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lncRNA MIAT promotes cell invasion and migration in esophageal cancer

  • Authors:
    • Weiguo Zhang
    • Qiang Chen
    • Caipeng Lei
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    Affiliations: Department of Surgical Oncology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3267-3274
    |
    Published online on: March 9, 2020
       https://doi.org/10.3892/etm.2020.8588
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Abstract

Long non‑coding RNAs (lncRNAs) serve crucial roles in carcinogenesis. Myocardial infarction‑associated transcript (MIAT), originally isolated as a candidate gene for myocardial infarction, has been revealed to serve as an oncogene in chronic lymphocytic leukaemias and neuroendocrine prostate cancer. However, little is known about its expression pattern, biological function and underlying mechanism in esophageal cancer. Cell lines of esophageal cancer were used in the current study. The results of the present study revealed that MIAT knockdown decreased cell viability, migration, invasion and cell cycle arrest in the G1 phase. Mechanistic assessment revealed that MIAT interacts with histone methyltransferase mixed‑lineage leukemia (MLL). The relative proteins expressions were measured by western blotting assay. MIAT knockdown suppressed cell invasion and migration by regulation MMP‑2/9 protein expressions. The results of the current study indicated that MIAT expression was associated with esophageal cancer and may serve as a critical target in the progression and metastasis in esophageal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Chen Q and Lei C: lncRNA MIAT promotes cell invasion and migration in esophageal cancer. Exp Ther Med 19: 3267-3274, 2020.
APA
Zhang, W., Chen, Q., & Lei, C. (2020). lncRNA MIAT promotes cell invasion and migration in esophageal cancer. Experimental and Therapeutic Medicine, 19, 3267-3274. https://doi.org/10.3892/etm.2020.8588
MLA
Zhang, W., Chen, Q., Lei, C."lncRNA MIAT promotes cell invasion and migration in esophageal cancer". Experimental and Therapeutic Medicine 19.5 (2020): 3267-3274.
Chicago
Zhang, W., Chen, Q., Lei, C."lncRNA MIAT promotes cell invasion and migration in esophageal cancer". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3267-3274. https://doi.org/10.3892/etm.2020.8588
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Chen Q and Lei C: lncRNA MIAT promotes cell invasion and migration in esophageal cancer. Exp Ther Med 19: 3267-3274, 2020.
APA
Zhang, W., Chen, Q., & Lei, C. (2020). lncRNA MIAT promotes cell invasion and migration in esophageal cancer. Experimental and Therapeutic Medicine, 19, 3267-3274. https://doi.org/10.3892/etm.2020.8588
MLA
Zhang, W., Chen, Q., Lei, C."lncRNA MIAT promotes cell invasion and migration in esophageal cancer". Experimental and Therapeutic Medicine 19.5 (2020): 3267-3274.
Chicago
Zhang, W., Chen, Q., Lei, C."lncRNA MIAT promotes cell invasion and migration in esophageal cancer". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3267-3274. https://doi.org/10.3892/etm.2020.8588
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