Increased levels of miR‑372 correlate with disease progression in patients with hyperlipidemic acute pancreatitis

Shan,Yuqiang; Kong,Wencheng; Zhu,Akao; Zhang,Jian; Ying,Rongchao; Zhu,Weiming

doi:10.3892/etm.2020.8609

Increased levels of miR‑372 correlate with disease progression in patients with hyperlipidemic acute pancreatitis

Authors:
- Yuqiang Shan
- Wencheng Kong
- Akao Zhu
- Jian Zhang
- Rongchao Ying
- Weiming Zhu
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Affiliations: Department of General Surgery, Jinling Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China, Department of Gastroenterological Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China
Published online on: March 19, 2020 https://doi.org/10.3892/etm.2020.8609
Pages: 3845-3850

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Abstract

The aim of the present study was to investigate the expression of microRNA (miRNA)‑372 in the serum of patients with hyperlipidemic acute pancreatitis (HTGAP), and its clinical significance. Patients with a serum lipid concentration ≥11.3 or 5.65‑11.3 mmol/l with chylous serum were included in group A (n=40). The remaining patients did not have HTGAP and were included in group B (B). A further 25 patients with hyperlipidemia, but not AP (group C), and 30 healthy volunteers (group D) were recruited as controls. The level of miR‑372 in the serum of group A (4.76±2.60) was significantly increased compared with groups B (0.98±0.80), C (0.85±0.62) and D (0.76±0.44); however, there was no significant difference in the expression of miR‑372 between groups B, C and D. The expression level of miR‑372 was significantly increased in the severe HTGAP group (6.45±2.20) compared with the mild HTGAP group (3.08±1.74). Further experiments suggested that the expression level of miR‑372 was positively correlated with the level of triacylglycerol (r=0.666; P<0.001) but not with the level of amylase (r=‑0.145; P>0.05). ROC analysis indicated that the combined use of miR‑372 expression levels and Acute Physiology and Chronic Health Evaluation II scoring improved the diagnostic value for HTGAP. In summary, the expression of miR‑372 in HTGAP was significantly upregulated and increased with the severity of the disease. The results of the present study may provide a novel strategy for the diagnosis and severity assessment of HTGAP in the clinic.

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