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Case Report Open Access

Main tract stenosis complicated by granulomatous with polyangiitis: A case report

  • Authors:
    • Daibing Zhou
    • Peng Zhang
    • Yuanyuan Zhang
    • Youzhi Zhang
    • Xiujuan Zhang
    • Jing Li
    • Zhongwen Zhou
    • Ning Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Huashan Hospital, Fudan University, Jing'an, Shanghai 200040, P.R. China, Department of Pathology, Huashan Hospital, Fudan University, Jing'an, Shanghai 200040, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3332-3336
    |
    Published online on: March 16, 2020
       https://doi.org/10.3892/etm.2020.8603
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Abstract

Granulomatosis with polyangiitis (GPA) is a rheumatic auto-immune disease involved in vasculitis. It is rarely reported that anti‑neutrophil cytoplasmic antibodies (ANCAs) associated with GPA would cause main tract stenosis. The current report documents a 54‑year‑old woman, with a history of severe cough, presented with wheezing and shortness of breath. Although she was treated with cephalosporin antibiotics for half a month, the symptoms were not alleviated. Accordingly, laboratory testing, radiology and pathology was performed at the Department of Respiratory and Critical Care Medicine, Huashan Hospital. Blood samples were tested negative for ANCAs. Chest CT revealed stenosis of the main trachea and uneven thickening of the tracheal wall. Nasal sinuses CT scanning indicated thickening of the nasal mucosa. Pathological analysis demonstrated chronic granulomatous inflammation with focal lesions. According to the classification criteria of ACR/EULAR provisional 2017, the patient was diagnosed with the ANCAs‑negative GPA. Following treatment with oral prednisone only for 6 months, obstruction of main tract was significantly improved. This case study is of interest for the promotion a potentially novel therapeutic intervention for GPA associated with the absence ANCA of in clinic.
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1 

Lynch JP III, Derhovanessian A, Tazelaar H and Belperio JA: Granulomatosis with polyangiitis (wegener's granulomatosis): Evolving concepts in treatment. Semin Respir Crit Care Med. 39:434–458. 2018.PubMed/NCBI View Article : Google Scholar

2 

Lane SE, Watts R and Scott DG: Epidemiology of systemic vasculitis. Curr Rheumatol Rep. 7:270–275. 2005.PubMed/NCBI View Article : Google Scholar

3 

Seo P and Stone JH: The antineutrophil cytoplasmic antibody-associated vasculitides. Am J Med. 117:39–50. 2004.PubMed/NCBI View Article : Google Scholar

4 

Iijima Y, Kobayashi Y, Uchida Y, Tsutsui T, Kakizaki Y, Naganuma T, Tsukamoto K, Oyama T and Miyashita Y: A case report of granulomatous polyangiitis complicated by tuberculous lymphadenitis. Medicine (Baltimore). 97(e12430)2018.PubMed/NCBI View Article : Google Scholar

5 

Emamikhah M, Sina F, Mokhtari M, Shirani F and Asadipanah M: Wegener's granulomatosis presenting as wallenberg syndrome: A case report. J Stroke Cerebrovas Dis. 28(e107-e109)2019.PubMed/NCBI View Article : Google Scholar

6 

Cartin-Ceba R, Peikert T and Specks U: Pathogenesis of ANCA-associated vasculitis. Curr Rheumatol Rep. 14:481–493. 2012.PubMed/NCBI View Article : Google Scholar

7 

Lutalo PM and D'Cruz DP: Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener's granulomatosis). J Autoimmun. 48-49:94–98. 2014.PubMed/NCBI View Article : Google Scholar

8 

Rao JK, Allen NB, Feussner JR and Weinberger M: A prospective study of antineutrophil cytoplasmic antibody (c-ANCA) and clinical criteria in diagnosing Wegener's granulomatosis. Lancet. 346:926–931. 1995.PubMed/NCBI View Article : Google Scholar

9 

Bonaci-Nikolic B, Andrejevic S, Bukilica M and Nikolic MM: Clinical and prognostic value of antineutrophil cytoplasmic antibodies in Wegener's granulomatosis and microscopic polyangiitis: Comment on the article by Russell et al. Arthritis Rheum. 46:278–280. 2002.PubMed/NCBI View Article : Google Scholar

10 

Sharma A, MB A, Naidu S, Rathi M, Pinto B, Dhir V, Verma R, Sharma K, Nada R, Jain S, et al: Validation of the ACR EULAR provisional 2017 classification criteria of granulomatosis with polyangiitis (GPA) amongst patients with ANCA associated vasculitis [abstract]. Arthritis Rheumato. 69 (Suppl):2017.PubMed/NCBI View Article : Google Scholar

11 

Merkel PA, Xie G, Monach PA, Ji X, Ciavatta DJ, Byun J, Pinder BD, Zhao A, Zhang J, Tadesse Y, et al: Identification of functional and expression polymorphisms associated with risk for antineutrophil cytoplasmic autoantibody-associated vasculitis. Arthritis Rheum. 69:1054–1066. 2017.PubMed/NCBI View Article : Google Scholar

12 

Gao Y and Zhao MH: Review article: Drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Nephrol (Carlton). 14:33–41. 2009.PubMed/NCBI View Article : Google Scholar

13 

Mahr AD, Neogi T, Lavalley MP, Davis JC, Hoffman GS, McCune WJ, Specks U, Spiera RF, St Clair EW, Stone JH, et al: Assessment of the item selection and weighting in the Birmingham vasculitis activity score for Wegener's granulomatosis. Arthritis Rheum. 59:884–891. 2008.PubMed/NCBI View Article : Google Scholar

14 

Mukhtyar C, Guillevin L, Cid MC, Dasgupta B, de Groot K, Gross W, Hauser T, Hellmich B, Jayne D, Kallenberg CG, et al: EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis. 68:310–317. 2009.PubMed/NCBI View Article : Google Scholar

15 

Polychronopoulos VS, Prakash UB, Golbin JM, Edell ES and Specks U: Airway involvement in Wegener's granulomatosis. Rheum Dis Clin North Am. 33:755–775. 2007.PubMed/NCBI View Article : Google Scholar

16 

Almouhawis HA, Leao JC, Fedele S and Porter SR: Wegener's granulomatosis: A review of clinical features and an update in diagnosis and treatment. J Oral Pathol Med. 42:507–516. 2013.PubMed/NCBI View Article : Google Scholar

17 

Cadoni G, Prelajade D, Campobasso E, Calŏ L, Agostino S, Manna R and Paludetti G: Wegener's granulomatosis: A challenging disease for otorhinolaryngologists. Acta Otolaryngol. 125:1105–1110. 2005.PubMed/NCBI View Article : Google Scholar

18 

Semple D, Keogh J, Forni L and Venn R: Clinical review: Vasculitis on the intensive care unit-part 2: Treatment and prognosis. Crit Care. 9:193–197. 2005.PubMed/NCBI View Article : Google Scholar

19 

Heijl C, Westman K, Höglund P and Mohammad AJ: Malignancies in patients with ANCA-associated vasculitis-A population based cohort study. J Rheumatol. pii(jrheum.181438)2019.PubMed/NCBI View Article : Google Scholar

20 

Nagasaka K, Harigai M, Hagino N, Hara A, Horita T, Hayashi T, Itabashi M, Ito S, Katsumata Y, Kawashima S, et al: Systematic review and meta-analysis for 2017 clinical practice guidelines of the Japan research committee of the ministry of health, labour, and welfare for intractable vasculitis for the management of ANCA-associated vasculitis. Mod Rheumatol. 29:119–129. 2019.PubMed/NCBI View Article : Google Scholar

21 

Peters JE, Salama AD and Ind PW: Wegener's granulomatosis presenting as acute systemic vasculitis following 20 years of limited tracheobronchial disease. J Laryngol Otol. 123:1375–1377. 2009.PubMed/NCBI View Article : Google Scholar

22 

Heijl C, Mohammad AJ, Westman K and Hoglund P: Long-term patient survival in a Swedish population-based cohort of patients with ANCA-associated vasculitis. RMD Open. 3(e000435)2017.PubMed/NCBI View Article : Google Scholar

23 

von Borstel A, Land J, Abdulahad WH, Rutgers A, Stegeman CA, Diepstra A, Heeringa P and Sanders JS: CD27(+)CD38(hi) B cell frequency during remission predicts relapsing disease in granulomatosis with polyangiitis patients. Front Immunol. 10(2221)2019.PubMed/NCBI View Article : Google Scholar

24 

Cosano Povedano A, Munoz Cabrera L, Cosano Povedano FJ, Rubio Sanchez J, Pascual Martinez N and Escribano Duenas A: Endoscopic treatment of central airway stenosis: Five years' experience. Arch Bronconeumol(Spanish). 41:322–327. 2005.PubMed/NCBI View Article : Google Scholar

25 

McClure M, Gopaluni S, Jayne D and Jones R: B cell therapy in ANCA-associated vasculitis: Current and emerging treatment options. Nat Rev Rheumatol. 14:580–591. 2018.PubMed/NCBI View Article : Google Scholar

26 

Bekker P, Dairaghi D, Seitz L, Leleti M, Wang Y, Ertl L, Baumgart T, Shugarts S, Lohr L, Dang T, et al: Correction: Characterization of pharmacologic and pharmacokinetic properties of CCX168, a potent and selective orally administered complement 5a receptor inhibitor, based on preclinical evaluation and randomized phase 1 clinical study. PLoS One. 14(e0210593)2019.PubMed/NCBI View Article : Google Scholar

27 

Berti A, Cavalli G, Campochiaro C, Guglielmi B, Baldissera E, Cappio S, Sabbadini MG, Doglioni C and Dagna L: Interleukin-6 in ANCA-associated vasculitis: Rationale for successful treatment with tocilizumab. Semin Arthritis Rheum. 45:48–54. 2015.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhou D, Zhang P, Zhang Y, Zhang Y, Zhang X, Li J, Zhou Z and Zhu N: Main tract stenosis complicated by granulomatous with polyangiitis: A case report. Exp Ther Med 19: 3332-3336, 2020.
APA
Zhou, D., Zhang, P., Zhang, Y., Zhang, Y., Zhang, X., Li, J. ... Zhu, N. (2020). Main tract stenosis complicated by granulomatous with polyangiitis: A case report. Experimental and Therapeutic Medicine, 19, 3332-3336. https://doi.org/10.3892/etm.2020.8603
MLA
Zhou, D., Zhang, P., Zhang, Y., Zhang, Y., Zhang, X., Li, J., Zhou, Z., Zhu, N."Main tract stenosis complicated by granulomatous with polyangiitis: A case report". Experimental and Therapeutic Medicine 19.5 (2020): 3332-3336.
Chicago
Zhou, D., Zhang, P., Zhang, Y., Zhang, Y., Zhang, X., Li, J., Zhou, Z., Zhu, N."Main tract stenosis complicated by granulomatous with polyangiitis: A case report". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3332-3336. https://doi.org/10.3892/etm.2020.8603
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou D, Zhang P, Zhang Y, Zhang Y, Zhang X, Li J, Zhou Z and Zhu N: Main tract stenosis complicated by granulomatous with polyangiitis: A case report. Exp Ther Med 19: 3332-3336, 2020.
APA
Zhou, D., Zhang, P., Zhang, Y., Zhang, Y., Zhang, X., Li, J. ... Zhu, N. (2020). Main tract stenosis complicated by granulomatous with polyangiitis: A case report. Experimental and Therapeutic Medicine, 19, 3332-3336. https://doi.org/10.3892/etm.2020.8603
MLA
Zhou, D., Zhang, P., Zhang, Y., Zhang, Y., Zhang, X., Li, J., Zhou, Z., Zhu, N."Main tract stenosis complicated by granulomatous with polyangiitis: A case report". Experimental and Therapeutic Medicine 19.5 (2020): 3332-3336.
Chicago
Zhou, D., Zhang, P., Zhang, Y., Zhang, Y., Zhang, X., Li, J., Zhou, Z., Zhu, N."Main tract stenosis complicated by granulomatous with polyangiitis: A case report". Experimental and Therapeutic Medicine 19, no. 5 (2020): 3332-3336. https://doi.org/10.3892/etm.2020.8603
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