Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2020 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2020 Volume 19 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer

  • Authors:
    • Xiaohua Li
    • Min Xu
    • Wenyu Lv
    • Xingwang Yang
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasonography, Zibo City Linzi District People's Hospital, Zibo, Shandong 255400, P.R. China, Department of Pediatric Surgery, Burns and Plastic Surgery, and Hemorrhoids Fistula Surgery, Yidu Central Hospital of Weifang, Shandong 262500, P.R. China, Department of Oncology, Boxing People's Hospital, Binzhou, Shandong 256500, P.R. China, Department of General Surgery, Zibo City Linzi District People's Hospital, Zibo, Shandong 255400, P.R. China
  • Pages: 3391-3397
    |
    Published online on: March 12, 2020
       https://doi.org/10.3892/etm.2020.8602
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNAs (miRNAs/miRs) have important roles in tumor progression in various human cancers. Ultrasound‑targeted microbubble destruction (UTMD)‑mediated gene transfection has been considered a useful tool for improving cancer treatment. The present study aimed to investigate the role of miR‑767 in non‑small cell lung cancer (NSCLC) and further analyze the effects of UTMD‑mediated miR‑767 inhibition on tumor progression. The expression of miR‑767 was measured by reverse transcription‑quantitative PCR. UTMD‑mediated miR‑767 inhibition was achieved by the co‑transfection of microbubbles and miR‑767 inhibitor in NSCLC cells. Cell proliferation was assessed by a CCK‑8 assay and cell migration and invasion were examined by a Transwell assay. The expression of miR‑767 was increased in NSCLC serum, tissues and cells compared with controls. The reduction of miR‑767 in NSCLC cells led to the inhibition of cell proliferation, migration and invasion. UTMD increased the transfection efficiency of the miR‑767 inhibitor in NSCLC cells, and UTMD‑mediated miR‑767 inhibition resulted in a more significant suppressive effect on tumor cell proliferation, migration and invasion. Taken together, the results indicated that miR‑767 expression is upregulated in both NSCLC clinical samples and cells. The downregulation of miR‑767 can inhibit tumor cell proliferation, migration and invasion, and these effects are further promoted by UTMD‑mediated miR‑767 inhibition, which indicated the potential of a UTMD‑mediated miR‑767 inhibition as a novel therapeutic strategy for NSCLC treatment.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Torre LA, Siegel RL and Jemal A: Lung cancer statistics. Adv Exp Med Biol. 893:1–19. 2016.PubMed/NCBI View Article : Google Scholar

2 

Blandin Knight S, Crosbie PA, Balata H, Chudziak J, Hussell T and Dive C: Progress and prospects of early detection in lung cancer. Open Biol. 7(pii: 170070)2017.PubMed/NCBI View Article : Google Scholar

3 

Li O, Askin F, Gabrielson E and Li QK: Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Semin Cancer Biol. 52:103–109. 2018.PubMed/NCBI View Article : Google Scholar

4 

Dejima H, Iinuma H, Kanaoka R, Matsutani N and Kawamura M: Exosomal microRNA in plasma as a non-invasive biomarker for the recurrence of non-small cell lung cancer. Oncol Lett. 13:1256–1263. 2017.PubMed/NCBI View Article : Google Scholar

5 

Verdecchia A, Francisci S, Brenner H, Gatta G, Micheli A, Mangone L and Kunkler I: EUROCARE-4 Working Group: Recent cancer survival in Europe: A 2000-02 period analysis of EUROCARE-4 data. Lancet Oncol. 8:784–796. 2007.PubMed/NCBI View Article : Google Scholar

6 

Li Y, Zhang X, Yang Z, Li Y, Han B and Chen LA: miR-339-5p inhibits metastasis of non-small cell lung cancer by regulating the epithelial-to-mesenchymal transition. Oncol Lett. 15:2508–2514. 2018.PubMed/NCBI View Article : Google Scholar

7 

Xu J, Pan X and Hu Z: MiR-502 mediates esophageal cancer cell TE1 proliferation by promoting AKT phosphorylation. Biochem Biophys Res Commun. 501:119–123. 2018.PubMed/NCBI View Article : Google Scholar

8 

Li J, Liang Y, Lv H, Meng H, Xiong G, Guan X, Chen X, Bai Y and Wang K: miR-26a and miR-26b inhibit esophageal squamous cancer cell proliferation through suppression of c-MYC pathway. Gene. 625:1–9. 2017.PubMed/NCBI View Article : Google Scholar

9 

Qiu Z, Li H, Wang J and Sun C: miR-146a and miR-146b in the diagnosis and prognosis of papillary thyroid carcinoma. Oncol Rep. 38:2735–2740. 2017.PubMed/NCBI View Article : Google Scholar

10 

Song Y, Guo Q, Gao S and Hua K: miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3. Biochem Biophys Res Commun. 516:872–879. 2019.PubMed/NCBI View Article : Google Scholar

11 

Jiang K, Zhao T, Shen M, Zhang F, Duan S, Lei Z and Chen Y: MiR-940 inhibits TGF-β-induced epithelial-mesenchymal transition and cell invasion by targeting Snail in non-small cell lung cancer. J Cancer. 10:2735–2744. 2019.PubMed/NCBI View Article : Google Scholar

12 

Ji Y, Han Z, Shao L and Zhao Y: Ultrasound-targeted microbubble destruction of calcium channel subunit alpha 1D siRNA inhibits breast cancer via G protein-coupled receptor 30. Oncol Rep. 36:1886–1892. 2016.PubMed/NCBI View Article : Google Scholar

13 

Chen H and Hwang JH: Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors. J Ther Ultrasound. 1(10)2013.PubMed/NCBI View Article : Google Scholar

14 

Tinkov S, Bekeredjian R, Winter G and Coester C: Microbubbles as ultrasound triggered drug carriers. J Pharm Sci. 98:1935–1961. 2009.PubMed/NCBI View Article : Google Scholar

15 

Tu J, Zhang H, Yu J, Liufu C and Chen Z: Ultrasound-mediated microbubble destruction: A new method in cancer immunotherapy. Onco Targets Ther. 11:5763–5775. 2018.PubMed/NCBI View Article : Google Scholar

16 

Wu J and Li RK: Ultrasound-targeted microbubble destruction in gene therapy: A new tool to cure human diseases. Genes Dis. 4:64–74. 2017.PubMed/NCBI View Article : Google Scholar

17 

Loriot A, Van Tongelen A, Blanco J, Klaessens S, Cannuyer J, van Baren N, Decottignies A and De Smet C: A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. Epigenetics. 9:1163–1171. 2014.PubMed/NCBI View Article : Google Scholar

18 

Thienpont B, Galle E and Lambrechts D: TET enzymes as oxygen-dependent tumor suppressors: Exciting new avenues for cancer management. Epigenomics. 8:1445–1448. 2016.PubMed/NCBI View Article : Google Scholar

19 

Zhang K and Guo L: MiR-767 promoted cell proliferation in human melanoma by suppressing CYLD expression. Gene. 641:272–278. 2018.PubMed/NCBI View Article : Google Scholar

20 

Zhang J, Xu S, Xu J, Li Y, Zhang J, Zhang J and Lu X: miR7675p inhibits glioma proliferation and metastasis by targeting SUZ12. Oncol Rep. 42:55–66. 2019.PubMed/NCBI View Article : Google Scholar

21 

Leong-Poi H, Kuliszewski MA, Lekas M, Sibbald M, Teichert-Kuliszewska K, Klibanov AL, Stewart DJ and Lindner JR: Therapeutic arteriogenesis by ultrasound-mediated VEGF165 plasmid gene delivery to chronically ischemic skeletal muscle. Circ Res. 101:295–303. 2007.PubMed/NCBI View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

23 

Yang L, Dou Y, Sui Z, Cheng H, Liu X, Wang Q, Gao P, Qu Y and Xu M: Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression. Exp Ther Med. 19:603–610. 2020.PubMed/NCBI View Article : Google Scholar

24 

Huang L, Tang X, Shi X and Su L: miR-532-5p promotes breast cancer proliferation and migration by targeting RERG. Exp Ther Med. 19:400–408. 2020.PubMed/NCBI View Article : Google Scholar

25 

Zhang J, Kong X, Shi Q and Zhao B: MicroRNA-383-5p acts as a potential prognostic biomarker and an inhibitor of tumor cell proliferation, migration, and invasion in breast cancer. Cancer Biomark: Dec. 24:2019.doi: 10.3233/CBM-190704 (Epub ahead of print). PubMed/NCBI View Article : Google Scholar

26 

Biswas S: MicroRNAs as therapeutic agents: The future of the battle against cancer. Curr Top Med Chem. 18:2544–2554. 2018.PubMed/NCBI View Article : Google Scholar

27 

Azarbarzin S, Hosseinpour Feizi MA, Safaralizadeh R, Ravanbakhsh R, Kazemzadeh M, Fateh A, Karimi N and Moaddab Y: The value of miR-299-5p in diagnosis and prognosis of Intestinal-type gastric adenocarcinoma. Biochem Genet. 54:413–420. 2016.PubMed/NCBI View Article : Google Scholar

28 

Zheng W, Zhao J, Tao Y, Guo M, Ya Z, Chen C, Qin N, Zheng J, Luo J and Xu L: MicroRNA-21: A promising biomarker for the prognosis and diagnosis of non-small cell lung cancer. Oncol Lett. 16:2777–2782. 2018.PubMed/NCBI View Article : Google Scholar

29 

Bagheri A, Khorram Khorshid HR, Mowla SJ, Mohebbi HA, Mohammadian A, Yaseri M, Solaymani-Dodaran M, Sherafatian M and Tavallaie M: Altered miR-223 expression in sputum for diagnosis of Non-small cell lung cancer. Avicenna J Med Biotechnol. 9:189–195. 2017.PubMed/NCBI

30 

Sromek M, Glogowski M, Chechlinska M, Kulinczak M, Szafron L, Zakrzewska K, Owczarek J, Wisniewski P, Wlodarczyk R, Talarek L, et al: Changes in plasma miR-9, miR-16, miR-205 and miR-486 levels after non-small cell lung cancer resection. Cell Oncol (Dordr). 40:529–536. 2017.PubMed/NCBI View Article : Google Scholar

31 

Wang SY, Li Y, Jiang YS and Li RZ: Investigation of serum miR-411 as a diagnosis and prognosis biomarker for non-small cell lung cancer. Eur Rev Med Pharmacol Sci. 21:4092–4097. 2017.PubMed/NCBI

32 

Ow SH, Chua PJ and Bay BH: miR-149 as a potential molecular target for cancer. Curr Med Chem. 25:1046–1054. 2018.PubMed/NCBI View Article : Google Scholar

33 

Kang X, Kong F, Wu S, Liu Q, Yang C, Wu X and Zhang W: microRNA-612 suppresses the malignant development of non-small-cell lung cancer by directly targeting bromodomain-containing protein 4. Onco Targets Ther. 12:4167–4179. 2019.PubMed/NCBI View Article : Google Scholar

34 

Ling C, Wang X, Zhu J, Tang H, Du W, Zeng Y, Sun L, Huang JA and Liu Z: MicroRNA-4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non-small cell lung cancer. Cancer Me. 8:3520–3531. 2019.PubMed/NCBI View Article : Google Scholar

35 

Feng Y, Zhang L, Wu J, Khadka B, Fang Z, Gu J, Tang B, Xiao R, Pan G and Liu J: CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p/MAPK4 pathway. J Exp Clin Cancer Res. 38(54)2019.PubMed/NCBI View Article : Google Scholar

36 

Wang TY, Choe JW, Pu K, Devulapally R, Bachawal S, Machtaler S, Chowdhury SM, Luong R, Tian L, Khuri-Yakub B, et al: Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer. J Control Release. 203:99–108. 2015.PubMed/NCBI View Article : Google Scholar

37 

Lin L, Fan Y, Gao F, Jin L, Li D, Sun W, Li F, Qin P, Shi Q, Shi X and Du L: UTMD-promoted Co-delivery of gemcitabine and miR-21 inhibitor by Dendrimer-entrapped gold nanoparticles for pancreatic cancer therapy. Theranostics. 8:1923–1939. 2018.PubMed/NCBI View Article : Google Scholar

38 

Ji Y, Han Z, Shao L and Zhao Y: Evaluation of in vivo antitumor effects of low-frequency ultrasound-mediated miRNA-133a microbubble delivery in breast cancer. Cancer Med. 5:2534–2543. 2016.PubMed/NCBI View Article : Google Scholar

39 

Qin D, Li H and Xie H: Ultrasoundtargeted microbubble destructionmediated miR205 enhances cisplatin cytotoxicity in prostate cancer cells. Mol Med Rep. 18:3242–3250. 2018.PubMed/NCBI View Article : Google Scholar

40 

Park SJ, Lee BR, Kim HS, Ji YR, Sung YH, ShikChoi K, Park HD, Kim SH, Kim MO and Ryoo ZY: Inhibition of migration and invasion by Tet-1 overexpression in human lung carcinoma H460 cells. Oncol Res. 23:89–98. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li X, Xu M, Lv W and Yang X: Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer. Exp Ther Med 19: 3391-3397, 2020.
APA
Li, X., Xu, M., Lv, W., & Yang, X. (2020). Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer. Experimental and Therapeutic Medicine, 19, 3391-3397. https://doi.org/10.3892/etm.2020.8602
MLA
Li, X., Xu, M., Lv, W., Yang, X."Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer". Experimental and Therapeutic Medicine 19.5 (2020): 3391-3397.
Chicago
Li, X., Xu, M., Lv, W., Yang, X."Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3391-3397. https://doi.org/10.3892/etm.2020.8602
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Xu M, Lv W and Yang X: Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer. Exp Ther Med 19: 3391-3397, 2020.
APA
Li, X., Xu, M., Lv, W., & Yang, X. (2020). Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer. Experimental and Therapeutic Medicine, 19, 3391-3397. https://doi.org/10.3892/etm.2020.8602
MLA
Li, X., Xu, M., Lv, W., Yang, X."Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer". Experimental and Therapeutic Medicine 19.5 (2020): 3391-3397.
Chicago
Li, X., Xu, M., Lv, W., Yang, X."Ultrasound‑targeted microbubble destruction‑mediated miR‑767 inhibition suppresses tumor progression of non‑small cell lung cancer". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3391-3397. https://doi.org/10.3892/etm.2020.8602
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team