Kosyakova N, Caramelo F, Liehr T, Melo JB and Carreira IM: Cytogenetic, genomic, and epigenetic characterization of the HSC-3 tongue cell line with lymph node metastasis. J Oral Sci. 60:70–81. 2018.PubMed/NCBI View Article : Google Scholar

31 

Bai Y, Cui X, Gao D, Wang Y, Wang B and Wang W: Golgi integral membrane protein 4 manipulates cellular proliferation, apoptosis, and cell cycle in human head and neck cancer. Biosci Rep: Aug 31, 2018 (Epub ahead of print). doi: 10.1042/BSR20180454.

32 

Chen G, Zhang Y, Liang J, Li W, Zhu Y, Zhang M, Wang C and Hou J: Deregulation of hexokinase II is associated with glycolysis, autophagy, and the epithelial-mesenchymal transition in tongue squamous cell carcinoma under hypoxia. Biomed Res Int. 2018(8480762)2018.PubMed/NCBI View Article : Google Scholar

33 

Ramos GO, Meyer GL, Visioli F, Manoela MD and Oliveira MG: Carcinoma cuniculatum in the tongue of a patient with oral lichen planus: Unusual presentation. Indian J Dent Res. 29:525–528. 2018.PubMed/NCBI View Article : Google Scholar

34 

Vigneswaran N and Williams MD: Epidemiologic trends in head and neck cancer and aids in diagnosis. Oral Maxillofac Surg Clin North Am. 26:123–141. 2014.PubMed/NCBI View Article : Google Scholar

35 

Zhang B, Li KY, Chen HY, Pan SD, Jiang LC, Wu YP and Liu SW: Spindle and kinetochore associated complex subunit 1 regulates the proliferation of oral adenosquamous carcinoma CAL-27 cells in vitro. Cancer Cell Int. 13(83)2013.PubMed/NCBI View Article : Google Scholar

36 

Xu S, Ma D, Zhuang R, Sun W, Liu Y, Wen J and Cui L: DJ-1 is upregulated in oral squamous cell carcinoma and promotes oral cancer cell proliferation and invasion. J Cancer. 7:1020–1028. 2016.PubMed/NCBI View Article : Google Scholar

37 

Kumar A, Eby MT, Sinha S, Jasmin A and Chaudhary PM: The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. J Biol Chem. 276:2668–2677. 2001.PubMed/NCBI View Article : Google Scholar

38 

Vial J, Royet A, Cassier P, Tortereau A, Dinvaut S, Maillet D, Gratadou-Hupon L, Creveaux M, Sadier A, Tondeur G, et al: The ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death. Cell Death Differ. 26:443–454. 2019.PubMed/NCBI View Article : Google Scholar

39 

Chen YT, Liu HC, Han D, Liu Y and Feng HL: Association between EDAR polymorphisms and non-syndromic tooth agenesis in the chinese han population. Chin J Dent Res. 20:153–159. 2017.PubMed/NCBI View Article : Google Scholar

40 

Suda N, Bazar A, Bold O, Jigjid B, Garidkhuu A, Ganburged G and Moriyama K: A mongolian patient with hypohidrotic ectodermal dysplasia with a novel P121S variant in EDARADD. Orthod Craniofac Res. 13:114–117. 2010.PubMed/NCBI View Article : Google Scholar

41 

Chassaing N, Cluzeau C, Bal E, Guigue P, Vincent MC, Viot G, Ginisty D, Munnich A, Smahi A and Calvas P: Mutations in EDARADD account for a small proportion of hypohidrotic ectodermal dysplasia cases. Br J Dermatol. 162:1044–1048. 2010.PubMed/NCBI View Article : Google Scholar

42 

Masui Y, Farooq M, Sato N, Fujimoto A, Fujikawa H, Ito M and Shimomura Y: A missense mutation in the death domain of EDAR abolishes the interaction with EDARADD and underlies hypohidrotic ectodermal dysplasia. Dermatology. 223:74–79. 2011.PubMed/NCBI View Article : Google Scholar

43 

Wohlfart S, Söder S, Smahi A and Schneider H: A novel missense mutation in the gene EDARADD associated with an unusual phenotype of hypohidrotic ectodermal dysplasia. Am J Med Genet A. 170A:249–253. 2016.PubMed/NCBI View Article : Google Scholar

44 

Sadier A, Lambert E, Chevret P, Décimo D, Sémon M, Tohmé M, Ruggiero F, Ohlmann T, Pantalacci S and Laudet V: Tinkering signaling pathways by gain and loss of protein isoforms: The case of the EDA pathway regulator EDARADD. BMC Evol Biol. 15(129)2015.PubMed/NCBI View Article : Google Scholar

45 

Courtois G and Gilmore TD: Mutations in the NF-kappaB signaling pathway: Implications for human disease. Oncogene. 25:6831–6843. 2006.PubMed/NCBI View Article : Google Scholar

46 

Wang Y, Lin Z, Sun L, Fan S, Huang Z, Zhang D, Yang Z, Li J and Chen W: Akt/Ezrin Tyr353/NF-κB pathway regulates EGF-induced EMT and metastasis in tongue squamous cell carcinoma. Br J Cancer. 110:695–705. 2014.PubMed/NCBI View Article : Google Scholar

47 

He HJ, Bing H and Liu G: TSR2 induces laryngeal cancer cell apoptosis through inhibiting NF-κB signaling pathway. Laryngoscope. 128:E130–E134. 2018.PubMed/NCBI View Article : Google Scholar

48 

Shishodia S and Aggarwal BB: Nuclear factor-kappaB: A friend or a foe in cancer? Biochem Pharmacol. 68:1071–1680. 2004.PubMed/NCBI View Article : Google Scholar

49 

Charbonneau B, Block MS, Bamlet WR, Vierkant RA, Kalli KR, Fogarty Z, Rider DN, Sellers TA, Tworoger SS, Poole E, et al: Risk of ovarian cancer and the NF-κB pathway: Genetic association with IL1A and TNFSF10. Cancer Res. 74:852–861. 2014.PubMed/NCBI View Article : Google Scholar

50 

Hoesel B and Schmid JA: The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 12(86)2013.PubMed/NCBI View Article : Google Scholar

51 

Zeligs KP, Neuman MK and Annunziata CM: Molecular pathways: The balance between cancer and the immune system challenges the therapeutic specificity of targeting nuclear factor-κB signaling for cancer treatment. Clin Cancer Res. 22:4302–4308. 2016.PubMed/NCBI View Article : Google Scholar

52 

Zeng S, Zhao X, Xu LS, Yang D, Chen L and Xu MH: Apoptosis induction effect of Apocynum venetum polyphenol on human U87 glioma cells via NF-κB pathway. Future Oncol. 15:3723–3738. 2019.PubMed/NCBI View Article : Google Scholar

53 

Giridharan S and Srinivasan M: Mechanisms of NF-κB p65 and strategies for therapeutic manipulation. J Inflamm Res. 11:407–419. 2018.PubMed/NCBI View Article : Google Scholar

54 

Wei H, Li J, Li Y and Song J: MicroRNA-451 inhibits inflammation and proliferation of glomerular mesangial cells through down-regulating PSMD11 and NF-κB p65. Biosci Rep. 39(BSR20191455)2019.PubMed/NCBI View Article : Google Scholar

55 

Cai L, Li CM, Chen WN, Qiu YY, Guo YL and Li R: Penta-acetyl geniposide induces apoptosis of fibroblast-like synoviocytes from adjuvant-induced arthritis rats in vitro, associated with inhibition of NF-κB activation. Pharmacol Rep. 71:1006–1013. 2019.PubMed/NCBI View Article : Google Scholar

56 

Adams JM and Cory S: The Bcl-2 protein family: Arbiters of cell survival. Science. 281:1322–1326. 1998.PubMed/NCBI View Article : Google Scholar

57 

Zhao M, Zhang Y, Li J, Li X, Cheng N, Wang Q, Cai W, Zhao C, He Y, Chang J and Zhou C: Histone deacetylation, as opposed to promoter methylation, results in epigenetic BIM silencing and resistance to EGFR TKI in NSCLC. Oncol Lett. 15:1089–1096. 2018.PubMed/NCBI View Article : Google Scholar

58 

Dang CV: c-Myc target genes involved in cell growth, apoptosis, and metabolism. Mol Cell Biol. 19:1–11. 1999.PubMed/NCBI View Article : Google Scholar

59 

Hao YH, Lafita-Navarro MC, Zacharias L, Borenstein-Auerbach N, Kim M, Barnes S, Kim J, Shay J, DeBerardinis RJ and Conacci-Sorrell M: Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation. Cell Commun Signal. 17(129)2019.PubMed/NCBI View Article : Google Scholar

60 

Farria AT, Mustachio LM, Akdemir ZHC and Dent SYR: GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways. Oncotarget. 10:5847–5858. 2019.PubMed/NCBI View Article : Google Scholar

61 

Jiang H, Li Y, Li J, Zhang X, Niu G, Chen S and Yao S: Long noncoding RNA LSINCT5 promotes endometrial carcinoma cell proliferation, cycle, and invasion by promoting the Wnt/β-catenin signaling pathway via HMGA2. Ther Adv Med Oncol. 11(1758835919874649)2019.PubMed/NCBI View Article : Google Scholar

62 

Ma JX, Sun YL, Yu Y, Zhang J, Wu HY and Yu XF: Triptolide enhances the sensitivity of pancreatic cancer PANC-1 cells to gemcitabine by inhibiting TLR4/NF-κB signaling. Am J Transl Res. 11:3750–3760. 2019.PubMed/NCBI

63 

Tanaka K, Tanaka T, Nakano T, Hozumi Y, Yanagida M, Araki Y, Iwazaki K, Takagi M and Goto K: Knockdown of DEAD-box RNA helicase DDX5 selectively attenuates serine 311 phosphorylation of NF-κB p65 subunit and expression level of anti-apoptotic factor Bcl-2. Cell Signal. 65(109428)2019.PubMed/NCBI View Article : Google Scholar

64 

Wang M, Zeng X, Li S, Sun Z, Yu J, Chen C, Shen X, Pan W and Luo H: A novel tanshinone analog exerts anti-cancer effects in prostate cancer by inducing cell apoptosis, arresting cell cycle at G2 phase and blocking metastatic ability. Int J Mol Sci. 20(E4459)2019.PubMed/NCBI View Article : Google Scholar

65 

Zhang S, Ma H, Zhang D, Xie S, Wang W, Li Q, Lin Z and Wang Y: LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin/Fak/Src signaling. Cell Death Dis. 9(742)2018.PubMed/NCBI View Article : Google Scholar

66 

Zhao L, Li P, Zhao L, Wang M, Tong D, Meng Z, Zhang Q, Li Q and Zhang F: Expression and clinical value of PD-L1 which is regulated by BRD4 in tongue squamous cell carcinoma. J Cell Biochem. 121:1855–1869. 2020.PubMed/NCBI View Article : Google Scholar

67 

Huang L, Song F, Sun H, Zhang L and Huang C: IRX5 promotes NF-κB signalling to increase proliferation, migration and invasion via OPN in tongue squamous cell carcinoma. J Cell Mol Med 2018 (Epub ahead of print).

68 

Yang N, Gao J, Cheng X, Hou C, Yang Y, Qiu Y, Xu M, Zhang Y and Huang S: Grape seed proanthocyanidins inhibit the proliferation, migration and invasion of tongue squamous cell carcinoma cells through suppressing the protein kinase B/nuclear factor-κB signaling pathway. Int J Mol Med. 40:1881–1888. 2017.PubMed/NCBI View Article : Google Scholar

69 

Shi Y, Wu WZ, Huo A, Zhou W and Jin XH: Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells. Oncol Lett. 14:2852–2858. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li M, Bai YT, Han K, Li XD and Meng J: Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells. Exp Ther Med 19: 3337-3347, 2020.
APA
Li, M., Bai, Y., Han, K., Li, X., & Meng, J. (2020). Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells. Experimental and Therapeutic Medicine, 19, 3337-3347. https://doi.org/10.3892/etm.2020.8578
MLA
Li, M., Bai, Y., Han, K., Li, X., Meng, J."Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells". Experimental and Therapeutic Medicine 19.5 (2020): 3337-3347.
Chicago
Li, M., Bai, Y., Han, K., Li, X., Meng, J."Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3337-3347. https://doi.org/10.3892/etm.2020.8578
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Bai YT, Han K, Li XD and Meng J: Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells. Exp Ther Med 19: 3337-3347, 2020.
APA
Li, M., Bai, Y., Han, K., Li, X., & Meng, J. (2020). Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells. Experimental and Therapeutic Medicine, 19, 3337-3347. https://doi.org/10.3892/etm.2020.8578
MLA
Li, M., Bai, Y., Han, K., Li, X., Meng, J."Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells". Experimental and Therapeutic Medicine 19.5 (2020): 3337-3347.
Chicago
Li, M., Bai, Y., Han, K., Li, X., Meng, J."Knockdown of ectodysplasin‑A receptor‑associated adaptor protein exerts a tumor‑suppressive effect in tongue squamous cell carcinoma cells". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3337-3347. https://doi.org/10.3892/etm.2020.8578
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team