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Article

Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome

  • Authors:
    • Dana Carmen Zaha
    • Cosmin Vesa
    • Diana Uivarosan
    • Ovidiu Bratu
    • Ovidiu Fratila
    • Delia Mirela Tit
    • Carmen Pantis
    • Camelia C. Diaconu
    • Simona Bungau
  • View Affiliations / Copyright

    Affiliations: Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy of Oradea, University of Oradea, 410073 Oradea, Romania, Clinical Department 3, University of Medicine and Pharmacy ‘Carol Davila’, 050474 Bucharest, Romania, Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania , Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania, Clinical County Emergency Hospital of Oradea, 410169 Oradea, Romania, Clinical Department 5, University of Medicine and Pharmacy ‘Carol Davila’, 050474 Bucharest, Romania
  • Pages: 121-128
    |
    Published online on: April 15, 2020
       https://doi.org/10.3892/etm.2020.8663
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Abstract

Metabolic syndrome is associated with increased risk of cardiovascular disease. This study investigated the correlation between adipocyte and inflammation biomarkers, and metabolic syndrome and its components. The study included 80 patients with normal body-mass index and 80 obese patients. The groups were assessed for serum values of adiponectin, leptin and highly sensitive C reactive protein (hsCRP), the homeostatic model assessment of insulin resistance (HOMA-IR), as well as the influence of these biochemical markers on the prevalence of metabolic syndrome and its components. Leptin, HOMA-IR and hsCRP had statistically significant (P<0.01) higher values in the group of obese subjects, while adiponectin had statistically significant (P<0.01) lower values. The prevalence of metabolic syndrome was 35% in the obese group and 5% in the normal weight group. Adiponectin and HOMA-IR were the variables significantly associated with metabolic syndrome (P<0.01), adiponectin/HOMA-IR ratio and leptin/adiponectin ratio were also associated with metabolic syndrome (P<0.01). No relationship was found between metabolic syndrome and hsCRP. Adiponectin and adiponectin/HOMA-IR were associated with all the components of metabolic syndrome and they can be useful to identify patients with high risk of diabetes mellitus and cardiovascular disease.
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Copy and paste a formatted citation
Spandidos Publications style
Zaha DC, Vesa C, Uivarosan D, Bratu O, Fratila O, Tit DM, Pantis C, Diaconu CC and Bungau S: Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome. Exp Ther Med 20: 121-128, 2020.
APA
Zaha, D.C., Vesa, C., Uivarosan, D., Bratu, O., Fratila, O., Tit, D.M. ... Bungau, S. (2020). Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome. Experimental and Therapeutic Medicine, 20, 121-128. https://doi.org/10.3892/etm.2020.8663
MLA
Zaha, D. C., Vesa, C., Uivarosan, D., Bratu, O., Fratila, O., Tit, D. M., Pantis, C., Diaconu, C. C., Bungau, S."Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome". Experimental and Therapeutic Medicine 20.1 (2020): 121-128.
Chicago
Zaha, D. C., Vesa, C., Uivarosan, D., Bratu, O., Fratila, O., Tit, D. M., Pantis, C., Diaconu, C. C., Bungau, S."Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome". Experimental and Therapeutic Medicine 20, no. 1 (2020): 121-128. https://doi.org/10.3892/etm.2020.8663
Copy and paste a formatted citation
x
Spandidos Publications style
Zaha DC, Vesa C, Uivarosan D, Bratu O, Fratila O, Tit DM, Pantis C, Diaconu CC and Bungau S: Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome. Exp Ther Med 20: 121-128, 2020.
APA
Zaha, D.C., Vesa, C., Uivarosan, D., Bratu, O., Fratila, O., Tit, D.M. ... Bungau, S. (2020). Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome. Experimental and Therapeutic Medicine, 20, 121-128. https://doi.org/10.3892/etm.2020.8663
MLA
Zaha, D. C., Vesa, C., Uivarosan, D., Bratu, O., Fratila, O., Tit, D. M., Pantis, C., Diaconu, C. C., Bungau, S."Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome". Experimental and Therapeutic Medicine 20.1 (2020): 121-128.
Chicago
Zaha, D. C., Vesa, C., Uivarosan, D., Bratu, O., Fratila, O., Tit, D. M., Pantis, C., Diaconu, C. C., Bungau, S."Influence of inflammation and adipocyte biochemical markers on the components of metabolic syndrome". Experimental and Therapeutic Medicine 20, no. 1 (2020): 121-128. https://doi.org/10.3892/etm.2020.8663
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