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Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis

  • Authors:
    • Sen Tao
    • Hong Zhang
    • Qiang Zhao
    • Huaien Bu
    • Hongwu Wang
    • Hui Guo
  • View Affiliations / Copyright

    Affiliations: Department of Hepatology, The First Hospital Affiliated to Tianjin TCM University, Tianjin 300380, P.R. China, Department of Prevention, Tianjin Second People's Hospital, Tianjin 300192, P.R. China, Institute of Medical Engineering and Health Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P.R. China
    Copyright: © Tao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3419-3424
    |
    Published online on: March 12, 2020
       https://doi.org/10.3892/etm.2020.8601
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Abstract

Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis were investigated. Patients with liver diseases (n=635) treated in The Sixth People's Hospital of Qingdao City from March 2015 to January 2018 were selected, among which 80 cases diagnosed with autoimmune hepatitis were included into observation group, and 80 healthy cases were included into control group. Patients with autoimmune hepatitis were further divided into normal 25‑hydroxyvitamin D [25‑(OH) D] group (n=40) and abnormal 25‑(OH) D group (n=40) according to the level of 25‑(OH) D, and divided into normal liver function group (n=40) and abnormal liver function group (n=40). 25‑(OH) D, liver function, inflammatory factors, oxidative stress level and T cell subsets were compared. In the observation group, levels of 25‑(OH) D, superoxide dismutase (SOD), total antioxidant capacity, and T cell subsets were lower than those in the control group (P<0.05), while levels of total bilirubin (TBIL), indirect BIL (IBIL), direct BIL (DBIL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), inflammatory factors and malondialdehyde (MDA) were higher than those in the control group (P<0.05). In the normal 25‑(OH) D group, levels of inflammatory factors and oxidative stress factor were lower than those in the abnormal 25‑(OH) D group (P<0.05), while the SOD level, total antioxidant capacity and T cell subset counts were higher than those in the abnormal 25‑(OH) D group (P<0.05). Moreover, the 25‑(OH) D level in patients with autoimmune hepatitis was negatively correlated with hs‑CRP, tumor necrosis factor‑α (TNF‑α), ALT and MDA, but positively correlated with CD3+ and CD4+ counts, SOD and total antioxidant capacity. Patients with autoimmune hepatitis, especially those with decreased level of vitamin D, are more prone to enhanced inflammatory and stress responses, decreased levels of T cell subsets and decline in immunity.
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1 

Lee WS, Jalaludin MY, Wong SY, Ong SY, Foo HW and Ng RT: Vitamin D non-sufficiency is prevalent in children with chronic liver disease in a tropical country. Pediatr Neonatol. 60:12–18. 2019.PubMed/NCBI View Article : Google Scholar

2 

Czaja AJ: Epigenetic changes and their implications in autoimmune hepatitis. Eur J Clin Invest. 48:899–912. 2018.PubMed/NCBI View Article : Google Scholar

3 

Ferrari SM, Fallahi P, Antonelli A and Benvenga S: Environmental issues in thyroid diseases. Front Endocrinol (Lausanne). 8:50–58. 2017.PubMed/NCBI View Article : Google Scholar

4 

Arooj M, Malik A, Basit A, Husain Qazi M, Asif M, Sarwar Jamal M, Mostafa Mahmoud M, Choudhry H, Natesan Pushparaj .Rasool M: Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy. Bioinformation. 12:131–134. 2016.PubMed/NCBI View Article : Google Scholar

5 

Montano-Loza AJ, Thandassery RB and Czaja AJ: Targeting hepatic fibrosis in autoimmune hepatitis. Dig Dis Sci. 61:3118–3139. 2016.PubMed/NCBI View Article : Google Scholar

6 

Kaji H: Treatment for hepatic osteodystrophy. Clin Calcium. 25:1689–1694. 2015.(In Japanese). PubMed/NCBI

7 

Ahmed SZ, Jaleel A, Hameed K, Qazi S and Suleman A: Does vitamin D deficiency contribute to the severity of asthma in children and adults? J Ayub Med Coll Abbottabad. 27:458–463. 2015.PubMed/NCBI

8 

Purohit T and Cappell MS: Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy. World J Hepatol. 7:926–941. 2015.PubMed/NCBI View Article : Google Scholar

9 

Reiter FP, Hohenester S, Nagel JM, Wimmer R, Artmann R, Wottke L, Makeschin MC, Mayr D, Rust C, Trauner M, et al: 1,25-(OH)2-vitamin D3 prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4(-/-) model. Biochem Biophys Res Commun. 459:227–233. 2015.PubMed/NCBI View Article : Google Scholar

10 

Beyazit Y, Kocak E, Tanoglu A and Kekilli M: Oxidative stress might play a role in low serum vitamin D associated liver fibrosis among patients with autoimmune hepatitis. Dig Dis Sci. 60:1106–1108. 2015.PubMed/NCBI View Article : Google Scholar

11 

Chen EQ, Shi Y and Tang H: New insight of vitamin D in chronic liver diseases. Hepatobiliary Pancreat Dis Int. 13:580–585. 2014.PubMed/NCBI View Article : Google Scholar

12 

Petta S, Grimaudo S, Tripodo C, Cabibi D, Calvaruso M, Di Cristina A, Guarnotta C, Macaluso FS, Minissale MG, Marchesini G, et al: The hepatic expression of vitamin D receptor is inversely associated with the severity of liver damage in genotype 1 chronic hepatitis C patients. J Clin Endocrinol Metab. 100:193–200. 2015.PubMed/NCBI View Article : Google Scholar

13 

Boglione L, Cusato J, De Nicolò A, Cariti G, Di Perri G and D'Avolio A: Role of CYP27B1+2838 promoter polymorphism in the treatment of chronic hepatitis B HBeAg negative with PEG-interferon. J Viral Hepat. 22:318–327. 2015.PubMed/NCBI View Article : Google Scholar

14 

Efe C, Kav T, Aydin C, Cengiz M, Imga NN, Purnak T, Smyk DS, Torgutalp M, Turhan T, Ozenirler S, et al: Low serum vitamin D levels are associated with severe histological features and poor response to therapy in patients with autoimmune hepatitis. Dig Dis Sci. 59:3035–3042. 2014.PubMed/NCBI View Article : Google Scholar

15 

Borella E, Nesher G, Israeli E and Shoenfeld Y: Vitamin D: A new anti-infective agent? Ann N Y Acad Sci. 1317:76–83. 2014.PubMed/NCBI View Article : Google Scholar

16 

Abdel-Rehim AS, Sheha DS and Mohamed NA: Vitamin D level among Egyptian patients with chronic spontaneous urticaria and its relation to severity of the disease. Egypt J Immunol. 21:85–90. 2014.PubMed/NCBI

17 

Luong KV and Nguyen LT: The role of vitamin D in autoimmune hepatitis. J Clin Med Res. 5:407–415. 2013.PubMed/NCBI View Article : Google Scholar

18 

Zúñiga S, Firrincieli D, Housset C and Chignard N: Vitamin D and the vitamin D receptor in liver pathophysiology. Clin Res Hepatol Gastroenterol. 35:295–302. 2011.PubMed/NCBI View Article : Google Scholar

19 

Ramagopalan SV, Goldacre R, Disanto G, Giovannoni G and Goldacre MJ: Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: Record-linkage studies. BMC Med. 11:171–178. 2013.PubMed/NCBI View Article : Google Scholar

20 

Smyk DS, Orfanidou T, Invernizzi P, Bogdanos DP and Lenzi M: Vitamin D in autoimmune liver disease. Clin Res Hepatol Gastroenterol. 37:535–545. 2013.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Tao S, Zhang H, Zhao Q, Bu H, Wang H and Guo H: Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis. Exp Ther Med 19: 3419-3424, 2020.
APA
Tao, S., Zhang, H., Zhao, Q., Bu, H., Wang, H., & Guo, H. (2020). Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis. Experimental and Therapeutic Medicine, 19, 3419-3424. https://doi.org/10.3892/etm.2020.8601
MLA
Tao, S., Zhang, H., Zhao, Q., Bu, H., Wang, H., Guo, H."Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis". Experimental and Therapeutic Medicine 19.5 (2020): 3419-3424.
Chicago
Tao, S., Zhang, H., Zhao, Q., Bu, H., Wang, H., Guo, H."Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3419-3424. https://doi.org/10.3892/etm.2020.8601
Copy and paste a formatted citation
x
Spandidos Publications style
Tao S, Zhang H, Zhao Q, Bu H, Wang H and Guo H: Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis. Exp Ther Med 19: 3419-3424, 2020.
APA
Tao, S., Zhang, H., Zhao, Q., Bu, H., Wang, H., & Guo, H. (2020). Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis. Experimental and Therapeutic Medicine, 19, 3419-3424. https://doi.org/10.3892/etm.2020.8601
MLA
Tao, S., Zhang, H., Zhao, Q., Bu, H., Wang, H., Guo, H."Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis". Experimental and Therapeutic Medicine 19.5 (2020): 3419-3424.
Chicago
Tao, S., Zhang, H., Zhao, Q., Bu, H., Wang, H., Guo, H."Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3419-3424. https://doi.org/10.3892/etm.2020.8601
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