Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
June-2020 Volume 19 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2020 Volume 19 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article

Protective effects of postconditioning in transvaginally created pneumoperitoneum

  • Authors:
    • Koba Shanava
    • Szaniszlo Javor
    • Vakhtang Kerkadze
    • Ivane Abiatari
    • György Weber
  • View Affiliations / Copyright

    Affiliations: Institute of Medical Research, Ilia State University, Tbilisi 0162, Georgia, Department of Surgical Research and Techniques, Medical Faculty, University of Pecs, H‑7624 Pécs, Hungary
  • Pages: 3861-3866
    |
    Published online on: March 19, 2020
       https://doi.org/10.3892/etm.2020.8616
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

There are reports of ischemic complications in clinical practice after laparoscopy using pneumoperitoneum. Conditioning has a beneficial effect for various ischemic diseases. This experimental study was designed to evaluate the effects of postconditioning in transvaginally created pneumoperitoneum. Sixty adult female rats, weighing 300±50 g were divided into four equal groups. Pneumoperitoneum was created by CO2 insufflation under a pressure of 10 mmHg. Rats in the first group (sham) were subjected to only sham‑operation or gas insufflation. The second group (TV/PP) was subjected to pneumoperitoneum for 60 min followed by 30 min of desufflation. The third group (post‑5) was subjected to pneumoperitoneum for 60 min followed by 5 min of desufflation, 5 min of insufflation and again followed by 30 min of desufflation. The fourth group (post‑2.5) was subjected to pneumoperitoneum for 60 min followed by 2.5 min of desufflation and 2.5 min of insufflation‑repeated in two cycles‑ and then followed by 30 min of desufflation. The rats were sacrificed, and blood was collected after 30 min, 2 and 6 h from the last desufflation. Levels of oxidative stress markers, malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), sulfhydryl groups (SH) and inflammatory cytokine TNF‑α, were analyzed. Levels of MDA in the post‑5 group were significantly reduced compared to the TV/PP and post‑2.5 groups. The level of GSH in TV/PP animals was markedly reduced compared to the Sham, Post‑5 and Post‑2.5 groups. In addition, levels of SH were increased in the Post‑5 group in comparison to the Sham, TV/PP and Post‑2.5 groups. No difference in the activity of SOD between the groups was found, and the concentration of TNF‑α in TV/PP animals was significantly higher than that in the Sham and postconditioning groups. Overall, the results of the present study indicate that postconditioning can reduce pneumoperitoneum‑induced oxidative injury.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Clarke HC: History of endoscopic and laparoscopic surgery. World J Surg. 25:967–968. 2001.PubMed/NCBI View Article : Google Scholar

2 

Sammour T, Mittal A, Loveday BP, Kahokehr A, Phillips AR, Windsor JA and Hill AG: Systematic review of oxidative stress associated with pneumoperitoneum. Br J Surg. 96:836–850. 2009.PubMed/NCBI View Article : Google Scholar

3 

Liu KX, Li YS, Huang WQ, Chen SQ, Wang ZX, Liu JX and Xia Z: Immediate postconditioning during reperfusion attenuates intestinal injury. Intensive Care Med. 35:933–942. 2009.PubMed/NCBI View Article : Google Scholar

4 

Polat C, Yilmaz S, Serteser M, Koken T, Kahraman A and Dilek ON: The effect of different intraabdominal pressures on lipid peroxidation and protein oxidation status during laparoscopic cholecystectomy. Surg Endosc. 17:1719–1722. 2003.PubMed/NCBI View Article : Google Scholar

5 

Ates E, Yilmaz S, Ihtiyar E, Yasar B and Karahuseyinoglu E: Preconditioning-like amelioration of erythropoietin against laparoscopy-induced oxidative injury. Surg Endosc. 20:815–819. 2006.PubMed/NCBI View Article : Google Scholar

6 

Hatipoglu S, Akbulut S, Hatipoglu F and Abdullayev R: Effect of laparoscopic abdominal surgery on splanchnic circulation: Historical developments. World J Gastroenterol. 20:18165–18176. 2014.PubMed/NCBI View Article : Google Scholar

7 

Veres TG, Petrovics L, Sárvári K, Vereczkei A, Jancsó G, Farkas KB and Takács I: The effect of laparoscopic pre- and postconditioning on pneumoperitoneum induced injury of peritoneum. Clin Hemorheol Microcirc, May 27, 2019 (Epub ahead of print).

8 

Loubele ST, ten Cate H and Spronk HM: Anticoagulant therapy in critical organ ischaemia/reperfusion injury. Thromb Haemost. 104:136–142. 2010.PubMed/NCBI View Article : Google Scholar

9 

Lipton P: Ischemic cell death in brain neurons. Physiol Rev. 79:1431–1568. 1999.PubMed/NCBI View Article : Google Scholar

10 

Oksuz H, Bulbuloglu E, Senoglu N, Ciralik H, Yuzbasioglu MF, Kilinc M, Dogan Z, Goksu M, Yildiz H, Ozkan OV and Atli Y: Re-protective effects of pre- and post-laparoscopy conditioning, zinc, pentoxifylline, and N-acetylcysteine in an animal model of laparoscopy-induced ischemia/reperfusion injury of the kidney. Ren Fail. 31:297–302. 2009.PubMed/NCBI View Article : Google Scholar

11 

Yilmaz S, Ates E, Polat C, Koken T, Tokyol C, Akbulut G and Gokce O: Ischemic preconditioning decreases laparoscopy-induced oxidative stress in small intestine. Hepatogastroenterology. 50:979–982. 2003.PubMed/NCBI

12 

Yilmaz S, Koken T, Tokyol C, Kahraman A, Akbulut G, Serteser M, Polat C, Gokce C and Gokce O: Can preconditioning reduce laparoscopy-induced tissue injury? Surg Endosc. 17:819–824. 2003.PubMed/NCBI View Article : Google Scholar

13 

Zhao ZQ, Corvera JS, Halkos ME, Kerendi F, Wang NP, Guyton RA and Vinten-Johansen J: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: Comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 285:H579–H588. 2003.PubMed/NCBI View Article : Google Scholar

14 

Jávor S, Shanava K, Hocsák E, Kürthy M, Lantos J, Borsiczky B, Takács I, Horváth S, Balatonyi B, Ferencz S, et al: Preconditioning is a method that may reduce the negative side-effect of pneumoperitoneum. Interv Med Appl Sci. 2:115–120. 2010.

15 

Placer ZA, Cushman LL and Johnson BC: Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systems. Anal Biochem. 16:359–364. 1966.PubMed/NCBI View Article : Google Scholar

16 

Sedlak J and Lindsay RH: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 25:192–205. 1968.PubMed/NCBI View Article : Google Scholar

17 

Misra HP and Fridovich I: The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 247:3170–3175. 1972.PubMed/NCBI

18 

Ott DE: The peritoneum and the pneumoperitoneum: A review to improve clinical outcome. Gynecol Surg. 1:101–106. 2004.

19 

Lee JY and Choi SH: Evaluation of total oxidant and antioxidant status in dogs under different CO2 pneumoperitoneum conditions. Acta Vet Scand. 57(23)2015.PubMed/NCBI View Article : Google Scholar

20 

Ypsilantis P, Lambropoulou M, Tentes I, Chryssidou M, Georgantas T and Simopoulos C: Room air versus carbon dioxide pneumoperitoneum: Effects on oxidative state, apoptosis and histology of splanchnic organs. Surg Endosc. 30:1388–1395. 2016.PubMed/NCBI View Article : Google Scholar

21 

Thuret R, Saint Yves T, Tillou X, Chatauret N, Thuillier R, Barrou B and Billault C: Ischemic pre- and post-conditioning: Current clinical applications. Prog Urol. 24 (Suppl 1):S56–S61. 2014.PubMed/NCBI View Article : Google Scholar

22 

Trunzo JA, McGee MF, Cavazzola LT, Schomisch S, Nikfarjam M, Bailey J, Mishra T, Poulose BK, Lee YJ, Ponsky JL and Marks JM: Peritoneal inflammatory response of natural orifice translumenal endoscopic surgery (NOTES) versus laparoscopy with carbon dioxide and air pneumoperitoneum. Surg Endosc. 24:1727–1736. 2010.PubMed/NCBI View Article : Google Scholar

23 

Bingener J, Krishnegowda NK and Michalek JE: Immunologic parameters during NOTES compared with laparoscopy in a randomized blinded porcine trial. Surg Endosc. 23:178–181. 2009.PubMed/NCBI View Article : Google Scholar

24 

Berguer R, Cornelius T and Dalton M: The optimum pneumoperitoneum pressure for laparoscopic surgery in the rat model. A detailed cardiorespiratory study. Surg Endosc. 11:915–918. 1997.PubMed/NCBI View Article : Google Scholar

25 

Al-Saeedi M, Nickkholgh A, Schultze D, Flechtenmacher C, Zorn M, Liang R, Gutt CN and Schemmer P: Glycine protects the liver from reperfusion injury following pneumoperitoneum. Eur Surg Res. 59:91–99. 2018.PubMed/NCBI View Article : Google Scholar

26 

Mateos R, Lecumberri E, Ramos S, Goya L and Bravo L: Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress. Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits. J Chromatogr B Analyt Technol Biomed Life Sci. 827:76–82. 2005.PubMed/NCBI View Article : Google Scholar

27 

Kolagal V, Karanam SA, Dharmavarapu PK, D'Souza R, Upadhya S, Kumar V, Kedage V, Muttigi MS, Shetty JK and Prakash M: Determination of oxidative stress markers and their importance in early diagnosis of uremia-related complications. Indian J Nephrol. 19:8–12. 2009.PubMed/NCBI View Article : Google Scholar

28 

Sack M: Tumor necrosis factor-alpha in cardiovascular biology and the potential role for anti-tumor necrosis factor-alpha therapy in heart disease. Pharmacol Ther. 94:123–135. 2002.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shanava K, Javor S, Kerkadze V, Abiatari I and Weber G: Protective effects of postconditioning in transvaginally created pneumoperitoneum. Exp Ther Med 19: 3861-3866, 2020.
APA
Shanava, K., Javor, S., Kerkadze, V., Abiatari, I., & Weber, G. (2020). Protective effects of postconditioning in transvaginally created pneumoperitoneum. Experimental and Therapeutic Medicine, 19, 3861-3866. https://doi.org/10.3892/etm.2020.8616
MLA
Shanava, K., Javor, S., Kerkadze, V., Abiatari, I., Weber, G."Protective effects of postconditioning in transvaginally created pneumoperitoneum". Experimental and Therapeutic Medicine 19.6 (2020): 3861-3866.
Chicago
Shanava, K., Javor, S., Kerkadze, V., Abiatari, I., Weber, G."Protective effects of postconditioning in transvaginally created pneumoperitoneum". Experimental and Therapeutic Medicine 19, no. 6 (2020): 3861-3866. https://doi.org/10.3892/etm.2020.8616
Copy and paste a formatted citation
x
Spandidos Publications style
Shanava K, Javor S, Kerkadze V, Abiatari I and Weber G: Protective effects of postconditioning in transvaginally created pneumoperitoneum. Exp Ther Med 19: 3861-3866, 2020.
APA
Shanava, K., Javor, S., Kerkadze, V., Abiatari, I., & Weber, G. (2020). Protective effects of postconditioning in transvaginally created pneumoperitoneum. Experimental and Therapeutic Medicine, 19, 3861-3866. https://doi.org/10.3892/etm.2020.8616
MLA
Shanava, K., Javor, S., Kerkadze, V., Abiatari, I., Weber, G."Protective effects of postconditioning in transvaginally created pneumoperitoneum". Experimental and Therapeutic Medicine 19.6 (2020): 3861-3866.
Chicago
Shanava, K., Javor, S., Kerkadze, V., Abiatari, I., Weber, G."Protective effects of postconditioning in transvaginally created pneumoperitoneum". Experimental and Therapeutic Medicine 19, no. 6 (2020): 3861-3866. https://doi.org/10.3892/etm.2020.8616
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team