|
1
|
Osthoff M, Jenkins C and Leuppi J: Chronic
obstructive pulmonary disease-a treatable disease. Swiss Med Wkly.
143(w13777)2013.PubMed/NCBI View Article : Google Scholar
|
|
2
|
Vestbo J, Hurd SS, Agusti AG, Jones PW,
Vogelmeier C, Anzueto A, Barns PJ, Fabbri LM, Martinez FJ,
Nishimura M, et al: Global strategy for the diagnosis, management,
and prevention of chronic obstructive pulmonary disease: GOLD
executive summary. Am J Respir Crit Care Med. 187:347–365.
2013.PubMed/NCBI View Article : Google Scholar
|
|
3
|
Kirkham P and Rahman I: Oxidative stress
in asthma and COPD: Antioxidants as a therapeutic strategy.
Pharmacol Ther. 111:476–494. 2006.PubMed/NCBI View Article : Google Scholar
|
|
4
|
Barnes P: Inhaled corticosteroids are
beneficial in chronic obstructive pulmonary disease. Am J Respir
Crit Care Med. 161:341–342; discussion 344. 2000.PubMed/NCBI View Article : Google Scholar
|
|
5
|
Culpitt SV, Maziak W, Loukidis S,
Nightingale JA, Matthews JL and Barnes PJ: Effect of high dose
inhaled steroid on cells, cytokines and proteases in induced sputum
in chronic obstructive pulmonary disease. Am J Respir Crit Care
Med. 160:1635–1639. 1999.PubMed/NCBI View Article : Google Scholar
|
|
6
|
Hattotuwa KL, Gizycki MJ, Ansari TW,
Jeffery PK and Barnes NC: The effects of inhaled fluticasone on
airway inflammation in chronic obstructive pulmonary disease. Am J
Respir Crit Care Med. 165:1592–1596. 2002.PubMed/NCBI View Article : Google Scholar
|
|
7
|
Ford PA, Durham AL, Russell RE, Gordon F,
Adcock IM and Barnes PJ: Treatment effects of low-dose theophylline
combined with an inhaled corticosteroid in COPD. Chest.
137:1338–1644. 2010.PubMed/NCBI View Article : Google Scholar
|
|
8
|
Kobayashi Y, Wada H, Rossios C, Takagi D,
Charron C, Barnes PJ and Ito K: A novel macrolide/fluoroketolide,
solithromycin (CEM-101), reverses corticosteroid insensitivity via
phosphoinositide 3-kinase pathway inhibition. Br J Pharmacol.
169:1024–1034. 2013.PubMed/NCBI View Article : Google Scholar
|
|
9
|
To Y, Ito K, Kizawa Y, Failla M, Ito M,
Kusama T, Elliott WM, Hogg JC, Adcock IM and Barnes PJ: Targeting
phosphoinositide-3-kinase-delta with theophylline reverses
corticosteroid insensitivity in chronic obstructive pulmonary
disease. Am J Respir Crit Care Med. 182:897–904. 2010.PubMed/NCBI View Article : Google Scholar
|
|
10
|
Barnes PJ, Adcock IM and Ito K: Histone
acetylation and deacetylation: Importance in inflammatory lung
diseases. Eur Respir J. 25:552–563. 2005.PubMed/NCBI View Article : Google Scholar
|
|
11
|
Rahman I and Adcock IM: Oxidative stress
and redox regulation of lung inflammation in COPD. Eur Respir J.
28:219–242. 2006.PubMed/NCBI View Article : Google Scholar
|
|
12
|
Sun X, Li Q, Gong Y, Ren L, Wan H and Deng
W: Low-dose theophylline restores corticosteroid responsiveness in
rats with smoke-induced airway inflammation. Can J Physiol
Pharmacol. 90:895–902. 2012.PubMed/NCBI View Article : Google Scholar
|
|
13
|
De Ruijter AJ, van Gennip AH, Caron HN,
Kemp S and van Kuilenburg AB: Histone deacetylases (HDACs):
Characterization of the classical HDAC family. Biochem J.
370:737–749. 2003.PubMed/NCBI View Article : Google Scholar
|
|
14
|
Barnes PJ and Adcock IM: Glucocorticoid
resistance in inflammatory diseases. Lancet. 373:1905–1917.
2000.
|
|
15
|
Ito K, Caramori G and Adcock IM:
Therapeutic potential of phosphatidylinositol 3-kinase inhibitors
in inflammatory respiratory disease. J Pharmacol Exp Ther. 321:1–8.
2007.PubMed/NCBI View Article : Google Scholar
|
|
16
|
Ito K, Lim S, Caramori G, Chung KF, Barns
PJ and Adcock IM: Cigarette smoking reduces histone deacetylase 2
expression, enhances cytokine expression, and inhibits
glucocorticoid actions in alveolar macrophages. FASEB J.
15:1110–1112. 2001.PubMed/NCBI
|
|
17
|
Barned PJ: Cellular and molecular
mechanisms of asthma and COPD. Clin Sci (Lond). 131:1541–1558.
2017.PubMed/NCBI View Article : Google Scholar
|
|
18
|
Kok K, Geering B and Vanhaesebroeck B:
Regulation of phosphoinositide 3-kinase expression in health and
disease. Trends Biochem Sci. 34:115–127. 2009.PubMed/NCBI View Article : Google Scholar
|
|
19
|
Marwick JA, Caramori G, Casolari P,
Mazzoni F, Kirkham PA, Adcock IM, Chung KF and Papi A: A role for
phosphoinositol 3-kinase delta in the impairment of glucocorticoid
responsiveness in patients with chronic obstructive pulmonary
disease. J Allergy Clin Immunol. 125:1146–1153. 2010.PubMed/NCBI View Article : Google Scholar
|
|
20
|
Ichiyama T, Hasegawa S, Matsubara T,
Hayashi T and Furukawa S: Theophylline inhibits NF-kappa B
activation and I kappa B alpha degradation in human pulmonary
epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 364:558–561.
2001.PubMed/NCBI View Article : Google Scholar
|
|
21
|
Cosio BG, Tsaprouni L, Ito K, Jazrawi E,
Adcock IM and Barns PJ: Theophylline restores histone deacetylase
activity and steroid responses in COPD macrophages. J Exp Med.
200:689–695. 2004.PubMed/NCBI View Article : Google Scholar
|
|
22
|
Cosio BG, Iglesias A, Rios A, Noguera A,
Sala E, Ito K, Barns PJ and Agusti A: Low-dose theophylline
enhances the anti-inflammatory effects of steroids during
exacerbations of COPD. Thorax. 64:424–429. 2009.PubMed/NCBI View Article : Google Scholar
|
|
23
|
Li M, Zhong X, He Z, Wen M, Li J, Peng X,
Liu G, Deng J, Zhang J and Bai J: Effect of erythromycin on
cigarette-induced histone deacetylase protein expression and
nuclear factor-κB activity in human macrophages in vitro. Int
Immunopharmacol. 12:643–650. 2012.PubMed/NCBI View Article : Google Scholar
|
|
24
|
Sun XJ, Li ZH, Zhang Y, Zhou G, Zhang JQ,
Deng JM, Bai J, Liu GN, Li MH, MacNee W, et al: Combination of
erythromycin and dexamethasone improves corticosteroid sensitivity
induced by cigarette smoke extract through inhibition of PI3K-δ/Akt
pathway and increased GR expression. Am J Physiol Lung Cell Mol
Physiol. 309:L139–L146. 2015.PubMed/NCBI View Article : Google Scholar
|
|
25
|
Mercado N, To Y, Ito K and Barnes PJ:
Nortriptyline reverses corticosteroid insensitivity by inhibition
of phosphoinositide-3-kinase-δ. J Pharmacol Exp Ther. 337:465–470.
2011.PubMed/NCBI View Article : Google Scholar
|
|
26
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C (T)) method. Methods. 25:402–408.
2001.PubMed/NCBI View Article : Google Scholar
|
|
27
|
Culpitt SV, Rogers DF, Shah P, De Matos C,
Russell RE, Donnelly LE and Barnes PJ: Impaired inhibition by
dexamethasone of cytokine release by alveolar macrophages from
patients with chronic obstructive pulmonary disease. Am J Respir
Crit Care Med. 167:24–31. 2003.PubMed/NCBI View Article : Google Scholar
|
|
28
|
Szulakowski P, Crowther AJ, Jimenez LA,
Donaldson K, Mayer R, Leonard TB, Macnee W and Drost EM: The effect
of smoking on the transcriptional regulation of lung inflammation
in patients with chronic obstructive pulmonary disease. Am J Respir
Crit Care Med. 174:41–50. 2006.PubMed/NCBI View Article : Google Scholar
|
|
29
|
Ngkelo A: The role of GSK3β in regulating
corticosteroid function under conditions of oxidative stress in
chronic obstructive pulmonary disease. Imperial College 2012.
|
|
30
|
Ortiz JL, Milara J, Lluch J, De Diego A,
Sanz C and Cortijo J: Phosphodiesterase-4 inhibition improves
corticosteroid insensitivity in pulmonary endothelial cells under
oxidative stress. Allergy. 68:64–73. 2013.PubMed/NCBI View Article : Google Scholar
|
|
31
|
Hennessy BT, Smith DL, Ram PT, Lu Y and
Mills GB: Exploiting the PI3K/AKT pathway for cancer drug
discovery. Nat Rev Drug Discov. 4:988–1004. 2005.PubMed/NCBI View Article : Google Scholar
|
