Neferine prevents ultraviolet radiation‑induced skin photoaging
- Abidullah Khan
- Hongliang Bai
- Amin Khan
- Zhuanli Bai
Affiliations: Department of Burn and Plastic Surgery, First Affiliated Hospital of Xi'an Jiaotong University, School of Medicine, Xi'an, Shaanxi 710061, P.R. China, Department of Chemistry, University of Science and Technology, Bannu, Khyber Pakhtunkhwa 28100, Pakistan
- Published online on: March 9, 2020 https://doi.org/10.3892/etm.2020.8587
Copyright: © Khan
et al. This is an open access article distributed under the
terms of Creative
Commons Attribution License.
Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
The aim of the present study was to evaluate the anti‑photoaging effect of neferine upon exposure of mice to ultraviolet (UV) radiation. An in vivo photoaging model was established by repeatedly exposing mouse dorsal skin to UV‑A and UV‑B radiation for 12 weeks. Through skin photographs, hematoxylin and eosin staining, Masson's trichrome staining, and scanning and transmission electron microscopy, skin wrinkles, epidermal thickness and dermal collagen were analyzed in the UV‑irradiated mouse skin. Furthermore, the levels of endogenous antioxidants, namely superoxide dismutase (SOD) and glutathione peroxidase (GPx), were measured to determine the extent of UV‑induced oxidative stress that was associated with photoaging. The results demonstrated that the topical application of neferine following UV irradiation reduced oxidative stress by increasing SOD and GPx activities, and attenuated the photoaging process. Histological and ultrastructural examination revealed that neferine delayed skin wrinkle formation by inhibiting epidermal hypertrophy and collagen loss and degradation. In conclusion, the results of the present study indicated that neferine effectively prevents UV‑induced skin photoaging and photodamage.