Assessment of para‑inflammation in a wound healing model

  • Authors:
    • Guoping Wang
    • Guobo Shen
    • Xiaoshuang Jiang
    • Zhixing Chen
    • Tao Yin
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  • Published online on: April 15, 2020     https://doi.org/10.3892/etm.2020.8666
  • Pages: 655-661
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Abstract

A thorough understanding of the inflammatory process has substantial biological and clinical relevance. Para-inflammation has been described as an adaptive response of the immune system to low levels of tissue stress. However, the role of para‑inflammation in wound repair requires further investigation. In the present study, the expression levels of several para‑inflammation genes were assessed in a murine cutaneous wound healing model. The results revealed that the expression levels of the para‑inflammation genes were significantly altered. Among the genes that were examined, the expression levels of solute carrier family 7 member 11 (Slc7a11) paralleled those of the M2 macrophage‑associated genes. Further investigation indicated that the Slc7a11 gene and its encoded protein cystine/glutamate transporter exhibited increased expression levels in IL‑4‑induced M2 macrophages. Notably, the inhibition of para‑inflammation by sulindac prolonged wound healing process. The present study indicated that para‑inflammation exhibited a protective effect in wound healing and provided new insight for host tissue repair.
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July-2020
Volume 20 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang G, Shen G, Jiang X, Chen Z and Yin T: Assessment of para‑inflammation in a wound healing model. Exp Ther Med 20: 655-661, 2020
APA
Wang, G., Shen, G., Jiang, X., Chen, Z., & Yin, T. (2020). Assessment of para‑inflammation in a wound healing model. Experimental and Therapeutic Medicine, 20, 655-661. https://doi.org/10.3892/etm.2020.8666
MLA
Wang, G., Shen, G., Jiang, X., Chen, Z., Yin, T."Assessment of para‑inflammation in a wound healing model". Experimental and Therapeutic Medicine 20.1 (2020): 655-661.
Chicago
Wang, G., Shen, G., Jiang, X., Chen, Z., Yin, T."Assessment of para‑inflammation in a wound healing model". Experimental and Therapeutic Medicine 20, no. 1 (2020): 655-661. https://doi.org/10.3892/etm.2020.8666