Open Access

Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway

  • Authors:
    • Hongyun Cheng
    • Xue Jiang
    • Qian Zhang
    • Jun Ma
    • Ronghui Cheng
    • Hongmei Yong
    • Huichang Shi
    • Xueyi Zhou
    • Liyue Ge
    • Guangyi Gao
  • View Affiliations

  • Published online on: April 7, 2020     https://doi.org/10.3892/etm.2020.8649
  • Pages: 3798-3804
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In recent years, the incidence of colorectal cancer (CRC) has increased and research into new treatment methods for CRC has become a hot topic. Naringin has an inhibitory effect on the PI3k/AKT/mTOR signaling pathway in various tumor cell types and the effect of naringin is closely related to the occurrence and proliferation of tumor cells. The aim of this present study was to investigate whether naringin could inhibit the proliferation of CRC cells by inhibiting the PI3K/AKT/mTOR signaling pathway. This could provide a more mechanism‑based treatment for CRC. MTT assays were used to detect the proliferation of CRC cells treated with various concentrations of naringin. The degree of apoptosis and the expression of apoptosis‑related proteins (Bcl‑2 and Bax) in CRC cells stimulated by naringin was detected using flow cytometry and western blot assays, respectively. The expression levels of PI3K/AKT/mTOR‑related proteins [PI3K, AKT, mTOR, phosphorylated (p)‑PI3K, p‑AKT and p‑mTOR] after naringin stimulation in CRC cells were detected using western blot assays. Naringin inhibited the proliferation of CRC cells in a dose‑dependent manner. Naringin promoted the apoptosis of CRC cells and inhibited the activation of the PI3K/AKT/mTOR signaling pathway in a dose‑dependent manner. The results demonstrated that naringin may be a promising therapeutic agent for the treatment of CRC, which may inhibit the proliferation of CRC cells and induce apoptosis by inhibiting the PI3K/AKT/mTOR signaling pathway.
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June-2020
Volume 19 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Cheng H, Jiang X, Zhang Q, Ma J, Cheng R, Yong H, Shi H, Zhou X, Ge L, Gao G, Gao G, et al: Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway. Exp Ther Med 19: 3798-3804, 2020
APA
Cheng, H., Jiang, X., Zhang, Q., Ma, J., Cheng, R., Yong, H. ... Gao, G. (2020). Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway. Experimental and Therapeutic Medicine, 19, 3798-3804. https://doi.org/10.3892/etm.2020.8649
MLA
Cheng, H., Jiang, X., Zhang, Q., Ma, J., Cheng, R., Yong, H., Shi, H., Zhou, X., Ge, L., Gao, G."Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway". Experimental and Therapeutic Medicine 19.6 (2020): 3798-3804.
Chicago
Cheng, H., Jiang, X., Zhang, Q., Ma, J., Cheng, R., Yong, H., Shi, H., Zhou, X., Ge, L., Gao, G."Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway". Experimental and Therapeutic Medicine 19, no. 6 (2020): 3798-3804. https://doi.org/10.3892/etm.2020.8649